TESTING hospital patients for human immunodeficiency virus (HIV) infection can identify those with early infection in a setting where there is ready access to appropriate counseling, clinical referral, evaluation, and therapy.^{1 2 3 4} Knowledge of such ...

HEPATITIS A is a disease with a worldwide distribution; although rarely fatal, it is a common cause of morbidity in developed and developing nations. The annual cost of cases of hepatitis A in the United States is estimated to be over $200 million.¹ ...

A THIRD heart sound or S₃ gallop (previously known as a ventricular or protodiastolic gallop) in an adult is usually interpreted as a sign of ventricular dysfunction. Its detection depends on the skill of the examiner and varies widely even among ...

CARDIAC tamponade, a serious manifestation of pericardial effusion, has a broad range of clinical and hemodynamic features. The hemodynamic findings may vary from normal intracardiac pressures and cardiac output in mild cardiac tamponade to a state ...

EACH year more than 29,000 Americans kill themselves, making suicide the eighth leading cause of death in the nation.^{1 , 2} Despite the widespread adoption of telephone crisis lines,³ school-based intervention programs,^{4 5 6} and newer varieties of ...

Adjuvant Therapy of Breast Cancer

The demonstration that adjuvant systemic therapy (i.e., systemic therapy given at the time of primary local treatment in the absence of demonstrated metastases) can prolong the disease-free interval and improve overall ...

Presentation of Case

A 34-year-old woman was admitted to the hospital because of low-back and flank pain, with oliguria.

The patient was well until seven years earlier, when severe abdominal pain developed, and a laparotomy performed at another hospital ...

Now in its second decade, the human immunodeficiency virus (HIV) epidemic continues to escalate relentlessly. Approximately 1 million people in the United States are infected with HIV, and nearly a quarter of a million have been given diagnoses of the ...

The first effective control measures for the prevention of enterically transmitted viral hepatitis resulted from research conducted during World War II. In 1945, Neefe et al.¹ demonstrated that infectious virus could be transmitted by contaminated ...

Suicide is the intentional taking of one's own life. It is not the unhappy result of the actions of a daredevil, nor is it the consequence of an unconscious desire to die. Because suicide is the eighth most frequent cause of death, it is fitting that it ...

Nothing in medicine, or in life for that matter, always works. This seemingly incontrovertible statement often appears to be forgotten where preventive measures are concerned. Because of its paramount importance, the epidemic of acquired immunodeficiency ...

To the Editor: The study by Fowler et al. (March 5 issue)¹ on the outcome of congenital cytomegalovirus (CMV) infection according to whether the infants' mothers had primary or recurrent disease during pregnancy provides valuable data for use in ...

To the Editor: The report by Polish et al. (March 12 issue)¹ of a hospital-based outbreak of hepatitis B in 26 patients who had undergone capillary blood sampling by finger stick with a spring-loaded lancet device strikingly demonstrates how seemingly ...

To the Editor: Cyclosporine has been used in patients with severe refractory inflammatory bowel disease^{1 , 2} without an increase in infectious complications.³ We report a case of Pneumocystis carinii pneumonia that occurred in a man with ulcerative ...

To the Editor: Like Drs. Martinez and Marr (March 12 issue),¹ we would welcome efficacious, safe, and inexpensive oral agents to augment and perhaps replace parenteral pentavalent antimonial compounds for treating leishmaniasis. In their study of the ...

To the Editor: In their excellent review article on Hodgkin's disease (March 5 issue),¹ Urba and Longo recommend that radiotherapy should be delivered only by an experienced radiation oncologist because the "treatment outcome may vary in relation to the ...

To the Editor: Atherosclerotic plaques and thrombi in the aorta are a common finding at autopsy,¹ but can also be detected during life by transesophageal echocardiography.^{2 3 4 5} A significant association has been described between arterial embolism and ...

To the Editor: In the review of the Guillain—Barré syndrome by Dr. Ropper (April 23 issue),* we believe there is an error in the description of conduction blocks. In the typical conduction block, the amplitude on distal stimulation should be greater than ...

To the Editor: Robert Wachter's Sounding Board article (Jan. 9 issue)* on activism related to the acquired immunodeficiency syndrome (AIDS) appropriately highlights the tremendous contributions of AIDS activists to the fight against AIDS. However, this ...

To the Editor: We want to report on the possible effect of coverage of suicides in the print media on the number of suicides committed in the subway system in Vienna. Since its opening in 1978, the Viennese subway has been used as a method of attempting ...

The diagnosis and classification of lymphoproliferative disorders continue to present a formidable challenge to surgical pathologists. The current diagnostic armamentarium must include not only the gold standard of a perfect histologic section, but also ...

This succinct textbook of dermatopathology is written in a direct and informal style, with occasional humor, and much of the writing appears to reflect the author's personal experience. The 18 chapters reveal a somewhat unorthodox sequence and grouping of ...

Ashley Robins is a senior lecturer in clinical pharmacology at the University of Cape Town Medical School in South Africa. From the variety of aspects of human pigmentation that he covers, it is obvious that he is intensely interested in this subject. ...

REGISTRY OF PATIENTS WITH CRIGLER—NAJJAR SYNDROME TYPE I

Crigler—Najjar syndrome is a rare disease characterized by a severe unconjugated hyperbilirubinemia. The management of these patients includes either lifelong phototherapy or liver transplantation. ...