PRENATAL diagnosis of inherited disease currently involves sampling cells of fetal origin by amniocentesis in the second trimester of pregnancy, or chorionic-villus sampling in the first trimester, followed by detection of the genetic defect by ...

VIRUSES are an important cause of liver disease in organ-transplant recipients.^{1 , 2} The cloning of the genome for hepatitis C virus (HCV), the principal cause of parenterally transmitted non-A, non-B hepatitis, and the development of a test for ...

AUTOSOMAL dominant polycystic kidney disease can involve multiple organs, including the heart and gastrointestinal tract, as well as the kidneys.^{1 , 2} Affected persons may also have intracranial aneurysms,^{3 4 5 6} a fact that provides additional evidence ...

IN the United States, Chlamydia trachomatis is the most common sexually transmitted pathogen. Several million cases of chlamydial infection occur in the United States every year.¹

C. trachomatis causes substantial morbidity in men, women, and infants. ...

ASTHMA affects over 3 million children in the United States alone, where its prevalence is more than 5 percent.¹ It is the most frequent reason for hospitalization among children, accounting for 11 to 17 percent of all pediatric hospitalizations in major ...

WHEN Iraq invaded Kuwait in August 1990, international trade sanctions were rapidly instituted against Iraq. On January 16, 1991, the war to liberate Kuwait began, and within six weeks Allied forces declared a cease-fire. Civilian revolts against the ...

CANCER of the breast is newly diagnosed in about 180,000 women per year in the United States.¹ In the majority of these cases the cancer presents as a palpable mass, usually found by the patient. With intensive public education about breast cancer and the ...

Presentation of Case

A 72-year-old woman was admitted to the hospital because of orthostatic hypotension with syncopal attacks and proteinuria.

There was a long history of hypertension, which was managed initially with reserpine and thereafter with ...

Detecting fetal disorders in utero has long been a goal of obstetrics. In 1956 sex-chromatin analysis was performed on amniotic-fluid cells to determine fetal sex in pregnancies at risk for X-linked recessive traits. In 1968 the first prenatal diagnosis ...

The association of intracranial aneurysms with autosomal dominant polycystic kidney disease and the 30-day mortality rate of more than 50 percent among patients with aneurysmal rupture¹ have led physicians to consider the value of screening patients with ...

To the Editor: The association of silent ischemia with sudden cardiac death is well described,¹ but has also been disputed.² A causal relation remains to be established. The induction of ventricular arrhythmias by ergonovine-induced silent ischemia ...

To the Editor: Carson and his colleagues report (May 7 issue)* an in-hospital mortality rate of 9.5 percent among patients with pulmonary emboli diagnosed by angiography. On the basis of clinical findings, autopsy results, and death-certificate data, ...

To the Editor: Sellers et al. (May 14 issue)¹ suggest an interaction between a family history of breast cancer and anthropometric factors in postmenopausal women.

A genetic component of body mass has been observed not only among overweight subjects but ...

To the Editor: The most widely accepted criteria for the evaluation of prognosis and for the staging of cutaneous melanoma are histopathologic and clinical.¹ No currently available laboratory tests provide additional prognostic information. Intercellular ...

To the Editor: The review article by Hook and Marra (April 16 issue)¹ on acquired syphilis in adults is informative and comprehensive. However, the recommendation to use a dose of 2.4 million units of penicillin G benzathine intramuscularly for primary, ...

To the Editor: Your editorial (May 21 issue)* implied two things about electronic retrieval of literature that not only are inaccurate but also hinder the information-seeking activities of students and health professionals alike. The frustrating ...

To the Editor:... Advertising in health care is a symptom, not a disease. Health maintenance organizations (HMOs) advertise to attract members and to make money. In his Sounding Board article (May 14 issue),* Brett notes correctly that the Federal Trade ...

To the Editor: A major anticipated effect of the resource-based relative-value scale was to support the primary care physician. In Connecticut, the relative-value scale makes primary care practice for Medicare patients untenable. I base this statement on ...

The 1975 Asilomar conference was the immediate outcome of an extraordinary action taken by a group of molecular biologists closely associated with the development of recombinant DNA technology — namely, the voluntary cessation of all recombinant DNA ...

If, as has been stated, the compleat surgeon never ceases studying anatomy, then Anatomic Exposures in Vascular Surgery will provide him or her with an enormous amount of material presented in clear and attractive fashion. There are helpful narrative ...

The reader's initial impression of Eduardo Zancolli and Elbio Cozzi's Atlas of Surgical Anatomy of the Hand will no doubt reflect the book's somewhat daunting dimensions. This atlas contains almost 750 pages. This is precisely 10 more pages than are ...

This book is sixth in a series on the hand and upper limb. In this series, selected topics in hand surgery are discussed in depth by an internationally known author who acts as the editor of a particular volume. In this case, the topic is pain and its ...

Total joint replacement has become a widely performed and accepted procedure for the treatment of arthritis in joints. There has been an exhaustive accumulation of data over the past 20 years that have supported joint arthroplasty as a standard operation ...

AMYOTROPHIC LATERAL SCLEROSIS: 1992 RESEARCH AND TREATMENT

The course will be held in Houston, Oct. 14–16.

Contact Lila K. Kerner, Baylor Coll. of Med., Office of Com. Educ., 1 Baylor Plaza, Houston, TX 77030; or call (713) 798–6020.

MENTAL ILLNESS

The ...