Estrogen therapy is most often received by women soon after the menopause, and the prevalence of use declines as women reach their 60s. On the other hand, the incidence of fractures related to bone fragility increases with age. The rate of hip fracture, ...

The incidence of skin cancers (melanoma and nonmelanoma) has been increasing in many countries recently,¹–³ and may be increased more in the future by ozone depletion⁴. Many public health authorities are initiating primary prevention programs recommending ...

Acquired aplastic anemia is a rare¹ hematopoietic disease of stem cells² that can be treated by bone marrow transplantation or immunosuppressive therapy³–⁶. Survival is better after bone marrow transplantation than after immunosuppressive therapy in ...

Lymphedema, a form of high-protein edema, is a serious, long-lasting, and common problem; there are about 140 million cases throughout the world¹,². Correctly applied, physical methods of treatment rapidly reduce edema fluid,³–⁶ but they require intensive ...

Human infection with Ehrlichia chaffeensis, a recently identified bacterium included in the family Rickettsiaceae,¹,² results in an acute, generally self-limited, febrile illness associated with cytopenia and hepatic-enzyme abnormalities. Several hundred ...

Figure 1. Some Features of Fanconi's Anemia.

The physical and cytogenetic findings in some patients with Fanconi's anemia are shown. Panel A shows the characteristically short thumb; Panel B shows a cafe au lait spot; and Panel C shows chromosomal breaks ...

Scientific advances in the past decade have made the clinical testing of somatic-cell therapy and gene therapy a reality. Early trials in humans suggest that important new diagnostic and therapeutic tools are on the horizon. The objectives of this article ...

Ectopic pregnancy may be the only life-threatening disease in which prevalence has increased as mortality has declined¹. The most prominent theory to explain this phenomenon involves technological advances that allow the diagnosis of pregnancy before ...

Presentation of Case

A 66-year-old woman was referred to the hospital because of progressive weakness of all extremities.

The patient had been well until 19 years earlier, when she experienced the onset of a progressive left footdrop without pain, ...

Almost all physicians and their patients believe that estrogen treatment can prevent osteoporosis. Evidence from the Framingham Study reported in this issue of the Journal supports this hypothesis¹. In women less than 75 years old who had received long-...

In this issue of the Journal, investigators from the Anti-Cancer Council of Victoria, Australia, demonstrate that daily use of a sunscreen with a high sun-protection factor reduces the number of new precancerous solar keratoses and increases the rate of ...

The Centers for Disease Control and Prevention (CDC) reports that women constitute the fastest-growing group of people with AIDS in the United States. Women now represent 13 percent of reported cases. Approximately 80,000 women of childbearing age are ...

“If you torture your data long enough, they will tell you whatever you want to hear” has become a popular observation in our office. In plain English, this means that study data, if manipulated in enough different ways, can be made to prove whatever the ...

To the Editor: Having spent many years actively studying and working with different healing systems in various parts of the world, I feel justified in saying that many unorthodox cures work, usually repeatedly, in ways that defy the placebo effect. The ...

To the Editor: In his book review of American Health Quackery and Guide to the American Medical Association Historical Health Fraud and Alternative Medicine Collection (Dec. 17 issue),¹ Herbert mistakenly equates all “alternative” medical practices with ...

To the Editor: In describing the results of a placebo-controlled study of captopril in patients with left ventricular dysfunction after myocardial infarction, Pfeffer et al. (Sept. 3, 1992, issue)¹ reported that significantly fewer patients given ...

To the Editor: A weekly dose of 250 mg of mefloquine (Lariam) is being used by U.S. forces for chemoprophylaxis against malaria in Somalia. We report two cases of malaria caused by Plasmodium falciparum in U.S. soldiers who were taking mefloquine.

A 23-...

To the Editor: Blackwater fever and acute tubular necrosis in malaria caused by Plasmodium falciparum are assumed to be results of hemoglobinuria. The following case suggests that myoglobinuria may also be responsible.

A 32-year-old man with a history of ...

To the Editor: A new tool in our armamentarium against opportunistic infections in AIDS is always welcome, and the recent trial of atovaquone by Hughes et al. (May 27 issue)¹ demonstrates that this drug will have its place in that struggle. I am ...

This collection of articles about John Benjamin Murphy resurrects an almost forgotten figure in the rise of surgery in the United States. Born in a Wisconsin log cabin in 1857, Murphy eventually became chief of surgery at the Mercy Hospital in Chicago, a ...

The aim of Medical Theory, Surgical Practice is to relate a number of pivotal advances in surgical practice to theories current in medicine and in society in the era in which the advance was made. Thus, the book deals, to no small extent, with the age-old ...

A wise educator once observed that changing a curriculum is as easy as moving a graveyard. That would not come as news to the authors of this book. These two professors from the University of Glasgow are avowed incrementalists, realistically acknowledging ...

Physicians in breathless pursuit of state-of-the-art diagnostic and therapeutic techniques sometimes need to pause and take stock. An examination of how medical specialties evolved can summon reflections on the wisdom and vision embodied in the origins of ...

“Tragedy” is not too strong a word to describe the story this book tells. Those familiar with today's deplorable relations between the medical profession and the legal profession will be surprised to learn that in the second quarter of the 19th century, “...

The authors' intent in this work is to increase the reader's skill in extracting physiologic information from the plain chest film. They state that one source of inspiration was a lecture by a great chest radiologist, Leo Rigler, published in July 1959, ...