Bismuth subsalicylate has been in common use in the United States for more than 75 years as an over-the-counter treatment for diarrhea,¹ but only recently have its efficacy and safety been assessed through controlled clinical trials. Controlled studies ...

A group of patients who have angina-like chest pain, ischemic ST-segment depressions on their electrocardiograms during exercise testing, angiographically normal coronary arteries without coronary-artery spasm, and normal ventricular function has been ...

Asthma is the most common chronic lung disorder in children; it affects approximately 2 million to 5 million children in the United States. Exposure to environmental tobacco smoke has been reported to affect children with asthma adversely in a variety of ...

Skin diseases, including adverse reactions to drugs, are thought to be more common among patients with human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS) than among other persons,¹ but the differences in the ...

Figure 1. Zidovudine Myopathy.

A muscle-biopsy specimen from a 33-year-old man who had been treated with zidovudine for 24 months shows an accumulation of fine reddish granules in the sarcoplasm, corresponding to mitochondria in atrophic fibers (trichrome,...

Diabetes mellitus is a disease of metabolic dysregulation, most notably abnormal glucose metabolism, accompanied by characteristic long-term complications. The complications that are specific to diabetes include retinopathy, nephropathy, and neuropathy. ...

Much is known about the replication of the human immunodeficiency virus type 1 (HIV-1) from the time of cell attachment to the release of mature virions (Figure 1), and drugs that interfere with many of the steps in HIV replication have been developed and ...

Presentation of Case

A 30-year-old man was admitted to a hospital because of a chronic cough and increasing exertional dyspnea.

The patient had been well until 18 months earlier, when a monarticular arthritis developed in the right second finger after he ...

The discovery in the mid-1960s of the coupled transport of sodium and glucose across the intestinal mucosa led directly to the development of oral rehydration therapy, which has become the critical component of effective treatment of acute diarrhea¹. This ...

Coronary angiograms are found to be normal in approximately 10 to 20 percent of patients undergoing cardiac catheterization to evaluate angina-like chest pain. Although their prognosis is good,¹ most of these patients continue to experience chest pain ...

Research on the hazards of smoking has turned recently to the association between exposure to environmental tobacco smoke (passive smoking) and adverse health events, including lung cancer,¹,² other respiratory diseases,³ and even brain tumors in children^...

To the Editor: In their discussion of prenatal diagnosis and the role of the “triple test” in screening for Down's syndrome, D'Alton and DeCherney (Jan. 14 issue)¹ stated that the triple test “can identify approximately 60 percent of cases of Down's ...

To the Editor: Of the 493 episodes of acute bacterial meningitis in adults described by Durand et al. (Jan. 7 issue),¹ 52 episodes were included because of a compatible clinical picture plus pleocytosis with at least 100 neutrophils per cubic millimeter, ...

To the Editor: As Afzalpurkar et al. (Dec. 24 issue)¹ note, many features of the chronic idiopathic diarrhea they describe also occur in Brainerd diarrhea, a chronic diarrheal syndrome described after outbreaks in Minnesota and Illinois²,³. The authors ...

To the Editor: The Brief Report by Narula et al. (Jan. 14 issue)¹ highlights the frequency with which myocarditis masquerades as myocardial infarction. While we were performing a meta-analysis of patients with myocarditis presenting as myocardial ...

To the Editor: Is it not time to read between the lines? The recent partial retraction of the preliminary, enthusiastic report after additional follow-up by the Parkinson Study Group (Jan. 21 issue)¹ has greatly diminished the previous claims of a ...

To the Editor: The article by Janssen et al. (Aug. 13 issue)¹ and the letter by Lurie et al. (Dec. 17 issue)² raise important issues with regard to the effectiveness of widespread screening for the human immunodeficiency virus (HIV) in acute care ...

To the Editor: Recently, Gellert and colleagues expressed strong concern about office-based test systems for HIV, believing that such tests will compromise effective programs of AIDS surveillance and prevention¹. We question their judgment. As the HIV ...

Asking a neuropathologist to review Greenfield's Neuropathology is like asking an art critic to review the Statue of Liberty. Like the Statue of Liberty, Greenfield has a monumental quality. But if the Statue of Liberty came out in a fifth edition that ...

A 1400-page textbook by a master clinician and teacher with unparalleled experience in both hospital and ambulatory child neurology has to be taken seriously and can be consulted with confidence. This was so for Ford's Diseases of the Nervous System in ...

At first glance, a book called Drug-Induced Movement Disorders may inspire the question, How specialized can one get? If one considers this work a bit longer, however, one realizes the importance of such a book, especially (but certainly not exclusively) ...

This book is directed primarily at the behavioral aspects of Parkinson's disease, although there is a brief introductory section containing a general overview of the disorder. Subsequent sections, each containing four to six chapters, deal with cognitive ...

It might be argued that we could somehow make do without two more textbooks on pediatric neurology. After all, numerous books are already available, ranging in detail from simplistic to encyclopedic. In addition to their shared topic, both Pediatric ...

These are exciting times for investigators of neuromuscular diseases. With the explosion of information about the human genome, we are advancing on the mysteries of many diseases, such as Duchenne's muscular dystrophy, that were formerly thought to be ...

Dr. Weiner addresses this textbook “specifically to practicing neurologists and neurology residents.” However, many chapters (such as those on metabolic encephalopathies, seizures, central nervous system infections, alcoholism, drug dependence, and ...

Spinal Bone Loss and Ovulatory Disturbances. In Table 2, on page 1224, in the values for “Luteal-phase analysis,” the number of women with normal cycles should have been 6 for those normally active and 5 for those who were consistent runners; the number ...

Case Records of the Massachusetts General Hospital (Case 2-1993) Case Records of the Massachusetts General Hospital, N Engl J Med 1993:328;121-128.. On page 128, in the addendum, the first sentence should have read, “The band seen at the origin on the ...