MEDICAL neurology and the neurosciences have made astonishing progress in the past few decades. New imaging techniques permit visualization of not only the gross anatomy but also aspects of the biochemical and pharmacologic features of the living, working ...

Presentation of Case

A 52-year-old man came to the hospital for further management of hypertension.

The patient was an unemployed construction worker. There was a history of hypertension of 12 years' duration, with difficulty in control and a known ...

THE potential importance of magnetic resonance (MR) imaging in the evaluation of vascular disease was recognized early in the history of this technique.^{1 , 2} Its suitability for vascular imaging stems from the fact that flowing blood produces a unique ...

DEVELOPMENTS in flexible endoscopy have had an enormous effect on the management of many gastrointestinal, biliary, and pancreatic diseases during the past two decades.¹ Diagnostic endoscopy has largely superseded barium radiology, and endoscopically ...

WHEN pregnancy is prolonged beyond 42 weeks of gestation, perinatal mortality increases. The nadir of perinatal mortality, 7 per 1000 live births, is at a weight of about 3500 g and a gestational age of 39 weeks. At 41 weeks of gestation the rate is 9 per ...

FOR oncologists, who deal with disabling and life-threatening diseases on a daily basis, esophageal cancers represent an unusually difficult problem. Although these cancers are not especially common, they produce enormous suffering and a high death rate, ...

To the Editor: In their article comparing angioplasty with medical therapy in the treatment of single-vessel coronary artery disease (Jan. 2 issue),* Parisi et al. conclude that in treating single-vessel disease, percutaneous transluminal coronary ...

To the Editor: The editorial on the study of the accuracy of computerized electrocardiography (Dec. 19 issue)* illustrates the dilemma in which American medicine finds itself. The conclusion of Drs. Laks and Selvester that "every computerized ECG [...

To the Editor: The well-designed study by Michels et al. (Jan. 9 issue)¹ provides further evidence that the percentage of patients with idiopathic dilated cardiomyopathy who have familial disease is higher than previously thought. It should be noted, ...

To the Editor: I believe that the recent article by Dwyer (Jan. 9 issue)¹ contains misstatements about the neurologic diseases discussed and probably overestimates the efficacy of intravenous immune globulin in those diseases.

The section describing the ...

To the Editor: The report by Rajfer et al. on the role of nitric oxide in penile erection (Jan. 9 issue)¹ confirms previous reports that have addressed this issue and reached similar conclusions.^{2 3 4} These reports address some of the important questions ...

To the Editor: We wish to draw attention to the inadequacy of fluorescence in situ hybridization (FISH) with cells at interphase as an alternative to karyotype analysis for the prenatal diagnosis of chromosome aneuploidy.

On the basis of the results of a ...

To the Editor: On February 11, 1992, President George Bush announced that the United States would accelerate the phase-out of many chlorofluorocarbons. This decision was reportedly based on a study by the National Aeronautics and Space Administration ...

DNA typing, sometimes called DNA fingerprinting or profiling, has been the focus of heated exchanges in courtrooms, the popular press, and scientific journals. It is a powerful law-enforcement weapon, especially in cases of rape, because it has the ...

This is a reasonably well written summary of the many legal issues that touch on contemporary medical practice, in particular the practice of anesthesiology. As such, we recommend it to practicing physicians and to all others involved in health care ...

First-time purchasers of anesthesiology textbooks must choose among scores of competing titles ranging from featherweight handbooks through middleweight hardcover titles to heavyweight multi-volume sets. A new contender in the lightweight, portable ...

Over the past 20 years, the field of anesthesiology has grown exponentially to the point that it now includes a number of complex specialties. New developments are occurring so rapidly that it is becoming increasingly difficult for clinicians, especially ...

Weighing in at more than 2 kg each, with small type (on matte, easy-to-read paper), plentiful, well-chosen illustrations, voluminous chapter bibliographies, and detailed indexes (spanning four dozen pages each), these books are serious reading. Their ...

In the introduction to this edition of his Dictionary (a revision of the 1969 edition), Jablonski describes the somewhat surprising history of the word "syndrome" itself. Derived from the Greek word syn (together) combined with dromos (a course, things ...

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EUROPEAN INTENSIVE BIOETHICS

The seminar will be held in Nijmegen, the ...

Activating Mutations of the Stimulatory G Protein in the McCune–Albright Syndrome (December 12, 1991;325:1688–95). On page 1689, in the right-hand column, under the heading "PCR Amplification of Genomic DNA," the first sentence should have begun, "Either ...

I Weep (March 12, 1992;326:770). The first line of the poem should have read, "Weary we are, we end," not "Weary are we, we end," as printed. We regret the error.

Case Records of the Massachusetts General Hospital (Case 17–1992) (April 23, 1992;326:1137–46). On page 1142, in the right-hand column, under the heading "Pathological Discussion," the sentence beginning in the 3rd paragraph, 6th line, should have read, "...

THE use of endoscopic papillotomy and nasobiliary drainage, either alone or in combination, is a satisfactory alternative to emergency exploration of the common bile duct in the treatment of patients with acute cholangitis due to choledocholithiasis.^{1 2 3} ...

APPROXIMATELY 10 percent of all pregnancies last longer than 41 to 42 weeks,^{1 , 2} and the risk of perinatal death increases in pregnancies that last 2 or more weeks beyond the due date.^{2 3 4} Much of this perinatal mortality is related to asphyxia with or ...

PROGRESS has been slow in the treatment of patients with esophageal cancer, which accounts for 1.8 percent of cancer deaths in the United States and affects more than 10,000 patients annually. The results of surgery and radiation therapy have been poor, ...

PRADER—WILLI syndrome is a complex developmental and neurobehavioral genetic disorder affecting approximately 1 in 10,000 newborns.¹ It represents the most common dysmorphic form of obesity, with more than 700 cases reported.² Clinical diagnosis of Prader—...

With improvements in the techniques of vascular surgery, bypass grafting to very small distal vessels to save a limb has become possible. Grafts to the arteries of the foot are now standard vascular surgical practice. As the options for salvaging limbs ...