Despite improved methods of viral attenuation of plasma-derived clotting-factor concentrates in recent years, the transmission of certain blood-borne viruses remains a potential problem. This conclusion is supported by recent reports of transmission of ...

The value of supplementation of calcium intake in the prevention of osteoporosis remains uncertain¹,². Calcium intake is positively related to calcium balance,³,⁴ and calcium supplementation benefits appendicular cortical bone mass⁵–⁹. The axial skeleton, ...

Hepatitis C virus (HCV), an RNA virus first identified in 1989,¹,² is a major cause of both transfusion-associated and sporadic non-A, non-B hepatitis³. Persistent infection occurs in approximately 50 percent of patients and may result in chronic active ...

Myotonic dystrophy is an autosomal dominant disorder with an incidence of 1:8000¹. Its manifestations include muscle wasting, myotonia, cataracts, intellectual impairment, and cardiac conduction defects. The median age of patients at the onset of symptoms ...

Myotonic dystrophy is a multisystem disorder that is transmitted in an autosomal dominant fashion and is characterized by muscular weakness and atrophy, clinical and electromyographic evidence of myotonia, ocular cataract, and various other abnormalities, ...

Figure 1. Membranous Glomerulonephritis.

A transmission electron micrograph (Panel A) shows a cross section of a glomerular capillary loop with the typical changes of membranous glomerulonephritis (x5300). Large, electron-dense deposits are visible on the ...

The myotonic muscle disorders represent a heterogeneous group of clinically similar diseases sharing the feature of myotonia: delayed relaxation of muscle after voluntary contraction (action myotonia) or mechanical stimulation (percussion myotonia). In ...

Gynecomastia, a benign enlargement of the male breast due to proliferation of the glandular component, is a common clinical condition. It may be an incidental finding on routine examination or may present as an acute unilateral or bilateral painful tender ...

Presentation of Case

A boy six years and two months old was admitted to the hospital because of sexual precocity, polyostotic fibrous dysplasia, and cafe-au-lait spots.

The boy was born after a 37-week, uncomplicated pregnancy to a 23-year-old ...

For the past 10 years, both scientists and the lay public have been subjected to a spate of claims and counterclaims about the value of ensuring an adequate intake of calcium throughout life. Although the role of calcium in the health of adult bone has ...

The combination of antigens with antibodies to form immune complexes and their localization within the glomerulus have aided the study of immune mechanisms of tissue damage and provided a cornerstone for the clinical classification and treatment of many ...

Some patients with cervical spinal cord injuries ask to die. It is generally held that a competent, informed adult has the right to forgo medical treatment, even life-sustaining therapy¹. Furthermore, respect for patients' autonomy is not only a ...

To the Editor: In response to charges of intellectual suppression reported in Newsweek,¹ your editorial (Oct. 22 issue)² comments on a paper rejected by the Journal that was recently published elsewhere³. This work presents the hypothesis that neonatal ...

To the Editor: Pereira et al. (Sept. 24 issue)¹ recommended that organs from donors with antibodies to hepatitis C virus (HCV) not be used, even in anti-HCV-positive recipients, because of the heterogeneity of HCV and because the safety of these ...

To the Editor: Lipshultz and colleagues (Oct. 29 issue)¹ studied cardiac dimensions and function in children infected with the human immunodeficiency virus (HIV) and concluded that progressive left ventricular dilatation occurred independently of any ...

To the Editor: Although it is of historical interest, the paper by Laffel et al. (Oct. 22 issue)¹ is of limited contemporary relevance. It reflects nothing more than the importance of the “period effect” in the assessment of forms of medical technology. ...

To the Editor: We recently encountered a patient who survived ethylene glycol poisoning with an arterial-blood pH of 6.46.

A 44-year-old woman drank approximately 720 ml of ethylene glycol in the form of antifreeze. She had previously attempted suicide ...

To the Editor: Dr. Gellert makes several errors of fact and gives a controversial opinion in his letter, “Snake-Venom and Insect-Venom Extractors: An Unproved Therapy” (Oct. 29 issue)¹. He is correct in stating that the application of suction to ...

The divining of the presence of a deep-seated malady from the appearance and relations of cells in a small specimen of liver tissue conjures up an image of ancient ritual and magic. Perhaps this is why liver-biopsy interpretation is viewed by many (...

Both these works are major textbooks that will interest all physicians concerned with gastroenterology and gastroenterologic surgery. Both are intended to serve as atlases of gross and microscopical pathology as well as reviews of the classic pathological ...

Advances in biotechnology during the past two or three decades have tremendously altered the ways in which physicians care for patients with gastrointestinal bleeding, and it is this premise that has motivated Sugawa, Schuman, and Lucas to develop a ...

The integration of medical, surgical, and radiation oncology is central to the management of gastrointestinal solid tumors. This combined-treatment approach is the guiding principle of Gastrointestinal Oncology, a useful reference for all physicians who ...

It is refreshing to find a book whose preface warns readers of the book's limitations. The author points out that he has restricted his review to studies of gastric physiology performed in the period between 1777 and 1975. He states that “some readers may ...

One of the most exciting recent advances in gastroenterology has been the elucidation of the role of a novel spiral bacterium in peptic ulcer disease and gastritis. The organism, now known as Helicobacter pylori, has caused us to reexamine our ...