Since its introduction in the early 1960s, circulatory arrest has been widely used in centers with expertise in infant open-heart surgery¹–³. A great advantage of this technique is the absence of perfusion cannulas and blood in the operative field. The ...

Current treatment of human immunodeficiency virus type 1 (HIV-1) infection consists exclusively of the nucleoside-analogue reverse transcriptase inhibitors zidovudine, didanosine, and zalcitabine¹–⁸. Unfortunately, the antiretroviral and clinical ...

Diarrhea occurs in 80 percent of patients with the carcinoid syndrome¹–³. Its pathophysiology is poorly understood, but it probably is multifactorial. A variety of tumor products, including serotonin, substance P, histamine, kallikrein, and prostaglandins,...

Joint hypermobility, also known as joint laxity and defined as a range of motion in excess of normal,¹ is common enough to evoke curiosity, but until recently it has been little investigated because of its apparent harmlessness. Historically, it attracted ...

Figure 1. Multiple Brain Abscesses.

Both images are computed tomographic scans (with contrast) of the head of an eight-year-old boy with a 10-day history of headaches, vomiting, fever, altered mental status, and frontal-lobe signs. More than 30 ring-...

Homicide claims the lives of approximately 24,000 Americans each year, making it the 11th leading cause of death among all age groups, the 2nd leading cause of death among all people 15 to 24 years old, and the leading cause of death among male African ...

Hearing loss of a degree sufficient to interfere with social and job-related communication is among the most common chronic neural impairments in the U.S. population. On the basis of health-interview data,¹ it is estimated that approximately 4 percent of ...

Stage

A 53-year-old, previously healthy college professor was brought to the emergency room in status epilepticus. He had no history of seizures.

Response

After giving intravenous medication to stop the seizures, I would obtain some medical and social ...

Presentation of Case

A 61-year-old woman was admitted to the hospital because of fever, jaundice, hepatosplenomegaly, and gallstones.

The patient had been in stable health until three weeks earlier, when a mild chronic headache developed. One week before ...

Last October several bizarre coincidences led to the death of a 16-year-old Japanese exchange student in a suburb of Baton Rouge, Louisiana. The student and his American friend, looking for a Halloween party, missed the correct house by a few doors and ...

Neurologic deficits remain the most dreaded of complications after cardiac surgery. In the past, analyses of outcomes after cardiac surgery have concentrated on survival. Now that techniques of myocardial protection and cardiopulmonary bypass have been ...

It is widely believed that the outstanding virtuosity of the violinist Niccolo Paganini (1782-1840) derived from the remarkable flexibility of his joints, and in particular that of his left hand. He is reported to have been able to bend his thumb back so ...

To the Editor: Malabsorption of antimycobacterial drugs has been reported in one person with AIDS coinfected with Mycobacterium tuberculosis and 26 patients with AIDS coinfected with M. avium complex¹–³. We report an additional 32 instances of drug ...

To the Editor: Erice et al. (April 22 issue)¹ described a patient with symptomatic human immunodeficiency virus type 1 (HIV-1) infection who had a primary infection with a virus resistant to zidovudine. We report the case of a homosexual man in whom ...

To the Editor: The study by Hunninghake et al. (April 29 issue),¹ “The Efficacy of Intensive Dietary Therapy Alone or Combined with Lovastatin in Outpatients with Hypercholesterolemia,” is very misleading. Despite the title of the article, a National ...

To the Editor: We enjoyed reading Dr. Duffy's comments (May 6 issue),¹ particularly with regard to the mechanisms of chest pain in a patient with systemic mastocytosis. We disagree with the statement that the exacerbation of chest pain after the ...

To the Editor: In caring for children undergoing surgery, we noted that some of them had blood glucose concentrations greater than 120 mg per deciliter. To determine whether emotional stress was the cause of these elevations, we studied 28 healthy boys ...

“Critical-incident reports” are short narratives of events judged to be particularly meaningful by participants in the events¹–³. Our medical students wrote such reports at the beginning, in the middle, and in the latter part of their third year, while ...

During Vincent van Gogh's last and most creative years he suffered from an unusual disease with attacks of horrible anxiety, confusion, and aggression, sometimes brought on by absinthe abuse. Once, during a delirious phase, after threatening to kill his ...

Great wits are sure to madness near allied,

And thin partitions do their bounds divide.

-- John Dryden

Medicine has a long tradition of taking an interest in the ailments of the historically notable, in part to enrich its teaching with relevant and memory-...

The title of the book encapsulates its central thesis -- that psychiatry is a branch of medicine. This proposition might seem to be a tautology, yet it reflects a question at the very core of psychiatry: What are the appropriate purview and perspective of ...

In his whimsically titled book, Dr. van Praag has assigned himself the monumental task of reformulating contemporary psychiatric diagnostic methodology, as reflected in the third and third revised editions of the Diagnostic and Statistical Manual of ...

This book contains a wealth of information of practical importance to all who care for patients suffering from psychiatric disturbances. The editors have organized the contributions of the 44 authors into three sections. The first, entitled “General ...

The Increasing Disparity in Mortality between Socioeconomic Groups in the United States, 1960 and 1986 Special Article, N Engl J Med 1993:329;103-109.. On page 107, in Figure 4, the line for “Women, low education” should have been plotted at 5.2 for 1960 ...

Hypokalemic Myopathy Induced by Giardia lamblia Correspondence, N Engl J Med 1993:329;210-211.. The references for the letter were misnumbered. The chapter by Hill should have been reference 1, the article by Beaumont and James reference 2, and the ...