In 1985, about 3 million postmenopausal women in the United States were using hormone-replacement therapy to alleviate symptoms associated with menopause¹. More than 20 studies have been conducted to assess the effects of this therapy on coronary heart ...

Chemotherapy-induced emesis is thought to be mediated by receptors located in the chemoreceptor trigger zone of the area postrema and in the gastrointestinal tract. Until recently, dopamine D₂ receptors were considered the most important, but the ...

Ondansetron, a serotonin antagonist, is superior to virtually all other regimens as an antiemetic in clinical trials¹–⁷. The efficacy of serotonin-antagonist antiemetics in patients receiving highly emetogenic chemotherapy regimens has been studied, and ...

Syncope is a common medical problem, and cardiovascular abnormalities probably constitute the most common basis for unexplained syncope¹–⁴. It has recently been shown that head-up tilt testing, with or without an infusion of isoproterenol, can be used to ...

Figure 1. An Amyloid Deposit in the Shoulder.

A subcutaneous amyloid deposit is shown (arrow) in a patient with a three-month history of weight loss and multiple subcutaneous masses.

In the past decade there has been a great deal of interest in the circumstances of a person's final days and months and in the amount of health care resources expended in the final year of life¹–⁹. In 1978, 28 percent of Medicare program expenditures were ...

Our understanding of glaucoma has undergone dramatic changes in the past decade. The ferment has derived from new epidemiologic information, improved diagnostic methods, and developments in surgical and drug therapy. This review concentrates on primary ...

Presentation of Case

A 58-year-old man was admitted to the hospital because of recurrent gastrointestinal bleeding.

The patient had been in stable health until 27 months earlier, when hematochezia developed. His physician found that he was depressed and ...

Although current epidemiologic evidence overwhelmingly supports the notion that estrogen-replacement therapy protects postmenopausal women against coronary artery disease, the appropriate treatment of these women with gonadal steroids remains ...

As is often the case, many therapies in medicine are prescribed on the basis of assumptions or logical deductions but without data to support their use. For example, in neurocardiogenic syncope, in which hypotension is associated with paradoxical ...

To the Editor: Agnello et al. (Nov. 19 issue)¹ report the detection of hepatitis C virus (HCV) RNA in serum samples from 16 of 19 patients with type II cryoglobulinemia. Using three different assays, they demonstrated antibodies to HCV in the samples ...

To the Editor: Drs. White and Likavec have provided a useful review of the management of head injury (Nov. 19 issue),¹ but I was startled to read their advice that “aside from truly asymptomatic patients in the low-risk group, all should undergo CT [...

To the Editor: Adrenoleukodystrophy is a sex-linked disorder in which very-long-chain fatty acids accumulate in all body tissues¹. For this reason, a variety of diets have been formulated to lower the levels of these acids. One diet includes Lorenzo's ...

To the Editor: Gordeuk et al. (Nov. 19 issue)¹ suggest that iron deficiency may protect against malaria. It does not. Of 101 children with malaria and anemia studied in Kenya, 15 had iron deficiency². The development of malaria was not impaired because ...

To the Editor: We must call to your readers' attention an error that occurred during the editing of our recent letter to the Editor (Feb. 11 issue).¹

In our Table 1, the categories of patients with clotting disorders should have been labeled “treated” (...

To the Editor: The professions make such a fuss about confidentiality and privileged information that the naive layperson invariably believes that lawyers, doctors, and members of the clergy would rather face any horror than breach the confidence of ...

If President Bill Clinton were a reader of old-fashioned Western yarns instead of mysteries and even loftier books, he would know by now how to establish the best of all possible health care systems for all of America's citizens. Rather than propose his ...

Avoiding the many pitfalls in editing a textbook of psychiatry requires the balance of a tightrope walker, the flexibility of an acrobat, a solid, no-nonsense grasp of accurate information that resembles the stolid gait of an elephant, the coordination of ...

The psychiatrist who ventures beyond the consulting room or hospital ward takes on a considerable challenge. Our training does not automatically equip us to make well-reasoned judgments in other disciplines. The careful writer knows this, yet with ...

Psychiatric nomenclature and diagnosis have undergone dramatic changes over the past 20 years. This was exemplified by the release of the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) in 1980 (Washington, D.C.: ...

Although the inspiration for this thoughtful book came from the theme of the American Psychiatric Association's 1989 annual meeting -- “Overcoming Stigma” -- it moves well beyond those presentations to include important new material on the issue of stigma ...

If an artificial rose is placed before a subject who has an allergy to the flower, a “rose cold” may be provoked. In other words, suggestion can elicit the entire immune reaction of allergic rhinitis in certain patients. Asthma, hay fever, and a variety ...

Research on schizophrenia is experiencing a growth spurt at the moment. Several areas, such as epidemiology and neuropsychology, are undergoing a radical overhaul. Others, such as structural imaging and neuropathology, continue to produce new findings. As ...

Prevention and Treatment of Pneumocystis Pneumonia. On page 1856, in the left-hand column, the sentence beginning 12 lines from the bottom should have read, “Toxic effects occurred somewhat earlier in the higher-dose group than in the lower-dose group (...

Association between Polymorphism of the Glycogen Synthase Gene and Non-Insulin-Dependent Diabetes Mellitus Original Article, N Engl J Med 1993:328;10-14.. Alan M. Permutt, M.D., should have been acknowledged in the acnowledgement paragraph on page 14 for ...