IN April 1989, investigators from New Zealand reported the results of a case–control study in which the use of fenoterol, a selective β₂-agonist, was found to be associated with an increased risk of death from asthma.¹ The study found no similar increase ...

ALCOHOLIC hepatitis is a serious form of acute liver injury, with mortality in the hospital as high as 65 percent.¹ Conventional management consists of abstinence from alcohol, the correction of dietary deficiencies, and general support. Corticosteroid ...

THERE are two forms of autoimmune thyroiditis — atrophic autoimmune thyroiditis (idiopathic primary hypothyroidism) and goitrous autoimmune thyroiditis (Hashimoto's disease).¹ Hypothyroidism is a major feature of both disorders, thought to be due to the ...

ADVANCED carcinoma of the islet cells of the pancreas, although rare, presents a kaleidoscope of clinical challenges. In addition to the usual problems associated with primary and metastatic tumor bulk, patients with islet-cell carcinoma may have evidence ...

NON—SMALL-CELL lung cancer is the most frequent cause of death due to cancer in men in the Western world, and its incidence among women is rapidly increasing. The poor prognosis of patients with locally advanced tumors has remained essentially unchanged ...

APHASIA is a disturbance of the comprehension and formulation of language caused by dysfunction in specific brain regions. It results from a breakdown of the two-way translation that establishes a correspondence between thoughts and language. Patients ...

FOR more than 10 years, my colleagues and I have been testing the relatively simple hypothesis that the degeneration of connective tissue characteristic of many diseases is the result of genetic defects in the collagens that provide most of the strength ...

Presentation of Case

A 47-year-old man was admitted to the hospital for liver transplantation because of severe hepatic failure.

The patient was in a good general state of health until approximately six weeks earlier, when painless jaundice developed. ...

THE paper by Spitzer et al. in this issue of the Journal ¹ suggests that inhaled β-agonists may be responsible for an increase in the severity of asthma and a higher death rate from the disease. This is the latest in a series of papers that have ...

WE tend to think that the effects of any process that impairs thyroid function sufficiently to cause hypothyroidism are irreversible and that thyroxine-replacement therapy therefore needs to be lifelong. Some patients, however, regain normal thyroid ...

THE use of chemotherapy has resulted in substantial progress in the treatment of certain uncommon cancers, such as childhood leukemia, testicular cancer, and the lymphomas, whereas the more common epithelial tumors of adults have in general proved far ...

FACED with possible extinction, the private health insurance industry has emerged as a vocal advocate of reforming the way it does business. Since January 1990, the Health Insurance Association of America (HIAA) has proposed extensive regulation of the ...

To the Editor: The study by Ayanian and Epstein (July 25 issue)¹ suggests that sex bias affects physicians' decisions about patients with suspected or confirmed coronary artery disease. However, other possible interpretations of its results deserve ...

To the Editor: The article by Fernández-del Castillo et al. implicating calcium administration in the development of pancreatic cellular injury (Aug. 8 issue)¹ was of interest but was misleading on pathophysiologic and biostatistical grounds, since ...

To the Editor: In his recent article on inflammatory bowel disease (Sept. 26 issue),¹ Podolsky suggests that collagenous, lymphocytic, and possibly other "microscopic" colitides are "variant forms of ulcerative colitis." Furthermore, he suggests that ...

To the Editor: According to data presented by Lozoff et al. (Sept. 5 issue),¹ children who had moderate iron-deficiency anemia in infancy scored lower on tests of mental and motor development at five years of age than children who were iron sufficient. ...

To the Editor: The article "Allergic Rhinitis" by Naclerio (Sept. 19 issue)¹ provides an excellent review of many of the major problems encountered in this diverse disorder. However, the discussion of pathophysiology and treatment did not include the ...

To the Editor: Chlamydia pneumoniae has been described as a common cause of community-acquired pneumonia.^{1 , 2} We describe a case of Guillain—Barré syndrome that followed infection with C. pneumoniae.

A 13-year-old previously healthy boy was admitted to ...

The passage of the Americans with Disabilities Act in 1990 was a crucial event in the struggle to improve the quality of life of people with disabilities. Similarly, this book is a major step forward in developing a national program for the prevention of ...

Rarely in the business of reviewing new works does one have the opportunity to celebrate the organization of a book, in addition to its content and writing style. It is my privilege to do so in reviewing Children of Alcoholics, volume 9 of the series ...

Efforts to treat drug abuse with substitute narcotics date back to the years 1919 to 1923. Narcotic-drug clinics were closed in the mid19208, after a ruling by the Supreme Court prevented physicians from prescribing any narcotic substance to treat ...

This is a timely work, because the appalling figures on children of alcoholics (28 million people, or 1 of every 8 Americans) emphasize the growing social and economic importance of this group. Add to them the increasing number of persons dependent on ...

Two books to be considered together that might well occupy a similar place on the bookshelf are Adolescents at Risk and Youth Suicide. Our times are especially concerned with the behavior of young people, even though youth has always been a time of ...

This book is addressed to psychologists who treat suicidal patients. It deals with the clinical care of suicidal patients, along with the legal obligations and attendant liability risks. The hook in the book is the review of malpractice issues. The author ...

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OHIO STATE UNIVERSITY

The following courses will be offered in Columbus: "...

The Diagnostic Performance of Computer Programs for the Interpretation of Electrocardiograms (December 19, 1991;325:1767–73). On page 1767, in the Results section of the Abstract, the first sentence should have read, "The percentage of control patients ...