Despite the initial observation of serious hemodynamic consequences of right ventricular infarction nearly two decades ago,¹ this condition has received little clinical attention until recent years²–⁴. Postmortem studies revealed that there is right ...

Reading disability is an unexpected difficulty in learning to read despite normal intelligence and the opportunity to learn with competent instruction. It cannot be attributed to general health problems, emotional disturbances, or sensory deficits. ...

Attention deficit-hyperactivity disorder is one of a group of disruptive behavior disorders that also includes conduct and oppositional disorders¹. The major symptoms are motor restlessness, impulsiveness, inattention, and distractibility. Persons with ...

The development of curative combination chemotherapy for patients with advanced stages of aggressive non-Hodgkin's lymphoma has been one of the major successes of cancer therapy during the past two decades. First-generation regimens, which generally ...

Atypical mycobacteria have been widely recognized as human pathogens only since the 1950s¹. Multiple organs can be involved, in particular the skin and bones. However, disseminated infection is usually observed only in immunodeficient hosts. We describe a ...

Figure 1. Giardia lamblia.

Electron micrographs show a duodenal-biopsy specimen from a 29-year-old student of veterinary medicine with a history of fatigue, abdominal pain, and chronic diarrhea that prompted tests for Whipple's disease and Crohn's ...

There has recently been a resurgence of interest in reforming the health care system in the United States. Policy makers have been looking to the national health systems and cost-containment mechanisms in other industrialized nations, particularly Canada ...

The term “chronic obstructive pulmonary disease” (COPD) refers to a spectrum of chronic respiratory diseases characterized by cough, sputum production, dyspnea, airflow limitation, and impaired gas exchange. Most often associated with cigarette smoking, ...

The disorders classified as non-Hodgkin's lymphoma are increasing in frequency in the United States, with more than 35,000 cases diagnosed annually. In recent years, there have been numerous advances in our understanding of the biology of these disorders ...

Presentation of Case

A 74-year-old woman was admitted to the hospital because of hypercalcemia and an osteolytic bone lesion.

The patient had been in good health until six years earlier, when hypercalcemia was discovered. The alkaline phosphatase was ...

Important changes have taken place in the care of patients with acute myocardial infarctions. The concept that ischemic myocardium can be reperfused by means of thrombolytic therapy or angioplasty has fundamentally changed our approach to such patients; ...

Attention deficit-hyperactivity disorder is the newest name for a clinical syndrome familiar to physicians, psychologists, and educators. The disorder is characterized by impulsiveness, distractibility and inattentiveness, aggressiveness, intrusiveness, ...

To the Editor: On behalf of practicing physicians, I want to thank the editors for reviewing the entire issue of Systeme International (SI) units (July 2 issue)¹ and for using common sense to reach a decision to abandon their use.

The attempts by the ...

To the Editor: The article by Ezekowitz et al. on warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation (Nov. 12 issue)¹ is another example of discrimination against women in health issues. Only men were enrolled in this ...

To the Editor: Thromboembolism is a frequent and serious complication of valvular heart disease, particularly mitral stenosis¹,². Recently, sensitive molecular markers for assessing thrombotic and fibrinolytic states have been identified³. We measured ...

To the Editor: I wish to comment on the dose of beclomethasone used by Kerstjens et al. (Nov. 12 issue)¹ in their study of bronchodilator therapy with and without inhaled corticosteroids for chronic obstructive pulmonary disease (COPD). Readers should be ...

To the Editor: The article by Canellos et al. (Nov. 19 issue)¹ makes an important contribution to the longstanding controversy²,³ about the optimal drug regimen for advanced Hodgkin's disease. On the basis of their investigation, the authors conclude ...

To the Editor: The report by Wiggins and colleagues (Nov. 12 issue)¹ provides valuable information on the psychological outcomes of persons undergoing presymptomatic DNA testing for Huntington's disease. One important issue is not addressed, presumably ...

To the Editor: Malaria should be considered in the differential diagnosis of fever in any patient returning from an area where the disease is endemic¹. During the Vietnam War, there were more than 14,000 cases of imported malaria among U.S. military ...

To the Editor: The staggering number of antibiotics to choose from strains the memory. Physicians often latch onto a memorable trade name in preference to a generic name. Residents and medical students seem most likely to correlate a trade name with a ...

Investigative dermatology encompasses many quite different areas, a number of which have developed in new directions, and at markedly different and erratic rates, over the past decade. The result has been a sort of joyful chaos for those working in these ...

The term “eczema” is often misused and misunderstood, but Professor Marks and his coauthors tackle the subject directly and thoroughly. The contributors are for the most part leading researchers on their specific topics. Although the chapters have been ...

In Sun-Damaged Skin the author has condensed information about an extensive subject into a small book that can easily be read in a short time. The most pleasing aspect of the book is the beautiful presentation, including the photographs, photomicrographs, ...

Many books are good. Some books are unique. Few medical books are fun to read. Advanced Dermatologic Diagnosis is all three.

The book is good (in fact, it is excellent). It presents a wealth of information in a stimulating style. Helpful diagnostic clues ...

This book is a gallery of normal human cutaneous microanatomy. It consists of 180 color or black-and-white photographic plates organized into chapters that correspond to the various components of the skin: epidermis, dermis, blood vessels, sensory organs, ...

The scope of this book is formidable; it covers not only a wide range of inflammatory dermatoses but also benign and malignant cutaneous neoplasms, for a total of 90 different diseases. As compared with other textbooks of dermatopathology, it is unique in ...

The sharp and crisp black-and-white micrographs are an outstanding feature of this book; there is also an excellent series of color photographs of cytologic specimens. The bibliography is abundant and up to date. The fact that this book was written by ...

As we witnessed the starvation, disease, and dying in Somalia, it was surely difficult to remember that Somalia was the site of the greatest triumph of 20th-century international public health. There, in October 1977, Ali Maow Maalin, a 23-year-old cook ...

During his first visit to an underdeveloped country, a prominent psychologist spent hours quietly observing, and being observed by, a skeletal infant who at eight months of age weighed less than when she was born. Her slow, shallow breathing was almost ...

The Four Horsemen of the Apocalypse -- War, Famine, Pestilence, and Death -- ride the arid plains of Somalia. Despite the protection offered by modern chemoprophylaxis, immunization, and preventive medicine, military personnel safeguarding food delivery ...