DESPITE improvements in immunosuppressive therapy after transplantation, acute graft-versus-host disease (GVHD), mediated by host-reactive donor T cells in the bone marrow inoculum, remains a major cause of morbidity and mortality after allogeneic bone ...

THE role of thoracic radiotherapy in the management of limited small-cell lung cancer remains controversial. Most investigators agree that it decreases the risk of thoracic recurrence significantly, but no agreement has been reached concerning its ...

BACILLARY angiomatosis is a newly recognized infectious disease, primarily affecting immunocompromised patients, most commonly those infected with the human immunodeficiency virus (HIV). The most common cutaneous lesions are angiomatous, tender papules or ...

ALGLUCERASE (Ceredase), "the world's most expensive drug,"¹ provides effective enzyme-replacement therapy for Gaucher's disease. However, the high cost of the medication has placed it out of reach for many patients. In the study that validated its ...

THE risk of hip fractures and other nonvertebral fractures increases in the elderly, reaching near-epidemic levels in many developed countries. Although many factors contribute to such fractures, the most important causes are a reduction in bone mass and ...

TOXOPLASMOSIS of the central nervous system occurs in 3 to 40 percent of all patients with the acquired immunodeficiency syndrome (AIDS), and it is the most common opportunistic infection to cause encephalitis or focal intracerebral lesions.¹ It is ...

BASAL-CELL and squamous-cell cancers of the skin are the most frequent malignant conditions in the white population. About 600,000 new cases are detected each year in the United States.¹ Fortunately, only a small proportion lead to death. Nonmelanoma ...

A 61-year-old man with a long history of heavy alcohol use went to the emergency room with symptoms of abdominal pain, early satiety, and a 10-lb weight loss. His wife had died seven months earlier, and he had been depressed ever since. He said that he ...

Presentation of Case

An 82-year-old man was admitted to the hospital because of abdominal pain, nausea, and vomiting.

There was a history of a right pulmonary parahilar radiologic density interpreted as atelectasis in the superior segment of the right ...

Alglucerase offers the first real hope of reversing the glycolipid deposition responsible for the painful and sometimes life-threatening complications of Gaucher's disease. Because it is both uniquely promising and remarkably expensive, it poses stark ...

Barbiturates are well known for their capacity to cause death reliably and painlessly and for their efficacy in producing unconsciousness before the administration of other lethal drugs. Barbiturates are used in the execution of prisoners by lethal ...

Health care reform is in the wind. As the nation prepares for a new presidential term, a more equitable and cost-effective health care system is beginning to sound inevitable.¹ But the shape of that system remains a matter of debate. Employer-provided ...

To the Editor: With respect to the article by Dr. Waud on pharmaceutical promotions (July 30 issue),* it is unrealistic in the current economic climate to think that the government is going to pay for my continuing education, and neither will the ...

To the Editor: I found it ironic that Dr. Douglas Waud's impassioned Sounding Board article (July 30 issue),* which strongly opposed the acceptance by physicians of gifts from pharmaceutical companies, either direct or indirect (e.g., a subsidy for ...

To the Editor: Shenton et al. (Aug. 27 issue)¹ report a reduction in limbic-tissue volume in their sample of patients with schizophrenia, but they found neither reduced global tissue nor enlarged ventricles. Using automated segmentation, others have ...

To the Editor: Vanderwinden et al. (Aug. 20 issue)¹ ascribe infantile hypertrophic pyloric stenosis to a deficiency of nitric oxide synthase in enteric nerve fibers. Although this is an attractive hypothesis, it is poorly supported by the results ...

To the Editor: Although the importance of thrombus in acute coronary syndromes is clear, the relative contribution of thrombus and plaque to an acute occlusion is generally unknown. We describe the use of intracoronary ultrasound imaging to evaluate the ...

This book is based on a series of lectures for Harvard medical students. The fifth edition has been updated to cover recent developments in hematology such as the use of hematopoietic growth factors and molecular descriptions of the hemoglobinopathies. In ...

As suggested by their book's title, Babior and Stossel emphasize the pathophysiology of blood disorders, as is appropriate for a textbook directed to medical students. Information about therapy is generally quite limited and would require supplementation ...

This review of hematology textbooks is not intended to be comprehensive. Instead, we chose for review several books that we thought were best suited for medical students and three textbooks that provide comprehensive coverage of hematology. The first four ...

Overall, we considered Introduction to Hematology to be the best of the introductory textbooks. It has a single author, and therefore a consistent style throughout. The chapters are carefully arranged, and there is little unnecessary duplication of ...

The strengths of this single-author book are the excellent expositions of pathophysiology, highlighted by classic cartoons and diagrams from definitive review articles. The photomicrographs are of high quality and complement the clinical descriptions ...

When it was first published in 1972, Hematology complemented what was then the standard textbook, Wintrobe's Clinical Hematology (Philadelphia: Lea and Febiger, 1967). The fourth edition, published two years ago, became the standard against which other ...

Hoffman's Hematology was judged to be the best of the comprehensive textbooks. We all agree that the book successfully covers both the basic-science underpinnings of hematology and its clinical aspects. The first section offers a primer of molecular and ...

CALL FOR ABSTRACTS

Abstracts are being accepted for the "18th Annual Meeting of the National Sickle Cell Disease Program," to be held in Philadelphia, May 22–25. Deadline for submission is Feb. 1.

Contact Janet Fithian, Comprehensive Sickle Cell Ctr., ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...