POSTMENOPAUSAL osteoporosis is a common disorder that results in substantial morbidity and mortality.¹ Many agents have been used to treat it, including estrogen, bisphosphonates, anabolic steroids, calcium, calcitonin, and sodium fluoride, of which the ...

AN increase in the incidence of cancer in patients with polymyositis, first noted in 1916,¹ has been reported in many studies^{2 3 4 5 6 7 8 9 10 11 12 13 14} from different countries, but this relation is not uniform.¹⁵ Estimates of the associated risk vary ...

THE presence of hyperpigmented macules (liver spots) on the face or other exposed areas usually indicates substantial damage due to exposure to sunlight (photodamage). To date, the treatment for such lesions, many of which are actinic lentigines, has been ...

HUMAN T-cell lymphotropic viruses Type I (HTLV-I) and Type II (HTLV-II) are closely related retroviruses.¹ HTLV-I is associated with adult T-cell leukemia and with myelopathy or tropical spastic paraparesis.² HTLV-II, first isolated from a patient with a ...

WE have previously reported an association between large-vessel peripheral arterial disease diagnosed with the noninvasive techniques of segmental blood-pressure measurement and determination of flow velocity by ultrasonography and the rate of mortality ...

NOT all aspects of the 1960s can be viewed with nostalgia. Nevertheless, many people have such feelings for the deep social concern of the times. During the 1960s Congress implemented Medicare and Medicaid and also initiated primary care programs for ...

The step-by-step process of clinical problem-solving is the subject of this new Journal feature. Information about a real patient is presented to an expert clinician in stages (boldface type), to simulate the way such information emerges in everyday ...

Presentation of Case

A 67-year-old right-handed man was referred to the hospital because of aphasia and memory loss.

The patient was well until 18 months earlier, when he began to have progressive difficulty in speaking and writing. During approximately ...

Osteoporosis is common among postmenopausal women. Unfortunately, in the past it was frequently regarded by clinicians as a normal part of aging, with little need for therapeutic intervention; during the past decade, however, it has increasingly been ...

In the late 1960s it was conventional wisdom that physicians were in short supply and unevenly distributed according to geography and specialty.¹ The shortage, if it ever really existed, was rapidly corrected, but geographic maldistribution — the relative ...

To the Editor: The Special Article by Hostetter et al. on the medical evaluation of internationally adopted children (Aug. 15 issue)* rendered a valuable service by calling attention to the high rate of serious but remediable medical problems in such ...

To the Editor: In their article entitled "Transmission of Hepatitis C Virus by Organ Transplantation," Pereira et al. (Aug. 15 issue)* lacked critically needed scientific proof to warrant their conclusions. Moreover, several statements in the report are ...

To the Editor: Under new Health Care Financing Administration rules, liver-transplantation programs must show a 77 percent rate of survival at one year among their patients to be accredited to receive Medicare funds. We believe this may place physicians ...

To the Editor: Tunis et al. (Aug. 22 issue)¹ question the use of balloon angioplasty, on the basis of an analysis of amputation rates over a 10-year period in Maryland hospitals. They noted a 24-fold increase in angioplasty, from 17 to 706 procedures, ...

To the Editor: Strict control of the composition of the diet for a prolonged period in order to observe dietary effects on serum lipid levels is particularly difficult in free-living subjects. Therefore, experimental data concerning the effects of ...

To the Editor: In the letter by Hanaki et al. (Sept. 12 issue),* the results of the plasma cholesterol and triglyceride measurements are given in millimoles per liter. In the calculation of the plasma concentration of low-density lipoprotein (LDL) ...

To the Editor: Many side effects of treatment with granulocytemacrophage colony-stimulating factor (GM-CSF) have been reported, including bone pain, fever, myalgias, and arthralgias. We describe a patient who had a reaction that we have not seen reported ...

Sometimes (although not often) new forms of medical technology raise unique legal and social-policy issues that require new laws. In vitro fertilization, followed by the transfer of the embryo to a woman who did not contribute the ovum, is such a ...

Early in this book, the authors lament, "'Doppler Physics' is a special incantation that turns an eager audience of students into lightly sedated glassy-eyed humans, convinced they are unable to learn such a difficult topic." I am happy to report that ...

The goal of this book is to provide perspective on the current role of percutaneous techniques in the treatment of valvular and congenital heart disease. Successful percutaneous balloon valvotomy for pulmonic stenosis was first reported in 1982, and since ...

The second edition of the Color Atlas of Liver Disease is a gem, a beautifully illustrated book that provides a useful overview of clinical liver disease. As a reflection of the rapid advances in our understanding of liver disease during the past decade, ...

This formidable textbook focuses on malignant hematologic disorders. It is divided into five sections, on chronic leukemia and related disorders, acute leukemia, myeloma and related disorders, lymphoma, and supportive care. The four disease-related ...

The relatively young field of nephrology has become a major subspecialty of internal medicine. Not surprisingly, as the field has grown, so has the number of textbooks on the subject. It has grown to such an extent that when a new textbook is published, ...

This book could become the Washington Manual for renal disease. The clear, concise writing makes it an excellent book for medical students on a nephrology rotation, house officers, and new nephrology fellows. All needs can be served because Care of the ...

This monograph on calcium metabolism fills a void. It is a single-authored work of excellent quality that encompasses the basic and clinical aspects of calcium homeostasis. There are separate chapters on general concepts of calcium homeostasis; the role ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

PHARMACEUTICALS

The following conferences will be held in Washington, D.C: "...

Genetic Basis of Familial Amyotrophic Lateral Sclerosis (November 7, 1991;325:1382–3). On page 1382, in the letter by Eldridge and Alberstone, in the fifth line of the first paragraph, "chromosome 4" should have read "chromosome 21."

In the fourth line of ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...