BENIGN prostatic hyperplasia is common in aging men. The resulting enlargement of the prostate gland can lead to urethral obstruction and even complete urinary retention.^{1 2 3} The standard treatment is surgical resection of the prostate,⁴ and there has ...

THE number of women infected with the human immunodeficiency virus (HIV) is on the increase worldwide, mainly as a result of heterosexual transmission and intravenous drug abuse, and the majority of infected women are of childbearing age. The World Health ...

ASTHMA is a chronic disease characterized by episodic dyspnea, wheezing, and cough.¹ The prominent functional manifestation of asthma is variable airway obstruction, associated with an exaggerated response to various bronchoconstrictor stimuli.² This ...

INHALED β-adrenergic agonists are the most effective of the available bronchodilator drugs used to treat asthma.¹ However, recent studies have suggested that their regular use in asthma may be associated with increased morbidity and even mortality.^{2 , 3} ...

IMMUNOGLOBULIN molecules are composed of heavy and light chains, which possess highly specific variable regions at their amino termini. The variable regions of heavy and light chains combine to form the unique antigen-recognition site of the ...

PSEUDOHERMAPHRODITISM in men is often caused by genetic deficiencies in the production or action of androgens.^{1 , 2} One form of this condition is a deficiency of steroid 5α-reductase, the enzyme that catalyzes the conversion of testosterone to ...

TO ensure optimal results with a limited donor pool, policy makers have relied on strategies that maximize or reward the development of experience in transplantation. For example, Medicare's reimbursement policy for heart-transplantation procedures ...

Presentation of Case

A 59-year-old woman was admitted to the hospital because of progressive dyspnea.

The patient was in excellent health until four or five years earlier, when she began to experience exertional dyspnea that gradually worsened. Seven ...

After fulfilling its reproductive role, the prostate mostly causes trouble by virtue of its propensity for benign or malignant cellular proliferation in aging men. Benign prostatic hypertrophy causes symptoms of bladder-outlet obstruction in 50 percent of ...

In this issue of the Journal, Kwak et al.¹ give us a progress report concerning their work on the vaccination of patients with lymphoma against their own cancerous cells. In doing so, the authors illustrate a principle with potentially broad therapeutic ...

Given the meticulous attention we pay to objectivity and fairness in the editorial process at the New England Journal of Medicine, it annoyed me to read in a newsmagazine several weeks ago fatuous allegations that medical journals suppress or censor ...

To the Editor: In their Sounding Board article (June 4 issue),¹ Truog et al. convincingly argue that the concept of futility is ill suited to be a rationale for limiting life-sustaining treatments: use of the concept too often obscures the value choices ...

To the Editor: The Clinical Problem-Solving article "Risky Business" and the Sounding Board article "The Problem with Futility" (June 4 issue)^{1 , 2} are contradictory. Drs. Pauker and Kopelman describe a 31-year-old woman with human immunodeficiency virus ...

To the Editor: Among babies with higher birth weights, infant mortality is consistently higher for blacks than whites.^{1 , 2} Schoendorf et al. (June 4 issue)³ report an ostensibly different pattern among infants born to college-educated parents: they ...

To the Editor: In his Medical Progress review article on aphasia, Damasio (Feb. 20 issue)¹ stated that the presence of global aphasia without hemiplegia suggests the possibility of an embolic stroke or brain metastases. Although these are the commonest ...

To the Editor: Kerem et al. report a model for predicting the time to lung transplantation in patients with cystic fibrosis (April 30 issue).¹ Although they acknowledge that they included a limited number of variables, they make no reference to chronic ...

To the Editor: Iglehart points out in his Health Policy Report on the American health care system (June 18 issue)* that "paperless processing of claims" leads to greater efficiency. One must be cautious here, however, because the "efficiency" accrues to ...

To the Editor: An important issue in understanding and preventing the vertical transmission of human immunodeficiency virus type 1 (HIV-1) from a woman to her child is the timing of such transmission. Cases of in utero^{1 , 2} and postpartum (through breast-...

Despite the great importance of blood-pressure measurement, there are often marked discrepancies between values recorded in the clinic and readings taken in nonmedical settings. In addition, the blood pressure of an individual patient can vary greatly ...

As stated in the preface, this book is "intended to provide a state-of-the-art review" of high-resolution electrocardiography. The authors have succeeded admirably in their goal, producing a work of value to anyone interested in the field. High-resolution ...

Exercise and the Heart in Health and Disease is a broad, clinically oriented compendium of current review articles on various aspects of the human cardiovascular response to exercise. It consists of 16 chapters authored or coauthored by 16 contributors; ...

A book on the drug treatment of heart disease can be organized so as to be disease-oriented or drug-oriented. This book is more drug-oriented, with chapters on digoxin, positive inotropic agents, diuretics, angiotensin-converting—enzyme (ACE) inhibitors, ...

This well-written, concise book is an excellent treatise on the behavioral regulation of body sodium homeostasis. It focuses on the behavioral mechanisms mediating sodium hunger — i.e., the salt seeking and salt ingestion that follow sodium deficiency. ...

The first edition of this textbook, published in 1976, was enthusiastically received by medical students, residents, and fellows. Each topic was discussed as part of a pathophysiologic framework that emphasized the big picture and avoided minute detail. ...

According to Confucius, learning without thinking is useless. Textbooks filled with descriptions of disease, pathophysiology, and therapy abound in the medical literature. This book, however, attempts to elucidate the thought processes involved in ...

ST. LOUIS UNIVERSITY SCHOOL OF MEDICINE

The following will be offered: "Pediatric Advanced Cardiac and Trauma Support and Pediatric Advanced Life Support Provider Course" (Nov. 4–6); "Surgical Approaches to the Skull Base" (Nov. 6–8); "2nd Ugo Fisch ...

Nitric Oxide Synthase Activity in Infantile Hypertrophic Pyloric Stenosis (August 20, 1992;327:511–5). On page 511, in the right-hand column of text, the first full sentence should have read, "Finally, immunohistochemical and histochemical studies ...

A Bovine Albumin Peptide as a Possible Trigger of Insulin-Dependent Diabetes Mellitus (July 30. 1992;327:302–7). On page 302, the paragraph at the bottom of the left-hand column, on the sources of support for the study, should have included the ...