THE widespread use of antimicrobial agents for prophylaxis has altered surgical practice markedly in the past 20 years and now represents one of the most frequent uses of antibiotics in hospitals, accounting for as many as half of all antibiotics ...

A THROMBUS overlying a disruption in the fibrous cap of an atherosclerotic plaque in a coronary artery is considered to be the cause of both unstable angina and acute myocardial infarction.^{1 2 3 4 5} Recently, the administration of antiplatelet agents, ...

IN the past five years, the importance of group A streptococcal infections has increased in North America and Europe as well as in other parts of the world.¹ In Northern Europe, the number of life-threatening infections caused by group A streptococci has ...

BRONCHIAL inflammation in asthma may depend in part on the activation of T helper lymphocytes that elaborate proinflammatory cytokines. CD4-positive lymphocytes in peripheral blood from patients with severe acute asthma demonstrate increased expression of ...

IN 1988, U.S. cigarette manufacturers spent $3.27 billion on cigarette advertising and promotion, the equivalent of $100 per second. Eleven percent of that amount, or $355 million, was devoted to magazine advertising, making cigarettes the second most ...

The Pathogenesis of Thrombus Formation

Having discussed the participation of thrombus formation in the progression of atherosclerosis and in the acute coronary syndromes (Fig. 2 and 5), we shall now examine the local and systemic factors present at the ...

UPPER respiratory tract infections are the most common clinical problems for primary practitioners who care for children. It has recently been estimated that approximately 5 to 10 percent of upper respiratory infections in early childhood are complicated ...

Presentation of Case

A 20-year-old man was admitted to the hospital because of diffuse pulmonary infiltrates, respiratory failure, and disseminated intravascular coagulation.

The patient was well until 11 months earlier, when a peritonsillar abscess ...

POSTOPERATIVE wound infections affect at least 920,000 of the 23 million patients who undergo surgery each year in the United States.¹ The rates of infection vary according to the procedure: less than 3 infections per 100 for clean procedures (i.e., those ...

THE group A β-hemolytic streptococci, of the species Streptococcus pyogenes, can sicken or kill us in many ways. They commonly cause acute pharyngitis. They may initiate rheumatic fever or glomerulonephritis. They also cause scarlet fever, impetigo, ...

OREGON'S plan to base Medicaid benefits on a prioritized list of health services has attracted national interest as a novel approach to financing medical care for the uninsured.^{1 2 3 4 5 6 7 8 9 10 11 12 13} The goal is to provide basic health care ...

To the Editor: Tønnesen et al. (Aug. 1 issue)* provide some highly interesting and pertinent information on the potential effectiveness of a transdermal nicotine patch, used over the 16-hour period of wakefulness, in helping patients who wish to quit ...

To the Editor: The saucerization skin biopsy condemned by Koh (July 18 issue)¹ is the biopsy preferred by many dermatologists for selected pigmented lesions. These are small lesions (1 cm or less) for which the clinical diagnosis is benign (such as ...

To the Editor: Redfield et al. (June 13 issue)¹ reported the initial results of a phase I evaluation of the safety and immunogenicity of vaccination with recombinant gp160 in patients with human immunodeficiency virus (HIV) infection. They concluded that ...

To the Editor: With regard to the Johnson Controls case, discussed by Annas in the Journal (Sept. 5 issue),¹ although the decision reached was "consistent with good medical practice,"¹ the analysis employed in reaching that decision is problematic.

We ...

To the Editor: Intramuscular injection of type A botulinum toxin alleviates the symptoms of several movement disorders, with few adverse effects.^{1 2 3 4 5 6} In disorders such as torticollis, the large doses used may result in the development of ...

To the Editor: An increasing number of direct-to the-public advertisements have recently appeared in print and in the electronic media. Cohen, in a 1988 Sounding Board article in the Journal ^,* predicted this trend and clearly described many of the ...

To the Editor: The following case report describes a practical response to a dangerous, cold-induced injury.

One March night in Alaska, 30 miles north of the Arctic Circle, a five-year-old Eskimo boy was out for the evening with his father, attending the ...

To the Editor: Amundsen—Scott Station, located at the South Pole, is a U.S. Antarctic research base. For 3 1/2 months during the austral summer the station is visited frequently by ski-equipped C-130 Hercules aircraft. This only means of transportation ...

The original title of this extremely interesting book, Music and Medicine, was more appropriate than the present, melodramatic one. The book contains medical investigations into the lives of 20 great composers, from Bach to Gershwin, but the author deals ...

After an account of Aztec culture in Meso-America at the time of the Spanish Conquest, including a discussion of 16th-century Spanish sources, the author briefly discusses Aztec religion, cosmology, and medicine. He devotes two chapters to the population-...

In the middle of January 1953, the Soviet media announced that a group of prominent physicians, most of whom were consultants to the Kremlin, had been arrested for conspiring, at the behest of Western intelligence organizations and through the (Jewish) ...

This is a good book, especially for those interested in endocrinology. It gives an insider's view of a place important in the explosion of medical knowledge and understanding during the past eight decades.

Although the book bears no formal dedication, the ...

This book is a collection of papers that were presented at a conference at the University of Texas Health Sciences Center in Houston in June 1989. The authors include physicians, philosophers, health care administrators, and specialists in health care ...

Darwin's theory of evolution by natural selection is based on three tenets: organisms vary, this variation is heritable, and this variation is subject to selection. This book contains interesting and useful essays on the diversity that is biology, but ...

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