Since the completion of the large, randomized, placebo-controlled trials of thrombolytic therapy, reperfusion therapy for acute myocardial infarction has become the standard of care¹–⁷. However, the drawbacks of this therapy include failure to achieve ...

In 1980 DeWood et al.¹ showed that acute transmural myocardial infarction is usually associated with total coronary occlusion due to an intraluminal coronary thrombus superimposed on an atherosclerotic lesion. Over the past decade the efficacy of ...

Although early intravenous thrombolytic therapy reduces mortality and infarct size in patients with acute myocardial infarctions,¹–⁶ it has several potential limitations. Many patients have contraindications to thrombolytic therapy,⁷ and in approximately ...

Intrauterine growth retardation is an important cause of perinatal mortality and morbidity,¹,² and infants with this disorder have a greater risk of handicaps in later childhood². At present, no intrauterine therapy is available for affected fetuses: ...

Non-insulin-dependent diabetes mellitus (NIDDM) is a heterogeneous disorder of glucose homeostasis characterized by defects in the secretion and action of insulin. The familial aggregation of NIDDM and high concordance rate in identical twins indicate the ...

Hyperkalemia has been reported in 16 to 21 percent of patients hospitalized with the acquired immunodeficiency syndrome (AIDS)¹–³. Although renal failure often accompanies hyperkalemia,¹,² AIDS is associated with other abnormalities that impair renal ...

Figure 1. Emergency Coronary-Artery Angioplasty for Cardiogenic Shock Complicating Acute Myocardial Infarction.

Coronary-artery angioplasty was performed in a 45-year-old man who presented with two hours of crushing retrosternal chest pain and hypotension ...

Magnetic resonance imaging (MRI) has become an essential tool for the diagnosis of central nervous system disorders and is used increasingly for the evaluation of a variety of diseases in other organ systems. The interpretation of magnetic resonance ...

Presentation of Case

A 67-year-old man was admitted to the hospital because of ataxia and the recent onset of atrial fibrillation.

The patient had been well until one month earlier, when he began to experience sweats without documented fever. During the ...

During the past 10 to 15 years, pathological and arteriographic studies have shown that Q-wave myocardial infarction is usually caused by an occlusive coronary arterial thrombus. Investigations have also shown that thrombolytic therapy can restore ...

Prenatal events have important implications for health in childhood and adult life. Newborns whose birth weights are low for their gestational age are at much greater risk for a wide range of problems: in the perinatal period, stillbirth, asphyxia during ...

Non-insulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and abnormal beta-cell function. The underlying cause is probably the combined effects of a Western lifestyle (corpulence and sedentary behavior) and as-yet-...

To the Editor: Dr. Angell's editorial (June 18 issue)¹ on the breast-implant controversy refreshingly highlights the forgotten half of the risk-benefit ratio: efficacy. As Dr. Kessler points out in the same issue,² the 1976 Medical Device Amendments to ...

To the Editor: The recent reports by Stiell¹ and Brown² and their colleagues (Oct. 8 issue) on the use of high-dose epinephrine for cardiac arrest in adults show an apparent lack of benefit. Stiell et al. found that some patients receiving high doses of ...

To the Editor: Drickamer and Lachs (April 2 issue)¹ thoughtfully discuss the ethics of telling patients with Alzheimer's disease their diagnosis, but they do not tell of the agony of knowing, nor of its possible consequences.

As a doctor who has suffered ...

To the Editor: I wish to comment on an interesting new phenomenon, the extraordinary acceleration in the cost of continuing education for those engaged in managed care. After a 40-year medical career, 31 in internal medicine, 6 in medical education, and ...

To the Editor: The ability to achieve pregnancy after egg donation represents an important recent medical advance, not only because of its scientific merit, but also because of the way in which it benefits society. A woman with ovarian failure or known ...

The year 1995 will mark the centennial of Roentgen's discovery of the x-ray, a notable event prompting renewed interest in the history of radiology. Few among us, even senior radiologists, have more than a cursory knowledge of this history. Until now, ...

Turn the clock backward 40 years, and think for a moment of the changes that have occurred in diagnostic imaging. In the fifth decade of the century, the field did not even include digital-subtraction angiography, diagnostic ultrasonography, computed ...

This excellent textbook provides a review of endoluminal contrast radiography of the small bowel. The authors of the 16 chapters are highly qualified to write the book; all are recognized authorities in the field, with extensive experience in contrast ...

The aim of this book is to provide a radiologic-anatomical work that is both didactic and concise. “The work is meant to be simple and practical,” the preface states. “It is meant to be widely referred to by all those in the medical fraternity, both ...

The first edition of this book was published in 1987, at a time when nonneurologic applications of MRI were in their infancy. Five years later, the editors, all members of the faculty of the University of California, San Francisco, have enlarged the ...

This is the second edition of a well-respected textbook, the first edition of which was published in 1986. Dr. Hunt has again put together a distinguished group of contributors who are experts in female infertility surgery. Hunt answers the question about ...

Head and Neck Oncology is designed to be a comprehensive, multidisciplinary reference for the physician who is inexperienced in dealing with head and neck tumors. The quality of the short, concise chapters is extremely variable, depending on the author, ...

The Role of Interleukin-1 in Disease Review Article, N Engl J Med 1993:328;106-113.. On page 109, in the right-hand column, the sentence beginning on line 9 of the text should have stated that 16 percent of those treated with a continuous infusion of ...