THE clinical trials that have demonstrated the efficacy of thrombolytic therapy in reducing mortality from acute myocardial infarction^{1 2 3 4} have also consistently shown that thrombolytic treatment does not impose an excess risk of stroke. The favorable ...

PHYSICIANS must often decide whether to administer thrombolytic therapy to older patients who present with signs and symptoms of an acute myocardial infarction. Although some authorities believe that age should not be a contraindication to treatment with ...

THE observation that various human cancers frequently lose blood-group A and B determinants was originally made by Masamune and associates in immunochemical studies^{1 , 2} and by Davidsohn and associates in studies of immunofluorescence reactions and ...

MITOCHONDRIAL oxidation of fatty acids provides the chief source of energy during prolonged fasting as well as for cardiac muscle and skeletal muscle during exercise. In the past decade, 10 genetic defects of this pathway have been recognized in infants ...

THE importance of the normal metabolism of long-chain fatty acids has been emphasized by the increasing number of reports of the association of defects in this pathway with serious and even fatal illness.^{1 , 2} Surprisingly, obvious clinical symptoms are ...

FOUR colony-stimulating factors influence the survival, proliferation, differentiation, and functional activation of myeloid hematopoietic cells: macrophage colony-stimulating factor (M-CSF), granulocyte colony-stimulating factor (G-CSF), ...

A 56-year-old obese white woman with a history of hypertension, diabetes mellitus, and lower-extremity deep venous thrombosis presented to the emergency room after experiencing sudden dizziness, diaphoresis, left-arm pain, and near syncope at work. She ...

Presentation of Case

A 20-year-old man was admitted to the hospital because of increasing abdominal pain.

The patient was well until three years earlier, when an upper gastrointestinal series, performed elsewhere, showed two gastric ulcers; cimetidine was ...

The elderly, particularly the very elderly, are the fastest-growing segment of the U.S. population.¹ They account for over 60 percent of the deaths attributed to myocardial infarction² and provide a challenging group of patients in which to develop ...

Non—small-cell lung cancer, which accounts for approximately 75 percent of the cases of lung cancer in the United States, represents a heterogeneous group of cancers, both biologically and histopathologically. Little progress has been made in their ...

For the past five years, the Journal has required that authors express all measurements in Système International (SI) units, although conventional units could also be given. This policy was adopted at a time when many medical journals in the United States ...

To the Editor: Christie and Marallo's article* on the conversion to Système International (SI) units is yet another strong plea to get on with it. Although the issue of SI units has been contentious, the authors have chosen not to acknowledge the ...

To the Editor: There is a simple explanation for the finding of McMurry et al. (Dec. 12 issue)¹ that the serum lipid levels of 13 Mexican Indians rose when they were fed an affluent, U.S.-style diet. The subjects gained an average of 3.7 kg (8 lb) during ...

To the Editor: Fletcher and Bulpitt (Jan. 23 issue)¹ conclude that "it appears reasonable to lower diastolic pressure to below 85 mm Hg," yet their figure shows that the lowest rate of mortality from coronary heart disease has been seen at a diastolic ...

To the Editor: Hug et al. (Dec. 26 issue)¹ suggest that neonates with deficiency of carnitine palmitoyltransferase type 2 could be treated by pharmacologic inhibition of carnitine palmitoyltransferase type 1, to decrease the formation of the long-chain ...

To the Editor: Wilson's disease is an autosomal-recessive disorder of copper metabolism characterized by the accumulation of copper in the liver, brain, and other organs. The cause of the defect is unknown. It is not possible to identify carriers with ...

To the Editor: Recently, we saw a young child with sporadic fatal infectious mononucleosis involving monoclonal proliferation of cytotoxic T cells containing the Epstein–Barr virus (EBV) genome. A two-year-old Japanese boy was admitted to the Kanagawa ...

To the Editor: The Health Policy Report by Iglehart (Dec. 19 issue)* provides a detailed discussion of recent actions to limit the referral of patients to facilities in which the referring physician has an ownership interest. Most knowledgeable parties ...

To the Editor: The competent patient has the right to make choices about medical interventions as well as to give advance directives to limit his or her care. A recent incident involving my father-in-law serves to remind us that choices may change over ...

Each of these five books is intended to be used as a textbook in a neuroscience course. In a textbook, a student reading the book is presented with material designed to highlight the important features of the subject and to organize them in such a way as ...

This book addresses the issues of informed consent, consent by proxy, and assessment of context-specific competency in persons with dementia. It originated in a symposium held in January 1989 and is the Canadian companion volume to Alzheimer's Dementia: ...

Dementia, now in its second edition, provides a clinically oriented review of progressive cognitive disorders. As the population of the United States ages, it becomes increasingly important for physicians to be aware of diseases that affect intellectual ...

Psychiatrists and neurologists, especially those dealing with children, frequently have what at first appear to be conflicting views of the many patients they share. Ask a psychiatrist whether autistic children have normal intelligence, and the answer ...

Psychotropic medication has recently received a lot of negative attention from the media. Even at professional meetings (such as those of the American Psychiatric Association), there have been demonstrations against certain drugs. Methylphenidate (Ritalin)...

MAYO FOUNDATION

The following will be offered in Rochester, Minn., unless otherwise indicated: "Mayo Euro Date 1992" (Vienna, Austria, and Budapest, Hungary, Aug. 19–25); "Update on Sleep Disorders" (Oct. 25); and "Gynecologic Clinical Reviews —1992" (...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...