ONCE an endocrine tumor of potential pancreatic origin has been diagnosed on the basis of clinical signs and laboratory tests, surgery has to be performed in order to cure the disease, at least in patients who do not have metastases. Of the various ...

CHRONIC renal disease in children is frequently due to a congenital renal lesion, such as aplasia or dysplasia, which leads to end-stage renal disease in early infancy. Such children have retarded growth and renal osteodystrophy. Dialysis therapy tends to ...

THE two most common components of Graves' disease are hyperthyroidism and ophthalmopathy. There is usually a close temporal relation between the onset of the two conditions, but ophthalmopathy can develop long before or after the onset of hyperthyroidism.^...

DIGITALIS preparations, widely prescribed for children and adults with heart disease,^{1 2 3 4} are potent medications that in excessive doses may have cardiac, gastrointestinal, neurologic, and metabolic effects. Although there are case series of digitalis ...

SINCE the mid-1970s adjuvant chemotherapy has been widely used to treat breast cancer with regional lymph-node involvement.¹ More recently, systemic drug therapy has been given to women with localized disease, most of whom survive for many years without a ...

KALLMANN'S SYNDROME is an inherited disorder characterized by hypogonadism and anosmia.¹ The hypogonadism is due to deficiency of gonadotropin-releasing hormone (GnRH),² and the anosmia is due to hypoplasia or aplasia of the olfactory bulbs and tracts.^{3 ,} ...

Approximately 186,000 new cases of breast cancer will occur in the United States in 1992, and about two thirds of these cases will not involve axillary nodes. This means that each month decisions about adjuvant therapy will be made for more than 10,000 ...

Presentation of Case

A 38-year-old man was admitted to the hospital because of gradually progressive right hemiparesis.

There was a long history of morbid obesity. The patient attained a weight of 118 kg at the age of 12 years and a maximal weight of 150 ...

THE localization of islet-cell tumors producing insulin and gastrin continues to challenge endocrinologists, radiologists, and surgeons. Since no single imaging study has emerged as being clearly superior and safe, we continue to perform an array of ...

MOST physicians treat patients with hyperthyroidism caused by Graves' disease with either an antithyroid drug or radioactive iodine (iodine-131). Which treatment the physician recommends is based on factors such as the patient's age, the risk of side ...

WELL over half, and possibly as many as three fourths, of all women in whom breast cancer is diagnosed are cured, usually by mastectomy or lumpectomy plus radiotherapy. The chance that a woman with breast cancer will eventually die of the disease is ...

THE analysis by Bick et al. in this issue of the Journal ¹ closes the circle on a rapidly evolving set of discoveries that have implicated the function of a defined protein in neuronal migration. Specifically, these investigators have identified, as the ...

To the Editor: I believe that the answer to Dr. Petersdorf's question about "why being a generalist is the norm for 50 percent of the physicians in Canada and 70 percent of those in the United Kingdom" (Feb. 6 issue)* is twofold. First, the governments ...

To the Editor: The case entitled "The Many Pitfalls in the Diagnosis of Myeloma" (Feb. 6 issue)* in your new feature "Clinical Problem-Solving" proves the format to be both instructive and entertaining. However, Dr. Duffy's comments suggest that the ...

To the Editor: Warshaw and Fernández-del Castillo's presentation (Feb. 13 issue)¹ of surgical resection as the sole option for potentially resectable small adenocarcinoma (<2 cm in diameter) of the pancreatic head skirts the substantial disadvantages of ...

To the Editor: In a study similar to that by Khabbaz et al. (Feb. 6 issue)¹ on the seroprevalence of human T-cell lymphotropic virus (HTLV) infection among intravenous drug users in the United States, we evaluated the seroprevalence in Italy of ...

To the Editor: Continuous mediastinal irrigation with povidone—iodine is a standard treatment for mediastinal infection occurring as a complication of cardiac surgery.¹ However, systemic absorption of iodine during mediastinal irrigation or topical ...

To the Editor: Although fatal crashes primarily involve younger drivers, fatal-crash rates per million miles driven increase substantially for drivers 65 years of age or older.¹ Visual acuity also decreases markedly after the age of 65,² and this ...

To the Editor: Listening to presentations by medical students and house staff, I continually hear patients described in terms of their merit as historians — for example, "This 53-year-old white woman was a poor historian." This locution always takes me ...

In preparing this second edition of their monumental textbook, the editors state, they learned "from reviews and discussions with leaders in the field that... [the first edition's] format, content, and structure... did not achieve their original ...

In this book Gerald Grob, a well-known medical historian, carefully documents the social changes and political influences that converged to shape mental health policy from the 1940s through the 1970s. Beginning with a brief but poignant description of the ...

The United States spends more per capita on medical care than any other country, even though a large proportion of the American population does not have ready access to medical care. We are spending public resources disproportionately for the medical care ...

This book is one of the best summaries of research on personal violence available. The subtitle "A Public Health Approach" is an understatement. This is, in fact, the most comprehensive review of data sources on the causes, consequences, and prevention of ...

When a Child Kills is a well-written, compelling, and important description of eight cases of parricide, an uncommon tragedy. There are "just" 300 murders of parents each year in the United States, among the 2 million cases of reported child abuse and 23,...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits. The Journal does not publish unsolicited ...

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CALL FOR PROPOSALS

The Robert Wood Johnson Foundation is requesting proposals ...