CEREBRAL malaria, one of the most severe complications of infection with Plasmodium falciparum, is especially common among young children. Despite therapy with parenteral antimalarial agents and attentive management of complications, the mortality rate is ...

THE introduction of MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) was a seminal event in the treatment of Hodgkin's disease, demonstrating the principles and success of combination chemotherapy when effective drugs are given in a ...

TRADITIONALLY, patients with deep-vein thrombosis have been treated first with intravenous heparin and then with a course of oral anticoagulants for three months.¹ Acenocoumarol or another vitamin K antagonist is usually begun after a few days of heparin ...

THE manifestations of mixed cryoglobulinemia range from mild vasculitis, with the characteristic palpable purpura, arthralgias, and weakness, to severe vasculitis, with involvement of the kidneys, nerves, and brain.^{1 , 2} Serologically, cryoglobulins are ...

The images illustrate renovascular hypertension and renal insufficiency in a 57-year-old woman. Arteriography (Panel A) reveals severe bilateral renal-artery stenoses (arrows). A photograph taken during transaortic bilateral renal-artery endarterectomy (...

UNDER federal law, it is illegal for physicians to receive kickbacks for referrals of Medicare and Medicaid patients. Thirty-six states also have anti-kickback laws of various types that apply to both publicly and privately insured patients. General ...

THERE is growing concern about conflict of interest in medicine in the United States.^{1 2 3 4 5 6} Recent studies have focused on whether physicians' ownership of testing or treatment centers increases the number of tests and services performed.^{7 8 9 10} ...

SINCE ancient times,¹ head injuries have had an almost mysterious quality. Although trauma to the head may cause severe tissue disruption of the scalp, skull, and facial and subcranial structures, the ultimate determinant of survival and functional ...

Presentation of Case

A 48-year-old woman was admitted to the hospital because of increasing dyspnea, choking spells, and inability to cough up secretions.

There was a 20-year history of exertional dyspnea that worsened during the 10 years before ...

Over the millennia that humanity has struggled against malaria, some successes in controlling this scourge have been achieved from time to time through both empirical efforts and rational design. The development in the early 1970s of methods to cultivate ...

Lerner and Watson suggested the term "cryoglobulin" to describe a group of proteins with the common property of precipitating from cooled serum.¹ On the basis of immunochemical studies of cryoprecipitable proteins from 86 patients, Brouet et al.² ...

"Self-referral" is the term used to describe a physician's referral of patients to an outside facility in which he or she has a financial interest but no professional responsibility. This practice has become particularly prevalent in certain parts of the ...

The debate about health care reform is under way, and for that we should all be grateful. There is little question that reform is needed to control costs, ensure access for the tens of millions of Americans who have no health coverage, and improve the ...

To the Editor: Attempts to quantify the results of in situ polymerase chain reaction (PCR) experiments as reported by Bagasra et al. (May 21 issue)¹ run the risk of serious misinterpretation. We have studied the use of this technique for specific ...

To the Editor: Grunfeld and Feingold (July 30 issue)¹ discuss hypermetabolism in patients with AIDS, which is similar to the increased metabolic rate reported in patients with acute infection or trauma and burns.² However, they draw attention to the ...

To the Editor: In their editorial (July 2 issue),¹ Topol and Califf state that the excess risk of cerebral hemorrhage observed with tissue plasminogen activator (t-PA) as compared with streptokinase was more pronounced among elderly patients than among ...

To the Editor: The Sounding Board by Franks et al. (Aug. 6 issue)* was timely. As a general internist for the past 18 years, I have an additional observation regarding strategies to minimize overtreatment. There has been a deterioration in communication ...

To the Editor: The elevated intrapharyngeal pressure produced by playing a wind instrument may occasionally cause hypopharyngeal dilation.¹ We describe an unusual case of a neck abscess presumably due to microperforation of the anterior pharynx during ...

Descartes' problem of the separation of the mind from the body remains as unresolved today as it was in the 17th century. The equation of the mind with biophysics is but one solution. There are those who are thoroughly committed to the idea that the ...

These two small monographs take contrasting approaches to a major scientific and philosophical mystery: How does the human brain work? The size of both these slender volumes contrasts starkly with the vast scale of the question. The title of Dr. Brown's ...

"Wet mind" refers to the burgeoning new field of cognitive neuroscience — the scientific approach that uses neurobiologic tools and techniques (the "wet" part of the term) to understand human cognition (or the mind). Although this approach is not entirely ...

These two books are quite different from one another. Neurons and Networks was designed to be used as a textbook for a sophomore neuroscience course; students who enroll in this course are required to have studied introductory biology and chemistry in ...

Nerve cells and the principles of neuronal circuitry form the core of this book, which is intended to lay the neurobiologic foundations of learning and memory. The authors guide the reader through the development of the nervous system in vertebrates and ...

Wilder Penfield characterized textbooks as "hermetic" and considered them proof that "standardization can halt advance." With information about the nervous system accumulating far more rapidly than Penfield could have envisioned, the goal of this book's ...

CALL FOR ABSTRACTS

Abstracts are being accepted for the "6th International Conference on Behçet's Disease," to be held in Paris, June 30 and July 1. Deadline for submission is March 1.

Contact Dr. Bertrand Wechsler, Pitié-Salpêtrière Hosp., 47/83 Blvd. de ...