Improved obstetric and neonatal interventions and aggressive techniques of resuscitation have gradually improved the survival of preterm infants and lowered the limit of viability¹–¹⁰. Although the prophylactic administration of surfactant has further ...

Indomethacin, a potent inhibitor of prostaglandin synthesis, has been used as a tocolytic agent since the mid-1970s. It crosses the placenta freely¹ and can inhibit the synthesis of prostaglandins in fetal tissues. The use of indomethacin during pregnancy ...

Follicular lymphomas are the commonest subgroup of non-Hodgkin's lymphomas, accounting for 25 to 40 percent of cases¹,². Low-grade follicular non-Hodgkin's lymphoma has an indolent course, and patients survive for a median of 7 to 10 years, but most ...

The hypothesis that more rapid restoration of flow through the infarct-related artery after the initiation of thrombolytic therapy may better preserve left ventricular function and improve survival among patients with acute myocardial infarction has been ...

X-linked lymphoproliferative disease is characterized by vulnerability to diseases induced by the Epstein-Barr virus, including life-threatening infectious mononucleosis, hypogammaglobulinemia, aplastic anemia, and B-cell non-Hodgkin's lymphoma. It is ...

Figure 1. Skin and Nail Lesions in Endocarditis.

Typical subungual (“splinter”) hemorrhage and numerous petechiae on the skin of the abdomen are seen in a patient with staphylococcal endocarditis.

Professional courtesy, typically defined as providing free or discounted health care to physicians and their immediate families, is a custom with deep roots in medical practice. Originally discussed in the Hippocratic Oath, the practice was specifically ...

Rabies (“rage” or “madness” in Latin) has been the object of human fascination, torment, and fear since the disease was recognized in antiquity¹. Improvements in prevention during the past 50 years have led to the almost complete elimination of ...

Presentation of Case

A 28-year-old man was admitted to the hospital because of recurrent ventricular tachycardia.

There was a 12-year history of chronic active hepatitis with cirrhosis for which the patient took prednisone daily. Nine years before entry ...

Regionalization of perinatal care and technological advances in the 1970s were accompanied by the improved survival of preterm infants born after 26 weeks' gestation with birth weights above 750 g. Beginning in the early 1980s, active obstetrical and ...

The foundation of modern therapy for acute myocardial infarction was laid in 1941 by Blumgart et al., who demonstrated that in dogs with transient coronary occlusion, the extent of myocardial infarction was affected by the duration of occlusion¹. As a ...

Professional courtesy, the provision of care without charge to physicians and their immediate families, is a long-standing tradition in the medical profession. The practice, as described in 1803 by Thomas Percival in Medical Ethics, reflects the ...

To the Editor: Woolhandler et al. (Aug. 5 issue)¹ did not analyze the range of hospital administrative expenditures, only the statewide average. Since distributions of financial data are generally highly skewed, the average is rarely typical². Data on ...

To the Editor: Dr. Blumenthal states (Aug. 5 issue)¹ that “One of the most effective ways to exert [physician] leadership may be [for physicians] to participate in the development of administrative systems that make the quality of health care the best it ...

To the Editor: Diss et al. (July 15 issue)¹ described a case of mucosa-associated lymphoid-tissue (MALT) lymphoma presenting in multiple sites over a number of years. Using methods based on the polymerase chain reaction (PCR), they demonstrated a common ...

To the Editor: Kamel et al. (May 6 issue)¹ reported two cases of reversible lymphomas associated with methotrexate therapy for rheumatic diseases. As they noted, several years ago we made a similar observation². Unlike their cases, the lymphoma we ...

To the Editor: With regard to the article by Farley et al.¹ and the editorial by Wessels and Kasper² (June 24 issue): The defects in immune defenses in patients with cancer are extremely heterogenous in type and severity and cannot be simplistically ...

To the Editor: We are concerned by the conclusion of Ramsey et al. (June 17 issue)¹ that aerosolized tobramycin is not only efficacious but also safe. They state that there was no significant difference with regard to the emergence of tobramycin-...

To the Editor: After the publication of our paper “Prenatal Prediction of Risk of the Fetal Hydantoin Syndrome” (May 31, 1990, issue),¹ our laboratory received many requests to assay epoxide hydrolase activity in samples of chorionic villi. Our prior ...

To the Editor: Why do injection-drug users continue to engage in risky behavior in the midst of the AIDS epidemic? Although efforts to reduce such behavior have resulted in declines in the reported frequency of needle-sharing and, to a lesser degree, ...

To the Editor: An advertisement caught my eye in the September 30 issue of the Journal. The advertisement was for a home glucose monitor. Surprisingly, it was on the page facing the lead article concerning the very encouraging results of “tight” glycemic ...

Aminoff has taken great care in crafting a portrait of Charles Edouard Brown-Sequard, a man of many quirks, tremendous intuitive insights, and impressive scientific accomplishments. Immortalized in the eponym that describes the clinical syndrome of spinal ...

This book is a sobering antidote to the intoxicating enthusiasm for genetic solutions to human diseases. The authors place disease in a social context, pointing out that with rare exceptions its occurrence and severity are influenced by socioeconomic ...

This book focuses on an important aspect of organ transplantation. Psychosocial aspects of organ transplantation follow hard upon and often appear in tandem with pioneering medicine and surgery. Issues addressed by consultation-liaison psychiatrists and ...

This book on critical care medicine is approximately half the size of some other recently published works on the topic. It does not provide an encyclopedic listing of disease states, treatments, or procedures. The intent of the editors is revealed in ...

In modern cardiovascular practice, the natural history of almost every major disorder has been radically altered by an explosion of medical and surgical forms of therapy. Thus, the accomplished practitioner must be one who, aided by an abundance of ...

Deaths from cardiovascular diseases, principally acute myocardial infarction and cerebrovascular accidents, have decreased substantially over the past two decades, largely as a result of aggressive antihypertensive therapy, the recognition of the hazards ...

President Clinton's Health Security plan is a distinctively American synthesis. Like universal health insurance in other industrialized countries, it covers a comprehensive set of benefits for all citizens and makes health coverage a right of citizenship. ...

Physicians occupy a pivotal position in the health care system. Economist Victor Fuchs has called them the captain of the ship, responsible for the large majority of decisions that direct the treatment of patients and determine what happens to them¹. ...