Since the landmark trial of intravenous streptokinase by the Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI) in 1986,¹ there has been no confirmation that other thrombolytic regimens provide additional survival benefit ...

Central diabetes insipidus is a chronic disorder characterized by polyuria and polydipsia due to vasopressin deficiency. The disorder may be familial, idiopathic, or secondary. Familial diabetes insipidus is characterized by autosomal dominant inheritance ...

The bcl-2 proto-oncogene is involved in the 14;18 translocation,¹ a chromosomal abnormality present in 70 percent of follicular lymphomas and 20 percent of diffuse B-cell lymphomas²,³. In this translocation⁴ the bcl-2 gene is juxtaposed with the ...

Figure 1. Metastatic Calcification of the Shoulder in Chronic Renal Failure.

A 32-year-old man with chronic renal failure (from IgA nephropathy) being treated with maintenance hemodialysis began to take his phosphate-binding medications irregularly, and ...

The more than half a million Americans receiving long-term anticoagulant therapy face unnecessary risks of bleeding or thromboembolism because of variability in the commercial thromboplastins used by clinical laboratories to determine prothrombin times. ...

Acute myocardial infarction is the most common cause of death in the United States and in almost all Western industrialized countries. Although unadjusted rates of mortality due to myocardial infarction in the United States have been falling in recent ...

Stage

A 19-year-old female college student who had just returned from a vacation at a resort in Mexico was admitted to the hospital with a three-day history of fever, muscle and joint pains, and a generalized rash.

Response

My first concern would be to ...

Presentation of Case

A two-year-old boy was admitted to the hospital because of cervical lymphadenopathy and fever.

He had been born to a 35-year-old woman by normal spontaneous vaginal delivery at 39 weeks (her third pregnancy). Because of thick meconium ...

Acute myocardial infarction is the most common cause of death in most Western countries. The clinical description of acute myocardial infarction by Herrick¹ in 1912 suggested that acute coronary thrombosis was responsible. Indeed, the possibility of ...

In the 1992 Shattuck Lecture, Congressman John Dingell of Michigan woefully admits that “congressional hearings are rather blunt instruments, poorly suited to making fine distinctions of fact”¹. One would assume that Congressman Dingell would take ...

To the Editor: . . . I was extremely disappointed by the complete lack of attention to the use of nurse practitioners and physician's assistants as primary care providers in the Sounding Board articles in the March 4 issue of the Journal¹–³. Physicians ...

To the Editor: In his Shattuck Lecture as published in the Journal (June 3 issue),¹ Congressman John Dingell says that the Subcommittee on Oversight and Investigations of the U.S. House of Representatives, which he chairs, has “looked only at clear-cut ...

To the Editor: Treatment of histiocytosis X is palliative at best. It includes corticosteroids, alkylating agents, antimetabolites, vinca alkaloids, and irradiation¹. Since 2-chlorodeoxyadenosine, a purine substrate analogue active against lymphoid ...

To the Editor: In his review of open-angle glaucoma (April 15 issue),¹ Dr. Quigley concluded that “the available data from clinical studies suggest that there is a significant reduction in the rate of initial injury when eyedrops are used to lower ...

To the Editor: Do physicians, nurses, allied health professionals, and members of the general public systematically choose more aggressive treatment for patients they do not know and family members than they would want for themselves?

To answer this ...

This massive book of more than 500 pages, with 50 contributors, is a fitting tribute to the work of Geoffrey Rose, who retired two years ago from the position of professor of epidemiology at the London School of Hygiene and Tropical Medicine. Rose's ...

In preparing this book, Gravanis recruited 21 contributors, including 16 from Emory University, to produce 17 chapters, 13 of them coauthored by the editor himself. Each is introduced by a neat outline before proceeding, usually successfully, to cover the ...

This oversized, magnificently produced book is a major publishing event. The distinguished editor has assembled nine contributors to produce seven sections, all but one by a single eminent author. It is unusual for every contributor to a multiauthored ...

The chief difference between this new book and other textbooks on the subject of vascular medicine is that the first 400 pages are devoted to an in-depth discussion of the biologic features of blood vessels and the pathophysiologic aspects of vascular ...

Physicians from all medical specialties are united in a common goal of preventing, diagnosing, and treating venous thromboembolism. The 25 chapters in Prevention of Venous Thromboembolism address these issues as they pertain to both medical and surgical ...

The history of vasculitis is replete with redefinition, “evolution,” and recategorization. In the past few years, such changes have been promoted by the recognition of antineutrophil cytoplasmic autoantibodies, which are found in the blood of patients ...