IN 1907, George Whipple reported a "hitherto undescribed disease" in a 36-year-old medical missionary with migratory polyarthritis, cough, diarrhea, malabsorption, weight loss, and mesenteric lymphadenopathy.¹ He named this disease "intestinal ...

THE destruction of the pancreatic beta cells that occurs in patients with insulin-dependent diabetes mellitus is autoimmune in nature, but the cause of the autoimmune process is not known. Several recessive genes map the risk of diabetes,¹ but the ...

PHARMACOLOGIC inhibition of preterm uterine activity with beta-adrenergic agonists has been used extensively in the past 20 years to arrest premature labor.¹ It has been assumed that the use of these agents reduces perinatal mortality and the frequency of ...

ATRIOVENTRICULAR nodal reentrant tachycardia (AVNRT) is the most common form of paroxysmal supraventricular tachycardia.¹ The reentrant circuit contains, as its critical components, a "fast" atrioventricular nodal pathway connecting the atrium to the His ...

BREAST cancer is a major public health problem of great interest and importance to physicians in a variety of specialties. Since this topic was last reviewed in the Journal,¹ the incidence of the disease has increased dramatically, heightening concern ...

THE wasting syndrome is one of the most devastating aspects of the acquired immunodeficiency syndrome (AIDS). Until therapies are developed that eradicate the human immunodeficiency virus (HIV) or halt its replication, wasting will be a major cause of ...

Presentation of Case

A 68-year-old man was transferred to this hospital because of an acute myocardial infarct with fever, pulmonary edema, and oliguria.

The patient was in stable health until two weeks earlier, when he began to experience fatigue. One ...

The general public often wonders why academic medicine focuses so much of its energy on rare diseases when many much more common disorders cry out for attention. Whipple's disease is an excellent example. Dobbins points out in his rigorously documented ...

Insulin-dependent diabetes mellitus (IDDM) remains an enigmatic disease despite a number of spectacular research discoveries during the past two decades that relate to its underlying genetics and pathogenesis.¹ Many investigators are convinced that an ...

The infant mortality rate has become a benchmark in measuring progress toward U.S. health objectives. Approximately 40,000 infants die in the United States each year before reaching their first birthday. The overwhelming risk factor for infant mortality ...

Some time ago it came to the attention of our Pharmacy and Therapeutics Committee that some faculty members were sponsoring drug fairs — events for which pharmaceutical manufacturers are invited to come into the medical school, put up displays, and hawk ...

To the Editor: We write as concerned respiratory physicians to offer our views of the ways in which inhaled β₂-adrenergic agonists should be used in the care of patients with asthma in the light of recent reports about their effects on the severity of ...

To the Editor: López-Zeno et al. (Feb. 13 issue)¹ address a problem of great concern — the alarmingly high rate of cesarean section in this country. However, their perspective on the cause of this problem and their proposed solution disturbs us even ...

To the Editor: We disagree with the conclusion reached by Hamilton et al. (Feb. 13 issue)¹ that one may consider delaying zidovudine therapy in patients with human immunodeficiency virus (HIV) infection who have CD4+ counts between 200 and 500 per cubic ...

To the Editor: In "How Sure is Sure Enough?" (March 5 issue),* a 40-year-old woman is described as if she had been admitted to the hospital because of sharp left-sided chest pain before any diagnostic efforts were undertaken in the physician's office or ...

To the Editor: Over 100 cases of cocaine-associated myocardial infarction have been reported since it was first described in 1982.^{1 , 2} Cocaine-induced myocardial ischemia results from coronary vasoconstriction, enhanced platelet aggregation, increased ...

To the Editor: The French Study Group on Selective Decontamination of the Digestive Tract are to be congratulated on completing their multicenter double-blind study (Feb. 27 issue).¹ However, we believe their conclusions about the effect of selective ...

To the Editor: I commend Madoff et al. for their thoughtful review on fecal incontinence (April 9 issue),¹ but I would like to add two points from a pediatric perspective relating to the fact that many children with fecal incontinence suffer from chronic ...

To the Editor: Recent guidelines^{1 2 3 4} make it clear that the pharmaceutical industry will remain heavily involved in medical education and continuing medical education. We physician-educators are losing the battle for the hearts and minds of our house ...

Medical oncology differs from other subspecialties of internal medicine in that it is not based on a particular organ system. There is no normal physiologic state with its accompanying physical findings and laboratory studies on which to build a framework ...

Mammographic abnormalities constitute a new challenge for physicians. Surgeons who have learned to work with radiation oncologists and chemotherapists in the treatment of invasive breast cancer now find that they need new partners. Close collaboration ...

This monograph relates the pathogenesis and treatment of prostate cancer to molecular biology. Investigators attempt to answer several questions. Which men are at risk for prostate cancer? Which subclinical prostate cancers will become clinically ...

Whereas most textbooks of pediatric oncology tend to present treatment philosophies based on protocols of a specific national cancer group, this book successfully struggles to present a balanced view of international therapeutic rationales, while ...

Just as primary bone tumors are uncommon, so is the publication of a textbook that concisely reviews their epidemiology, histopathology, radiology, treatment, and prognosis. Most books in this field concentrate on one or two of these facts, but Dr. Huvos ...

Radiation oncology is a rapidly expanding field of medicine, as the result of both exciting new technological advances and major developments in the basic understanding and applications of radiobiology. Over half of all patients in whom cancer is ...

Biomedical Science

The Airway Epithelium: Physiology, pathophysiology, and pharmacology. (Lung Biology in Health and Disease. Vol. 55.) Edited by Stephen G. Farmer and Douglas W.P. Hay. 677 pp., illustrated. New York, Marcel Dekker, 1992. $165.

Anaerobic ...

BONE MARROW TRANSPLANTATION IN THALASSEMIA

The 2nd international symposium will be held in Pesaro, Italy, Sept. 24–27.

Contact Agenzia di Relazioni Pubbliche, C.so XI Settembre, 129, 61100 Pesaro, Italy; or call (39) 721 32494.

PROBLEMS IN DEVELOPING ...

Induction of Labor as Compared with Serial Antenatal Monitoring in Post-term Pregnancy — A Randomized Controlled Trial (June 11, 1992;326:1587–92). On page 1590, in the left-hand column, the P values given in the 8th and 11th lines should have been 0.023 ...