It is now generally accepted that objective tests are mandatory in order to make the diagnosis of clinically suspected acute deep-vein thrombosis of the leg¹–³. Currently, impedance plethysmography performed serially over a one-week period (to detect ...

Postoperative deep-vein thrombosis presents a major clinical threat to patients undergoing hip or knee replacement¹–⁴. In the absence of prophylactic anticoagulation, this disorder occurs in 40 to 60 percent of patients receiving hip implants⁵–⁹ and in 60 ...

The treatment of patients with invasive bladder cancer is undergoing dramatic changes, incorporating many potentially effective and complementary therapies from several disciplines, including transurethral surgical resection, systemic chemotherapy, ...

Reproductive endocrine disorders occur more frequently among women and men with epilepsy than among normal subjects¹–³. In women these disorders have generally been attributed to the epilepsy itself,²,³ rather than to any antiepileptic treatment. Both ...

Light-chain amyloidosis and light-chain deposition disease are closely related processes characterized by tissue deposition of organized (fibrillar) or nonorganized material related to monoclonal immunoglobulin light chains. Both conditions can occur in ...

Figure 1. Sarcoidosis.

This image was obtained by scanning with gallium citrate Ga 67 in a 24-year-old woman with uveitis and iritis, fatigue, night sweats, myalgia, arthralgia, and a nonproductive cough. The study shows intense localization of the tracer ...

National attention is currently focused on the organization of medical care in the United States. Competing groups with different ideas about reorganizing health care advance views based on socioeconomic hypotheses and evaluations of health care systems ...

The frightening pace of the worldwide spread of the human immunodeficiency virus (HIV) demands that priority be placed on the development of an effective vaccine¹. Two distinct populations of viruses responsible for the acquired immunodeficiency syndrome (...

Stage

A 53-year-old painter and construction worker presented to the emergency room with shortness of breath, chest pressure, palpitations, and nocturnal cough. The patient had a four-year history of hypertension and hypercholesterolemia and did not ...

Presentation of Case

A 39-year-old man was admitted to the hospital because of fever, diffuse arthralgia, and purpuric skin lesions.

There was a history of intravenous drug abuse 20 years earlier, during which the patient contracted hepatitis, with ...

In this issue of the Journal, two important aspects of venous thromboembolism are discussed. In one, a joint Canadian-Dutch study, two noninvasive methods of diagnosing deep-vein thrombosis in symptomatic outpatients are compared¹. In the other, a ...

The goal of any treatment for cancer is to achieve the highest possible likelihood of cure and the best possible quality of life. For a number of tumors, radical surgical procedures have been replaced by more conservative and less disfiguring ones, with ...

Immunoglobulins are essential for health. In the absence of these proteins, life-threatening illnesses often occur, as evidenced by the susceptibility of people with congenital or acquired immunoglobulin deficiencies to infection or neoplasia. On the ...

To the Editor: The two studies suggesting a substantial reduction in the risk of coronary heart disease associated with the use of vitamin E supplements (May 20 issue)¹,² provide further compelling evidence about the importance of oxidation in the ...

To the Editor: The report (May 20 issue)¹ of a middle-aged laboratory worker who self-administered a large dose of endotoxin, leading to the development of the septic shock syndrome, raises questions about the patient's subsequent care. The case report ...

To the Editor: Dr. Parrillo (May 20 issue)¹ raises an important issue concerning the use of inhibitors of nitric oxide synthase in septic shock in his article “Pathogenetic Mechanisms of Septic Shock.” The view that these inhibitors may be harmful in the ...

To the Editor: We agree with Clark and Keroack when, in their letter entitled “Pneumococcal Appendicitis in a Man with HIV Infection” (April 29 issue),¹ they assert that “perforating gangrenous appendicitis is rarely a unimicrobial process.” Over a ...

To the Editor: I would like to add several comments to the article on sleep-disordered breathing among middle-aged adults (April 29 issue)¹ and the accompanying editorial².

Dentists represent an untapped resource for screening people at risk for primary ...

To the Editor: We report a case of muscle weakness induced by herbs that is associated with the boom in unconventional therapy. A 69-year-old man had an eight-month history of painless, nonfluctuating weakness, primarily of the lower extremities, without ...

The relation between political leaders' states of health and the institutions of state that they govern are necessarily complex. The authors of this book describe these relations as though a leader, whether a monarch or a democratically elected president, ...

This important book examines the biologic, ecologic, and social factors responsible for the continuing emergence of new viral diseases. It is an update of a 1989 conference sponsored by the National Institutes of Health and Rockefeller University. ...

Three decades ago this book would have been marketed as science fiction. Smallpox was on the verge of extinction, and health officials targeted measles, malaria, and other diseases for eradication. Powerful vaccines and drugs were poised to defeat ...

For the past third of a century, some of the greatest strides in medicine have been made in the area of infectious diseases. The number of causative agents identified and the development of antibiotics have been phenomenal. These achievements gave us a ...

A prodigious amount of information is available regarding the biochemistry, structure, and function of cytokines and their contribution to immune and inflammatory events associated with different diseases. Cytokines in Health and Disease provides a ...

Case Records of the Massachusetts General Hospital (Case 34-1993) Case Records of the Massachusetts General Hospital, N Engl J Med 1993:329;645-653.. On page 645, in Table 1, the vital capacity should have been expressed in liters, not “liters/sec,” as ...

Treatment of Multidrug-Resistant Tuberculosis Review Article, N Engl J Med 1993:329;784-791.. On page 788, in Table 4, the first entry under “Resistance” should have read, “Isoniazid and streptomycin,” not “Isoniazid, streptomycin, and pyrazinamide,” as ...