Allogeneic marrow transplantation is an accepted form of treatment that can provide a cure for patients with hematologic cancers, syndromes of bone marrow failure, and congenital disorders of the lymphohematopoietic system¹,². This type of treatment, ...

Most previous studies of the effect of diet on risk factors for cardiovascular disease or events related to heart disease have considered the intake of fat, cholesterol, and other nutrients¹. However, little attention has been paid to the intake of ...

Restenosis after coronary angioplasty is a major clinical problem. Within six months, clinically important stenosis recurs at the site of angioplasty in 35 to 45 percent of patients who have undergone a single-vessel procedure, and in 50 to 60 percent of ...

Acute myeloid leukemia (AML) is a neoplastic disease of malignantly transformed hematopoietic progenitor cells. The malignant clone outgrows the normal hematopoietic cells, resulting in a predominance of immature cells in the hematopoietic tissue that are ...

Figure 1. Nail in the Brain.

“Scout” films for a computed tomographic scan of the head show a nail in the brain of a stuporous, inebriated man seen in the emergency department. Examination revealed a mild right hemiparesis, which persisted after he became ...

Global limits have been suggested as a means of curbing growth in health expenditures¹. Medicare's recent physician-payment reform incorporates this idea in its volume-performance standard². The volume-performance standard is intended to give physicians ...

The recognition that the restoration of patency to occluded blood vessels can improve clinical outcomes has led to intense interest in the formation and dissolution of platelet thrombi and in the pathobiologic features of vascular repair after an injury. ...

Stage

A 24-year-old woman in the 21st week of her first pregnancy was admitted to the hospital with severe leg edema. Three years earlier, after arthritis and a facial rash had developed, a diagnosis of systemic lupus erythematosus had been made, and she ...

Presentation of Case

A 23-year-old man was admitted to the hospital because of fever, bilateral pulmonary infiltrates, and worsening hypoxia.

The patient was apparently in excellent health until about one week earlier, when a dry cough developed, with a ...

The number, nature, and distribution of generalist physicians will be a focus of considerable attention as we restructure our health care system. Inner cities and rural areas have too few of them, growing health maintenance organizations find it ...

In the wake of the Korean War, a controversy developed over the needs of the armed services for medical officers and the needs of hospitals for interns and residents. To satisfy both parties and be fair to the young men who were subject to selective ...

The failure to fill several prestigious medical house officerships in 1987 and the subsequent steady decline in interest in internal medicine among medical students has led, over the past five years, to convulsive self-examination by program directors and ...

It is widely agreed that for optimal delivery of health care, half or more of all doctors should be primary care physicians¹,². Nevertheless, unmoved by considerations of national need, a high and increasing proportion of graduates of U.S. medical schools ...

To the Editor: Berkel and colleagues (June 18 issue)¹ performed a population-based cohort-linkage study. A cohort of 11,676 women who underwent cosmetic breast augmentation was compared with the cohort of all 13,552 women in Alberta, Canada, in whom a ...

To the Editor: Dr. Granai's recent Sounding Board article, “Ovarian Cancer -- Unrealistic Expectations” (July 16 issue),¹ succinctly highlights the problem of performing excessive screening tests for diseases for which we have no efficacious treatments. ...

To the Editor: The reports by Cheung et al.¹ and O'Connor et al.². (Oct. 22 issue) that the repeated administration of (±)-salmeterol¹ or (±)-terbutaline² results in diminished protection against bronchoconstrictor stimuli, despite sustained ...

To the Editor: Parathyroid hormone-related protein is produced by tumors associated with hypercalcemia and by a variety of normal tissues including lactating breast tissue¹. We describe a woman who had hypercalcemia associated with elevated serum ...

To the Editor: In his article (March 12, 1992, issue)¹ on the public health measures to control the diphtheria epidemic in the early decades of this century, Kleinman identified an important element of the campaign as the positive light in which ...

To the Editor: The proliferation of mail-order pharmacies is accompanied by a potential danger. A patient recently requested a medication refill. I was instructed to place a renewal label provided for me on my blank prescription form and then to sign and ...

Malaria presents a public health paradox. Although it is inarguably the most prevalent infectious disease and one of the foremost impediments to social and economic development in the world, governments of malarious countries and the international ...

In Miasmas and Disease, Carlo Cipolla provides a fascinating glimpse of illness, health care, and prevention in early-17th-century Italy. The first and concluding chapters set up the author's premise and draw his conclusions about the inability of the ...

A lengthy introduction and a rondo capriccioso of 12 discrete essays around a unifying theme form this interesting and surprisingly current book. The theme is the historical perception of pestilence, from the first classical report -- Thucydides' ...

Dirt and Disease is a medical and social history of polio-myelitis in the United States in the early 20th century. Polio cases began to increase in Western Europe and the United States around the turn of the century and reached a terrifying peak in 1916, ...

Historians of medicine in Africa often claim that biotechnology and improved public health make up the most important legacy of colonialism. Maryinez Lyons' Colonial Disease describes the draconian measures taken by the Belgians in an attempt to check the ...

The history of the Centers for Disease Control (CDC), now the Centers for Disease Control and Prevention, is a compelling subject. Not only has this agency of the United States Public Health Service become an important and highly visible institution, but ...

Acyclovir: A Decade Later. On page 783, in Table 1, the entry in the column headed “Route and Dosage” for a normal host with varicella infection should have read, “800 mg/kg orally 4 times/day for 5 days (maximal dose, 3200 mg/day).”

Clinical Manifestations and Predictors of Disease Progression in Drug Users with Human Immunodeficiency Virus Infection. On page 1701, in Table 5, in the column headed “Oral Candidiasis and Bacterial Infections,” the last value in the column should have ...

Images in Clinical Medicine: Lyme Disease. Philip J. Molloy, M.D., who is affiliated with Tufts University School of Medicine in Boston, should have been listed as a submitter along with Mark S. Klempner, M.D. We regret the error.