CYTOMEGALOVIRUS (CMV) retinitis is the most common intraocular infection in patients with the acquired immunodeficiency syndrome (AIDS), affecting an estimated 20 percent of them.^{1 2 3 4 5 6 7 8 9 10} Untreated, CMV retinitis is a progressive and ...

IN as many as 40 percent of the cases of cerebral infarction reported in the stroke data bank of the National Institute of Neurological Disorders and Stroke,¹ the cause is undetermined. Recent studies with transesophageal echocardiography have found ...

SYNTHETIC glucocorticoids are commonly used drugs.¹ One of their major limitations in long-term use is suppression of pituitary—adrenal function.^{2 , 3} The degree of such suppression is believed to depend on many factors, such as the duration and dosage of ...

INFECTION with the human immunodeficiency virus (HIV) has had a substantial impact on the global epidemiology of tuberculosis.^{1 , 2} By causing a progressive and ultimately profound reduction in cell-mediated immunity, HIV infection increases the risk of ...

EFFECTIVE control of iodine deficiency by iodine supplementation is still a challenge in developing countries.¹ Provision of iodized salt is often unsuccessful because of unfavorable climatic or economic conditions, a shortage of iodized salt in local ...

IN the 19th century there were two major hypotheses to explain the pathogenesis of atherosclerosis: the "incrustation" hypothesis and the "lipid" hypothesis. The incrustation hypothesis of von Rokitansky,¹ proposed in 1852 and modified by Duguid,² ...

WHEN doctors prescribe antihypertensive drugs they face a dilemma. They are well aware that the benefits of lowering blood pressure in patients with hypertension far outweigh the risks, yet they have been warned that at some level of lowered blood ...

Presentation of Case

A 52-year-old man was admitted to the hospital because of pancytopenia.

There was a 25-year history of adult-onset diabetes mellitus, which was managed elsewhere with NPH insulin (42 U) and regular insulin (6 U) taken daily before ...

TWO drugs, ganciclovir and foscarnet, are currently licensed for use in the treatment of cytomegalovirus (CMV) retinitis, one of the most common and devastating afflictions of persons with advanced human immunodeficiency virus (HIV) infection. Ganciclovir,...

THIS issue of the Journal contains a report by Schlaghecke et al. on the responsiveness of the hypothalamic—pituitary—adrenocortical (HPA) axis in patients treated daily with corticosteroids.¹ The authors demonstrate that testing with corticotropin-...

IODINE is necessary for thyroid hormone production. Its deficiency causes mental retardation, deafmutism, short stature, goiter, and an increased risk of death in childhood and leads to socioeconomic deprivation.¹ About one fifth of the earth's population,...

To the Editor: As a clinical hematologist, I am glad to see granulocyte colony-stimulating factor (G-CSF) become available for clinical use. However, in view of a recent critique of the cost effectiveness of intravenous preparations of immune globulin in ...

To the Editor: Intravenous immune globulin is used as an immunomodulatory agent in various autoimmune diseases.¹ Adverse effects are uncommon but may include vasomotor symptoms such as chills, nausea, flushing, tightness of the chest, and wheezing.² ...

To the Editor: Hering¹ and Lewis² first described the presence of alternating morphology on the electrocardiogram, and this phenomenon was subsequently observed in several experimental and clinical circumstances, including coronary-artery ligation,^{3 4 5} ...

To the Editor: The study by Sharief and Hentges (Aug. 15 issue)¹ provides evidence that cerebrospinal fluid levels of tumor necrosis factor-α are higher in patients with chronic progressive multiple sclerosis than in patients with stable disease and that ...

To the Editor: The study by Buzby et al. (Aug. 22 issue)¹ should not be interpreted as casting doubt on the efficacy of total parenteral nutrition. Instead, it points out the difficulty in determining which, if any, surgical patients might benefit.

Since ...

To the Editor: In their article on indebtedness among medical students (Aug. 8 issue),¹ Hughes et al. shed little new light on the complex causes of and potential remedies for this elusive problem, which caught the attention of authors as long as 10 ...

To the Editor: We report an unusual cause of apparent hemoptysis in a 79-year-old man. He had smoked 20 cigarettes per day for 50 years, until 1980. In 1985 hemoptysis developed; bronchoscopic biopsy revealed a moderately differentiated squamous-cell ...

In this well-written and well-translated book the authors, a pediatric radiologist and an anatomist, have succeeded in producing a much needed, practical integration of embryology, anatomy, physiology, and diagnostic imaging of the immature and term ...

This multiauthored book, commissioned by the Royal College of Radiologists, deals with the state of the art in the imaging of major abdominal organs exclusive of the intestine. It was written by 33 contributors from the United Kingdom and is divided into ...

Genitourinary radiology has long been a subspecialty without adequate textbook resources for its residents and for practicing radiologists in need of a reliable, up-to-date reference work. Furthermore, our clinical colleagues have been trying to keep up ...

This is not just another textbook on how to read electrocardiograms but rather, as the title suggests, an advanced textbook of practical clinical electrocardiography. It is organized for quick reference by chapters and is well structured within chapters. ...

Despite differences in objectives, cardiac ultrasound technologists and physician-interpreters of cardiac ultrasound examinations share a large base of knowledge. The accomplished technologist must possess sufficient clinical knowledge to address the ...

Molecular biologic techniques have helped to define the genetic and biochemical alterations underlying many human diseases. This new technology has identified specific DNA sequences linked to genetic diseases and made carrier detection and prenatal ...

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CALL FOR ABSTRACTS

Abstracts are being accepted for the "2nd International ...

Transplacental Passage of Insulin in Pregnant Women with Insulin-Dependent Diabetes Mellitus — Its Role in Fetal Macrosomia (August 2, 1990;323:309–15). On page 312, in the left-hand column, the 18th line of text should have read, "6.14±1.7 and 1.6±0.43 ...

Gastrointestinal Endoscopy (in two parts) (October 17, 1991;325:1142–9, October 24, 1991;325:1214–22). In the first part, on page 1149, reference 114, the inclusive page numbers should have been 1–5, not 575–8, as printed. We regret the error.

In the ...