Preeclampsia, a hypertensive disorder of pregnancy characterized by vasospasm and coagulation abnormalities,¹ is a leading cause of fetal and maternal morbidity and death, especially in underdeveloped countries²–⁴. Low-dose aspirin therapy (60 to 100 mg ...

Treatment with anthracycline-based chemotherapy regimens results in complete remission in 50 to 90 percent of patients with intermediate and high-grade non-Hodgkin's lymphoma and long-term disease-free survival in 30 to 60 percent. Unfortunately, few ...

Acute graft-versus-host disease (GVHD) is a serious problem in recipients of allogeneic bone marrow grafts¹. Several approaches have been used to prevent it. Removal of T cells that are responsible for acute GVHD²,³ resulted in a lower incidence of this ...

Blastomycosis is a relatively common pulmonary and cutaneous mycosis encountered in people living in the Mississippi River basin, around the Great Lakes, and in the southeastern United States¹,². It is estimated that as many as four cases of symptomatic ...

Pseudoxanthoma elasticum is an inherited disorder of connective tissue that is associated with numerous systemic manifestations, including premature coronary artery disease. Without a serologic marker, the diagnosis relies on clinical features and the ...

Figure 1. Pseudoxanthoma Elasticum.

Characteristic skin lesions can be seen in the axilla and anterior to the axilla in a patient with pseudoxanthoma elasticum, an inherited disorder of connective tissue. The lesions are yellow, xanthoma-like papules that ...

As health care costs continue to increase rapidly, both health care providers and consumers have expressed concern that the additional resources used for health services do not provide commensurate increases in health benefits. Adding fuel to this concern,...

The long-held view that homeostatic mechanisms are integrated by the nervous and endocrine systems has recently been expanded by information that these systems interact with the immune system. Immune responses alter neural and endocrine function, and in ...

Presentation of Case

A 62-year-old woman was admitted to the hospital because of nausea, vomiting, and jaundice two weeks after an aortic valvuloplasty.

The patient had had a heart murmur “since birth,” for which she was followed annually, and had ...

Underlying the expectation that physicians, health plans, and other organizations will soon be competing on the basis of the quality as well as the cost of medical care¹ is the fundamental assumption that we know what quality is and how to measure it, ...

The report in this issue of the Journal by Sibai and colleagues¹ highlights the search for a treatment to alter the incidence of preeclampsia. Hypertensive disorders complicate 10 to 12 percent of the 3.5 million pregnancies each year in the United ...

Almost two decades have passed since Kohler and Milstein first applied somatic-cell hybridization to the production of specific murine immunoglobulins (monoclonal antibodies)¹. In clinical oncology, the use of monoclonal techniques has had a substantial ...

It has become a truism that not only does the United States spend more money on health care than do other industrialized nations, but also a substantial portion of this sum is wasted on unproved or ineffective diagnosis and therapy. Not surprisingly, then,...

What causes physicians to change the way they practice? This question is especially important today because physicians' decisions influence not only the health of their patients but also the cost of their care. Thus, the ability to change physicians' ...

To the Editor: Ernst (April 22 issue)¹ provided a comprehensive review of the complex issue of the effectiveness of elective aortic reconstruction for abdominal aortic aneurysms. His presentation, however, was scientifically selective in favor of ...

To the Editor: Cummins et al. (May 13 issue)¹ are to be complimented on their community-based interventional study to assess the efficacy of out-of-hospital transcutaneous pacing in asystole. They demonstrated a twofold increase in survival in the ...

To the Editor: In their comparison of outcomes in men 11 years after heart-valve replacement with a mechanical valve or bioprosthesis, Hammermeister et al. (May 6 issue)¹ found a mortality rate of approximately 25 percent among patients requiring ...

To the Editor: I congratulate Dr. Weinberger (May 13 and May 20 issues)¹ for admirably performing a seemingly impossible task: summarizing recent advances in pulmonary medicine. I disagree, however, with his statement that in patients receiving ...

To the Editor: Pizzo (May 6 issue)¹ recommends careful handwashing before one has any contact with a febrile patient with neutropenia. In a previous review² he stated that it seemed reasonable to restrict such patients to a cooked-food diet in order to ...

To the Editor: Filgrastim (recombinant human granulocyte colony-stimulating factor) is available for the treatment of chemotherapy-induced neutropenia. It is currently being investigated for use in bone marrow transplantation, aplastic anemia, ...

To the Editor: In our study describing the effects of calcium supplementation on bone loss in normal postmenopausal women (Feb. 18 issue),¹ the bone mineral density of the lumbar spine increased significantly during the first six months in both the ...

To the Editor: Much has been written in recent years about the difficulty of attracting students to internal medicine¹. The results of the 1993 National Residency Matching Program again showed a substantial decline in the number of medical students ...

This book is richly illustrated, with 480 color plates. In many respects it is the offspring of Colour Atlas of Haematological Cytology, an earlier work by Hayhoe and R.J. Flemans (3rd ed. London: Wolfe Medical, 1991). Its parentage is recognizable in the ...

We are told in Leviticus that the blood is the life of the flesh. This perception appears to be shared by several viruses that target blood-forming cells that permit their replication. Studies of virus-blood-cell interaction not only improve our ...

More than 500 teams around the world are carrying out bone marrow transplantation (BMT) on a daily basis. This book will undoubtedly find its place on the shelves of attending physicians, fellows, and residents directly involved in BMT. It will also serve ...

The average general surgeon will see only a single soft-tissue sarcoma during his or her career. Only 5000 to 6000 new cases of sarcoma are diagnosed each year, evenly distributed among age groups and accounting for less than 1 percent of all cancers in ...

These two books provide comprehensive information about ovarian cancer and its management. The editors of both books have extensive experience with ovarian cancer, and they have chosen experts to contribute chapters.

The two books are similar in format ...

Breast-cancer management has of necessity become a multidisciplinary specialty. Not only is broad expertise from a number of disciplines required; most often, lifelong commitment to patients is essential to deal with dynamic therapeutic problems.

This 346-...

Infectious Diseases in Somalia Correspondence, N Engl J Med 1993:329;889-890.. On page 890, in lines 11 and 12 of the left-hand column, the dosage of primaquine should have been given as 15 mg per day, not 15 mg per kilogram of body weight per day, as ...