WITH the increased recognition that nicotine is an addictive drug and that the treatment of nicotine addiction requires a knowledge of individual susceptibility to drug use,¹ it is apparent that the effect of genotype on various aspects of smoking ...

DURING the past 20 years, the survival of grafts 1 year after transplantation of kidneys from cadaveric donors has improved, but long-term survival has not improved at all.¹ In the early 1970s, half the kidneys transplanted from cadaveric donors that ...

THE survival of cadaveric renal allografts is significantly lower in black transplant recipients than in white recipients.^{1 , 2} Before cyclosporine became available, the lower rate of graft survival in blacks was related to poorer HLA matching, ...

THE long-QT syndrome^{1 2 3 4 5} is an inherited disorder associated with recurrent syncope and sudden death from ventricular arrhythmias. We recently identified genetic markers on the short arm of chromosome 11 (11p) that are closely linked to the locus of ...

INSULIN plays a central part in the regulation of carbohydrate, fat, and protein metabolism. Severe insulin resistance, in which treatment with large doses of insulin does not result in adequate metabolic control, is uncommon. Such resistance occurs in ...

A 65-year-old patient underwent the removal of her right breast because of an Infiltrating ductal carcinoma (upper panel). Reconstruction of the breast (lower panel) was accomplished by moving redundant tissues from the lower abdomen to the position of ...

IN 1988, 552,500 residential fires claimed 5065 lives and injured an additional 22,600 people in the United States.¹ Although residential fires make up 23 percent of all fires, they account for 73 percent of fire-related injuries and 80 percent of fire-...

FIFTY years after the advent of antibiotics for clinical use, bacterial meningitis remains an important cause of morbidity and mortality. As such, it represents a unique human infectious disease, because the pathophysiologic effects of disease progression ...

Presentation of Case

A 68-year-old woman was admitted to the hospital because of pleuritic chest pain and increasing dyspnea.

The patient was in stable health until two weeks earlier, when she awoke with right lateral pleuritic chest pain accompanied by a ...

Most people experiment with cigarette smoking in childhood or adolescence. Why do some but not others become regular smokers? Most smokers in the United States say they would like to quit smoking. Why are some successful and others not? A central issue in ...

It is time to expand procedures that will improve the success rates for cadaveric renal allografts, not just for 1 to 2 years but for 10 to 30 years. The number of human kidneys available for transplantation is extremely limited, and there is no ethically ...

In 1957, Jervell and Lange-Nielsen described a family with four children who had congenital deafness, syncope, and prolongation of the QT interval on electrocardiograms.¹ Three of the children died suddenly. Levine and Woodworth described a similar ...

The article on residential fires by Runyan and her colleagues¹ in this issue of the Journal highlights a continuing plague. Residential fires are the leading cause of death due to injury among children in one fifth of all U.S. states.² Among children one ...

To the Editor: The Journal has done a grave disservice to the medical community by featuring two prominent negative papers on anti-endotoxin antibodies (April 23 issue)^{1 , 2} as an editorial and a Sounding Board article, while relegating any rebuttal to a ...

To the Editor: Although the study by Merigan et al. (April 30 issue)¹ demonstrated that the use of ganciclovir as prophylaxis for cytomegalovirus (CMV) infection in heart-transplant recipients was associated with fewer cases of CMV disease than was ...

To the Editor: Giannini et al. (April 16 issue)¹ express appropriate concern about balancing efficacy and toxicity in their report of a trial of methotrexate in children with juvenile rheumatoid arthritis. The absence of toxicity over a six-month period ...

To the Editor: Glomus jugulare tumors, like pheochromocytomas, have been reported to synthesize and secrete norepinephrine and cause hypertension, but these tumors rarely secrete epinephrine.^{1 2 3} The predominance of norepinephrine suggests that ...

To the Editor: Holick et al. (April 30 issue)¹ measured the vitamin D concentration of infant formula and reported values well above those stated on the label. However, their conclusion that infant formula is overfortified is anomalous. Infant-formula ...

To the Editor: The report of a case of salicylate-induced acidosis (May 7 issue)¹ expresses beliefs about methanol and ethylene glycol poisoning that are unwarranted, though possibly widespread. An increase in measured serum osmolality or the osmolar gap ...

Isaacs' professed intent, explicitly set forth in the preface, is to acquaint practicing pathologists, but also pediatric surgeons, radiologists, and pediatricians, with the kind of tumors they may expect to encounter during active hospital service. This ...

Cancer is primarily a disease of older people, with over 50 percent of cancers occurring in those over the age of 65. With the changing demographics of our population and the improved life expectancy of older adults, we can expect to see an increasing ...

Clinical Hematology and Fundamentals of Hemostasis is a practical textbook on the clinical-laboratory approach to problems involving hematology and hemostasis that will be of interest to both students and educators. This second edition contains five ...

This thoroughly readable and informative book sums up the remarkable career of Dr. Sol Sherry. He was an early pioneer in the development of thrombolytic therapy, and for more than 40 years he has contributed in a major way to making today's thrombolytic ...

One can hardly pick up a clinical, pharmacy, general medical, or subspecialty journal these days without encountering a paper on drug toxicity. The literature on adverse drug reactions has expanded dramatically over the past 10 years. Professor Davies and ...

This guide to the design, performance, and interpretation of clinical trials is a massive reference book consisting of 12 sections, 133 chapters, and 1156 pages. Dr. Spilker's aims are ambitious. His target audience includes both neophytes and experienced ...

Neurology and Psychiatry

Behavioral Sciences. (Oklahoma Notes.) Third edition. By Ronald S. Krug and Alvah R. Cass. 324 pp. New York, Springer-Verlag, 1992. $17.95. ISBN 0–387–97782–1.

Brain and Bannister's Clinical Neurology. Seventh edition. Revised by ...

CALL FOR ABSTRACTS

Abstracts are being accepted for the "1st International Congress on MedicalLegal Aspects of Work Injuries (Myocardial Infarction, Orthopaedic Injuries and Hearing Defects)," to be held in Jerusalem, Israel, Feb. 15–18, 1993. Deadline ...

Safety and Cost Effectiveness of High-Osmolality as Compared with Low-Osmolality Contrast Material in Patients Undergoing Cardiac Angiography (February 13, 1992;326:425–30). On page 425, in the right-hand column of the abstract, the sentence that begins ...

Mortality among Infants of Black as Compared with White College-Educated Parents (June 4, 1992;326:1522–6). On page 1524, in Table 2, under the heading "Maternal Characteristic," the 95 percent confidence interval for the multiparas 20 to 24 years old ...

Endoscopic Sclerotherapy as Compared with Endoscopic Ligation for Bleeding Esophageal Varices (June 4, 1992;326:1527–32). On page 1527, in the right-hand column of the abstract, the fourth line of the last paragraph should have begun, "by endoscopic ...