There has been lingering concern in the public health community that there may be racial differences in risk factors for coronary disease. The current recommendations for risk-factor modification were derived from numerous observational studies that ...

Convulsions triggered by fever (febrile seizures) are the most common type of seizure, with a prevalence of 3 to 4 percent¹. Febrile seizures frequently recur, with a recurrence rate of 33 percent overall and 50 percent when the first febrile seizure ...

Defining the appropriate treatment for idiopathic membranous nephropathy -- the most common cause of the nephrotic syndrome in adults -- is controversial¹–¹⁵. The course of the disorder is often benign, but it can result in renal failure. Several regimens ...

In patients with asthma, exercise in various forms can induce post-exercise bronchoconstriction. The bronchoconstrictor response in exercise-induced asthma has been attributed to the inhalation of a large volume of inadequately conditioned air, which ...

Charcot-Marie-Tooth disease (CMT)¹,² is the most common inherited peripheral neuropathy, with a frequency of 1 in 2500,³ and is one of the most prevalent autosomal dominant diseases⁴. It is a clinically heterogeneous disorder of the peripheral nerves ...

Figure 1. Three-Dimensional CT Diagnosis of Maxillofacial Trauma.

Spiral computed tomographic (CT) slices (Panel A and Panel B) from which three-dimensional images were reconstructed (Panels C, D, E, and F) were obtained in a 16-year-old boy with facial ...

In recent decades death rates in this country have fallen, but the improvement has not been shared equally. There is a widening gap in the death rate between blacks and whites¹. Although the inverse relation between socioeconomic class and mortality has ...

People with lower socioeconomic status, as measured by indicators such as income, education, and occupation, have higher mortality rates than those with higher socioeconomic status¹–⁵. Although health-related behavior and access to medical care contribute ...

Presentation of Case

A 32-year-old right-handed man was admitted to the hospital because of left hemiplegia.

There was a history of hypertension that dated back for three years or more; antihypertensive medications had been prescribed, but the patient was ...

Anyone who follows the medical literature knows that “socioeconomic status” is a powerful determinant of health. In current jargon, socioeconomic status refers to a mix of factors that shape a person's relative social advantage. It is usually gauged by ...

In 1860 Dr. Jacob Bigelow, a former president of the Massachusetts Medical Society, published Nature in Disease, a compilation of essays that encouraged the medical profession to understand the natural course of disease and to test the value of ...

The clinical use of heparin as an anticoagulant and antithrombotic agent is established practice in prophylaxis against postoperative deep-vein thrombosis, in the initial treatment of overt deep-vein thrombosis, and in the prevention of thrombosis during ...

Reform of the medical care system in the United States is now a political and economic priority. In the current debate, the terms “health care” and “medical care” are often used interchangeably, reflecting a cultural view that they are synonymous. As a ...

To the Editor: In their article on drug-resistant tuberculosis in New York City, Frieden et al. (Feb. 25 issue)¹ demonstrate that cases of such disease are cause for serious concern. I wonder, however, whether the authors studied a representative ...

To the Editor: Iseman and colleagues (Feb. 25 issue)¹ recommend that every patient with tuberculosis in the United States receive directly observed therapy. In 1984 the Mississippi State Department of Health began a pilot program in one of its nine ...

To the Editor: In his discussion of the law and tuberculosis control (Feb. 25 issue),¹ Annas concludes that interventions short of confinement are preferred and that it is “appropriate to use monetary and other inducements to encourage compliance with ...

To the Editor: Klag et al. (Feb. 4 issue)¹ report a strong correlation between the serum cholesterol level measured early in adult life in men and the incidence of cardiovascular disease in midlife. In contrast to other investigators,²–⁴ they did not ...

To the Editor: Studies of the metastatic behavior of cancer suggest that one of the factors influencing the site at which tumor cells lodge is the presence of a special “soil” that favors the survival and growth of these tumor cells. A variety of ...

To the Editor: Iglehart's review of the End Stage Renal Disease Program (Feb. 4 issue)¹ discusses the distressingly high cost of providing diagnosis-specific high-technology care to a small segment of the U.S. population. Iglehart states that the ...

To the Editor: In 1989 we reported that clomipramine was superior to desipramine in reducing hair-pulling symptoms in trichotillomania¹. Three of the 13 subjects completing the initial double-blind crossover trial had complete remissions during the five ...

To the Editor: I started wondering what the cover of the Journal might look like in a generation's time. These are my thoughts.

These two books approach the topic of birth control from very different perspectives. Riddle's work represents a historian's sweep over some millennia; that of Sitruk-Ware and Bardin presents the views of 27 scientists focused on just a few decades. Not ...

The 18 chapters that make up this “first handbook on fetal behaviour” demonstrate once again how technological advances, such as the development of real-time ultrasonographic imaging in the early 1970s, make possible entirely new fields of study. Nijhuis' ...

The cover of A Textbook of in Vitro Fertilization and Assisted Reproduction promises to detail the teachings of the Bourn Hall Clinic -- the in vitro fertilization (IVF) clinic founded by Drs. Patrick Steptoe and Robert Edwards in 1980, two years after ...

With the current epidemic of sexually transmitted diseases and the worldwide problems of genital tract infection in women, this is a timely and important textbook. As pointed out by Dr. Ledger in his foreword, “This is the first text solely devoted to the ...

The Emergence of Drug-Resistant Tuberculosis in New York City Original Article, N Engl J Med 1993:328;521-526.. There are slight discrepancies among Table 2, Figure 1, and the Discussion section. Table 2 is correct: Of the patients with no previous ...