The survival of infants and very young children with brain tumors is significantly worse than that of older children, both overall and for specific types of tumor¹,². These infants are also at risk for substantial treatment-related neurotoxicity, ...

Pulmonary hypertension is often a progressive condition, characterized by a relentless increase in pulmonary vascular resistance that ultimately leads to right-heart failure and death. Although the initiating factors may differ widely in patients with ...

Endobronchial infections with Pseudomonas aeruginosa, which contribute to progressive obstructive airway disease, are a major cause of morbidity and mortality among patients with cystic fibrosis¹. Aminoglycosides active against P. aeruginosa penetrate ...

Bone loss leading to fractures at sites such as the spine, hip, and ribs is a well-recognized complication of corticosteroid therapy¹–⁵. When high doses are used, loss of bone from sites such as the vertebrae can be rapid, with compression fractures ...

Protein S is a vitamin K-dependent plasma protein involved in the regulation of the protein C anticoagulant pathway,¹ the system responsible for the inactivation of factors Va and VIIIa². Protein S functions as a cofactor for activated protein C by ...

Figure 1. Colocolic Fistula.

A double-contrast barium enema in an asymptomatic 31-year-old woman with a history of Crohn's colitis shows a colocolic fistula in the transverse colon (curved arrow). The inset shows the fistula at a higher magnification. The ...

Endometriosis is a common disorder, yet it is among the most enigmatic of gynecologic diseases. The literature on endometriosis is extensive, though often contradictory or inadequate, and reflects our frequent inability to decipher even the most ...

Presentation of Case

A 56-year-old woman was referred to the hospital because of male-pattern baldness and hirsutism.

The patient's menarche had occurred at the age of 13 years, and her menses were regular in the absence of premenstrual molimina or ...

Much of the current apprehension about health care reform stems from the assumption that a universal and comprehensive health care system would necessarily cost more than we are now spending. The assumption is reasonable; after all, we would be expanding ...

Infants and young children with primary brain tumors pose a unique moral and medical dilemma. For parents and physicians alike, the late neurotoxic effects of radiation therapy in children whose nervous systems are in a critical stage of development are ...

Osteoporosis is the most serious side effect of long-term corticosteroid therapy. The bone mass in corticosteroid-treated patients is reduced in the forearm, spine, and proximal femur, with more loss in trabecular than in cortical bone. The bone mass lost ...

To the Editor: In their review article on head and neck cancer, Vokes et al. (Jan. 21 issue)¹ cite my editorial² as indicating that oral erythroplasia is premalignant and carries a higher risk of transformation to invasive carcinoma than leukoplakia.

...

To the Editor: In their study of cigarette smoking during radiation therapy in patients with head and neck cancer Browman et al. (Jan. 21 issue)¹ did not provide any details about their patients' smoking behavior during radiation therapy or their ...

To the Editor: Ballem and colleagues (Dec. 17 issue)¹ make important contributions to the understanding of human immunodeficiency virus (HIV)-related thrombocytopenia, emphasizing the role of decreased production of platelets, possibly due to viral ...

To the Editor: The editorial by Dr. Balkany on cochlear implants (Jan. 28 issue)¹ makes outdated and incorrect assertions about American Sign Language and the education of deaf children. Dr. Balkany claims that Public Law 99-457 mandates treatment for ...

To the Editor: While providing an excellent overview of the Medicare system, Iglehart (Nov. 12 issue)¹ glosses over the effects of prospective payment on medical practice by summarily stating that no “systematic pattern of diminished quality” of care has ...

To the Editor: The Clinical Problem-Solving case “Weak Reasoning: Diagnosis by Drug Reaction” (Feb. 4 issue)¹ underscores how essential a focused history is in the initial evaluation of an acutely ill patient. Given the amount of effort that went into ...

There is ample reason to be alarmed about the emergence of antibiotic-resistant microorganisms. Stuart Levy provides an informed account of how the antibiotic miracle, which began only 50 years ago, is now threatened by the extraordinarily casual manner ...

The authors of Medical Mycology, authorities in clinical mycology, state that their book is directed toward a broad audience. It encompasses a vast amount of information about increasingly important fungal infections in normal and immunocompromised hosts.

Endocarditis holds great fascination for physicians specializing in infectious diseases, but the question to be asked is whether we need another book on the topic. In each of the major textbooks of medicine and in both of the best-known textbooks on ...

This portable, readable, and scholarly book gives evidence of impressive analytic erudition on the part of the author. Her general theme is the multiple factors, attitudes, and reactions that shape society's behavior when epidemics arrive; her particular ...

In writing this book, Wilson took on a major challenge: to describe the global geography of infectious diseases. As she points out in the preface, “This is the book I sought ten years ago and could not find.” In fact, Professor Brian Maegraith of the ...

A lot is promised in the preface to this book, and at least in part, the author delivers. The book is intended for an audience that has some background in statistics, but not necessarily for those who wish to pursue the subject with mathematical rigor. ...

Case Records of the Massachusetts General Hospital (Case 7-1993) Case Records of the Massachusetts General Hospital, N Engl J Med 1993:328;496-502.. The serum testosterone levels reported in SI units on pages 496 (left column, third paragraph, line 9) and ...

2-Chlorodeoxyadenosine for Patients with B-Cell Chronic Lymphocytic Leukemia Resistant to Fludarabine Correspondence, N Engl J Med 1993:328;812-813.. On page 813, in the left-hand column, beginning in line 9 of Drs. Juliusson and Liliemark's reply, the ...

Treatment of Non-Hodgkin's Lymphoma Review Article, N Engl J Med 1993:328;1023-1030.. On page 1030, reference 38 should have included E. Montserrat as its lead author.