INJECTION-DRUG users account for an increasing proportion of the cases of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS) in North America, Europe, and certain regions of the developing world.^{1 2 3 4} Given ...

IN the United States, women account for an increasing number and percentage of the cases of the acquired immunodeficiency syndrome (AIDS) among adults.¹ Data through 1991 indicate that 84 percent of the women with AIDS were of reproductive age (15 to 44 ...

POST-TRANSPLANTATION lymphoproliferative disease (PTLD), either polyclonal or monoclonal, complicates the clinical course of 1 to 10 percent of organ-transplant recipients.^{1 2 3} Immunohistochemical studies have demonstrated that the lymphoid cells within ...

THE pulmonary-capillary wedge pressure (PCWP) is an important indicator of cardiac function and intravascular and pulmonary venous volume. Clinical and radiographic methods of detecting congestive heart failure are insensitive to increases in the PCWP,^{1 ,} ...

AMYOTROPHIC lateral sclerosis is a neurodegenerative disease of unknown cause^{1 2 3 4} that compromises motor neurons, produces progressive weakness and paralysis, and culminates in respiratory failure and death. Studies attempting to implicate viruses, ...

THE process of plasminogen activation is considered a critical component of diverse biologic systems in humans. This reaction, which is catalyzed in vivo by tissue-type and urokinase-type plasminogen activators, results in the conversion of plasminogen to ...

Lesions of acute bacterial endocarditis are shown in a 40-year-old male intravenous drug user with sudden fever, severe crampy, left-sided abdominal pain, nausea, and vomiting. A contrast-enhanced abdominal CT scan demonstrates bilateral wedge-shaped low-...

DESPITE the decline in rates of mortality due to heart disease during the past two decades, cardiovascular disease remains the most frequent single cause of death among persons over 65 years of age.^{1 2 3} It also accounts for a major and growing proportion ...

Presentation of Case

A 70-year-old man was admitted to the hospital because of coronary artery disease and congestive heart failure.

There was a long history of hypertension with exertional dyspnea of 10 years' duration and angina pectoris with increasing ...

IN the nearly 30 years since the discovery of the Epstein–Barr virus (EBV) in a Ugandan child with Burkitt's lymphoma, the virus has been associated with an array of disorders, both benign and malignant. Their variety is at first confusing, but cellular ...

Amyotrophic lateral sclerosis has become one of the prime targets of modern neurologic research. With Alzheimer's disease and Parkinson's disease, it is one of the so-called degenerative diseases of the aging nervous system. "Degenerative" means there is ...

After appearing for 180 years only in print, the Journal has ventured into a new medium — television. On November 1, Lifetime Medical Television introduced a weekly Sunday program, This Week in the New England Journal of Medicine, that is based on ...

To the Editor: In the first part of a three-part series, Harris et al. (July 30 issue)* provided an excellent review of the risk factors for breast cancer, the disease burden, and the methods of screening for breast cancer. Tragically, many women die ...

To the Editor: In the Canadian study of ritodrine (July 30 issue),¹ no mention is made of the power of the study to detect meaningful differences. I have calculated its statistical power for the major outcome variables and have found there to be serious ...

To the Editor: Hamm and colleagues (July 16 issue)¹ demonstrate the value of troponin T determinations in patients with unstable angina but understate their value in the differential diagnosis of patients with ischemic heart disease. In a preliminary ...

To the Editor: I enjoyed reading the excellent article by Benjamin et al. (Aug. 6 issue)¹ on the relation of mitral annular calcification (MAC) to the occurrence of stroke in an elderly cohort of the Framingham Study. However, I would like to raise some ...

To the Editor: Delayed sleep phase syndrome (DSPS) is a disorder of the timing of sleep caused by an abnormally delayed circadian clock and manifested by a persistent inability to fall asleep until late in the night and great difficulty in arising until ...

"What do we want to be when we grow up? " seems to be Dr. Pearlman's question to psychiatry. This discipline has undergone periodic swings from the biologic to the psychosocial and back throughout its history. In the early 19th century, "moral treatment," ...

The scientific basis of psychiatry is not easy to define and is constantly evolving, but it includes a great deal of neurobiology, pharmacology, psychology, genetics, and epidemiology. Thus, a book with a title like this one is an ambitious affair ...

Patients with psychosomatic disorders have fascinated, irritated, and stymied physicians since antiquity because of the profession's inability to make full sense of them. Psychiatrists, who are perhaps in the best position to conceptualize these disorders,...

The Radcliffe Biography Series of books on extraordinary women has added another volume, this one by Robert Coles. The author's personal communications and discussions with Anna Freud from the 1950s through the 1970s are used to delineate the facets of ...

This volume on adolescence is part of a series edited by Greenspan and Pollock that is intended to compile and organize what psychoanalysts have learned about the successive stages of human development. The series is a revised and expanded version of ...

This book, with chapters by the editors and by 15 contributing psychoanalysts, discusses technical aspects of the psychoanalytic treatment of male and female homosexuals. Its organizing thesis, derived from theories of Sandor Rado, Irving Bieber, Charles ...

Medicine

AIDS and Other Manifestations of HIV Infection. Second edition. Edited by Gary P. Wormser. 715 pp., illustrated. New York, Raven Press, 1992. $130. ISBN 0–88167–881–3.

AIDS Clinical Review 1992. Edited by Paul Volberding and Mark A. Jacobson. 340 ...

QUALITY MANAGEMENT FOR THE MEDICAL AND DENTAL PROFESSIONAL

The course will be offered as follows: Winter Park, Fla., Jan. 14 and 15, March 11 and 12; Princeton, N.J., Feb. 18 and 19.

Contact Philip Crosby Assoc., 3260 University Blvd., P.O. Box 6006, ...

Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions (September 3, 1992;327:685–91). On page 689, in the right-hand column, the sentence beginning on line 12 should ...

Effect of the Gulf War on Infant and Child Mortality in Iraq (September 24, 1992;327;931–6). Dr. Tim Coté's institutional affiliation was given as the National Institutes of Health, implying support of the study by the U.S. government. Actually, Dr. Coté ...

The Heart in Hypertension (October 1, 1992;327:998–1008). On page 998, in the right-hand column, line 8, and on page 999, in the right-hand column, six lines from the bottom, the phrase "coronary heart failure" should have read "congestive heart failure." ...