LYME disease, caused by Borrelia burgdorferi, is transmitted by the deer tick, Ixodes dammini, in the northeastern United States.¹ In areas in which the disease is endemic, deer-tick bites are common and can cause tremendous anxiety, but there is ...

THE hepatorenal syndrome, a common complication of chronic and acute liver failure, is characterized in its most extreme form by intense renal vasoconstriction that mediates a potentially reversible form of acute renal failure.^{1 2 3} The cause of the renal ...

ISOLATED thrombocytopenia associated with human immunodeficiency virus (HIV) infection has been well described.^{1 2 3} Numerous studies have identified increased amounts of platelet-associated IgG, IgM, C3,^{4 5 6} and immune complexes^{4 , 7} on autologous ...

THE prognosis for patients with cystic fibrosis has improved dramatically in the past two decades, with median survival increasing from 10.6 years in 1966 to 28.0 years in 1989.¹ Several factors have been identified that seem to be associated with ...

THE recruitment of neutrophils to sites of inflammation is initiated by the local production of bacteria-derived attractants, inflammatory cytokines, and other host-derived factors. These factors induce the rolling of neutrophils on the blood-vessel wall,^...

A young man presented with two common manifestations of early Lyme disease: the skin lesion on his arm, termed erythema chronicum migrans (Panel A), and Bell's palsy, causing left facial droop (Panel B).

ONE of the most important medical developments in the 20th century has been the control of once common childhood infectious diseases by the administration of highly effective vaccines. In the United States, the reported number of cases of diphtheria, ...

Presentation of Case

A 54-year-old man was admitted to the hospital because of lymphoma and fever of unknown origin.

The patient was in stable health until four years earlier, when cervical and axillary lymphadenopathy developed, with slight peripheral ...

Patients with liver disease often have a unique form of renal failure for which a specific cause or causes cannot be identified. This condition has been given many names, including functional renal failure and the renal failure of cirrhosis, but it is ...

Thrombocytopenia is a common complication of infection with the human immunodeficiency virus (HIV), but it is not related to the presence or absence of the acquired immunodeficiency syndrome (AIDS), and patients with HIV-related thrombocytopenia do not ...

To the Editor: Sampson et al. (Aug. 6 issue)¹ suggest that the frequency of fatal and near-fatal anaphylactic reactions to food has risen over the past several years. They mention that the increased use of protein additives in food could cause such an ...

To the Editor: The article by Janssen et al. (Aug. 13 issue)¹ is a welcome addition to the growing debate over the counseling and testing of hospitalized patients for the human immunodeficiency virus (HIV). The authors, however, make two assumptions that ...

To the Editor: During 1991, an outbreak of multidrug-resistant tuberculosis, defined as tuberculosis resistant at least to isoniazid, rifampin, ethambutol, and streptomycin, occurred at our institution.^{1 2 3} Tuberculous pericarditis developed in two ...

To the Editor: A male health care worker from New York City who is positive for HIV was recently referred to our facility for management of suspected drug-resistant Mycobacterium tuberculosis disease. ¹ Disseminated tuberculosis had been diagnosed ...

To the Editor: The final analysis of the data from the first Cardiac Arrhythmia Suppression Trial (CAST-I) (March 21, 1991, issue)¹ did not address the problem of treatment with calcium-channel blockers in addition to antiarrhythmic drugs, although 39 ...

To the Editor: The study by Folland et al. (Aug. 13 issue)* reporting on the meaning of third heart sounds in valvular heart disease cannot go unchallenged. The poor design of the study undermines the importance of its conclusions.

The assumption that ...

To the Editor: In the recent Clinical Problem-Solving article by Thibault (Sept. 3 issue),¹ the expert clinician is told that an endomyocardial biopsy revealed extensive areas of apple-green fluorescence when stained with Congo red. In fact, the amyloid—...

In their introduction the editors of this collection offer this judgment:

It is remarkable that we know so little about the roots of medical journalism, about the development of the typical form and format of the journal, about editorial practices, about ...

James Harvey Young, the author of American Health Quackery and emeritus professor of history at Emory University, is a living legend for his graceful and lucid chronicling of health quackery. His continuing efforts to educate government regulators and the ...

Research fraud is not a new phenomenon. Historians have identified abundant evidence of scientific chicanery over the centuries. But is it more frequent today than in the past? Are today's highly publicized examples simply the result of the actions of ...

Until recently, biomedical researchers have not faced conflicts of interest of sufficient magnitude to warrant the declaration of a problem, either by them or by outsiders, as Petersdorf states in the introduction to this book. It follows that those ...

In this small book the author reports on her survey of recruitments and departures of academic physicians in six diverse medical institutions. She views her findings in the context of a similar study she performed a few years earlier in faculties of arts ...

Animals and Disease is an interesting book that will have special appeal to veterinarians, epidemiologists, and teachers of preventive medicine and public health. The author begins with the concern of humans with the health of animals in the ancient ...

CLINICAL ASPECTS OF HIV INFECTION

The "3rd Symposium" will be held in Montreal, Jan. 28 and 29.

Contact Dr. Pierre Côté, 1001 St-Denis St., Montreal, QC H2X 3H9, Canada; or call (514)281–4138.

CREIGHTON UNIVERSITY

The following will be held in Omaha, ...