Protein restriction and control of blood pressure delay the progression of renal disease in laboratory animals¹–³. Most studies in humans⁴–¹⁰ have suggested that a restriction of dietary protein is beneficial, especially in patients with advanced renal ...

The Holt-Oram syndrome (Mendelian Inheritance in Man number 142900),¹ also called the heart-hand syndrome, is an inherited disorder that causes anomalies of the upper limbs and heart. The syndrome is transmitted as an autosomal dominant trait that is ...

Surveillance studies to detect residual, recurrent, and metastatic cancer are a standard part of clinical trials and are considered good medical practice. Such studies enable physicians to assess the response of the tumor to treatment, determine the time ...

Herpes zoster is caused by a reactivation of the varicella-zoster virus, which remains latent in the sensory ganglia after primary infection¹. In immunocompetent patients, herpes zoster is predominantly a disease of the elderly. During the acute illness, ...

More than 80 percent of children have had chickenpox by 10 years of age, and more than 85 percent of adults who report that they have not had chickenpox are actually seropositive for antibodies to the varicella-zoster virus. Yet, because some seronegative ...

Figure 1. Herpes Zoster.

A 78-year-old man had numerous crusts and erosions on the right side of his face and scalp. Staining with a monoclonal-antibody stain (Syva Microtrak, Palo Alto, Calif.) conjugated with fluorescein isothiocyanate specific for ...

It has been 30 years since the surgeon general of the United States released the first report of the Advisory Committee on Smoking and Health. In each of the subsequent reports, cigarette smoking has been identified as the most important source of ...

Cardiomyopathy is an important cause of morbidity and mortality throughout the world in children and adults. In contrast to secondary causes of cardiomyopathy, such as hypertension and ischemic heart disease, the causes and pathogenesis of primary ...

Presentation of Case

A 62-year-old man was admitted to the hospital because of bilateral epistaxis and orthostatic hypotension. He had a long history of hypertension treated with lisinopril. Gout of five years' duration was suppressed by allopurinol. A ...

In rats, renal diseases progress to the end stage, but the rate of progression can be slowed dramatically by dietary protein restriction¹. In humans, most renal diseases also progress to death due to uremia, unless transplantation or dialysis is provided²...

Cardiovascular disease is the leading cause of death in developed countries. It is widely recognized that a person's genetic makeup, reflected by his or her family history, may influence the risk of various forms of cardiovascular disease. Although ...

Herpes zoster (shingles) is an acute infection of the dorsal-root ganglia and skin caused by a reactivation of varicella-zoster virus, the cause of chickenpox. It is characterized by pain and vesicles on an erythematous base limited to one to three ...

To the Editor: In their article (Oct. 28 issue)¹ on the participation of physicians in capital punishment, Truog and Brennan argue that “involvement in capital punishment is grounds for revoking a physician's license.” Adopting this view could lead to ...

To the Editor: Lewis et al. (Nov. 11 issue)¹ report that captopril was beneficial in patients with diabetic nephropathy. We have several questions.

Since base-line urinary protein excretion was significantly lower in the captopril group, is it possible ...

To the Editor: The screening criteria to identify young infants at low risk of serious bacterial infection as originally proposed by Dagan et al.¹,² and subsequently modified and used by others³,⁴ do not include a chest film or a lumbar puncture. The ...

To the Editor: The study of Burrows and Kelton (Nov. 11 issue)¹ focuses on moderate neonatal thrombocytopenia (platelet count, 20,000 to 50,000 per cubic millimeter) and severe neonatal thrombocytopenia (<20,000 per cubic millimeter) at the time of ...

To the Editor: In Case 45-1993 (Nov. 11 issue),¹ a 23-year-old man with asthma is eventually given a diagnosis of allergic bronchopulmonary aspergillosis. I believe it was inappropriate to admit this patient to the hospital and to subject him to ...

To the Editor: In “The Heart of the Matter” (Nov. 4 issue),¹ Thibault comments that aortic valvular insufficiency can be underestimated if the Doppler probe is not perpendicular to the direction of the jet. In fact, the best Doppler spectral display is ...

To the Editor: I would like to point out a mistake in the figure accompanying Dr. Schwartz's editorial (Jan. 27 issue)¹. As shown in the figure, the glycosyl-phosphatidylinositol (GPI) tail extends through the entire membrane bilayer. This is incorrect. ...

To the Editor: A 50-year-old male physician requested an evaluation for mild discomfort in the left ear that had recurred intermittently for a week. Four days before the visit he had difficulty clearing water from his left ear after swimming. There was ...

This is clearly a book with a point of view, and it must be read as such. It contains the views of members of the Veritas Society, who met in November 1991 to voice their objections to the diet-heart hypothesis (linking diet to heart disease), which they ...

This large book by experts in the field critically examines the scientific and clinical aspects of heart failure. It is timely and comprehensive and accomplishes its goal of bridging the gap between the basic scientist and the clinician.

Heart failure is ...

A little more than a decade ago, a workshop on advanced congestive heart failure was held at the National Institutes of Health. At that time, the armamentarium for treating heart failure was limited. However, there appeared to be a consensus favoring the ...

In recent years physicians have become increasingly aware that symptoms of congestive heart failure may occur in patients with cardiac disease who have normal systolic function. The importance of altered diastolic properties in the genesis of symptoms of ...

The title of this book implies that the anesthesiologist should find it a ready reference pertaining primarily to concerns about anesthesia in patients with “coexisting” heart disease. The editor states in the preface that “this book was written for the ...

This book was produced by members of the Fleischner Society, a group of 62 pulmonary radiologists, pathologists, and clinicians with a common interest in chest disease. As stated in the preface, this is their second effort honoring Dr. Felix G. ...

Vesnarinone for Heart Failure Correspondence, N Engl J Med 1994:330;64-66.. On page 65, Ingrid Grupp, M.D., and Gunter Grupp, M.D., Ph.D., should have been listed as coauthors of the letter from Arnold Schwartz. Also, Dr. Schwartz's degree should have ...

Prehospital Thrombolytic Therapy for Myocardial Infarction Correspondence, N Engl J Med 1994:330;290-291.. On page 290, starting in the third-to-last line of the right-hand column, the group cited should have been “Global Utilization of Streptokinase and ...