Familial Mediterranean fever is a disorder characterized by intermittent attacks of fever with abdominal pain, pleurisy, or arthritis; its symptoms are not apparent between attacks. This inherited autosomal-recessive disease affects primarily members of ...

TUBERCULOSIS is an increasing cause of morbidity among persons with human immunodeficiency virus (HIV) infection in the United States.¹ As the number of patients hospitalized with HIV infection and tuberculosis increases, the risk of nosocomial ...

MANY studies have identified racial differences in infant mortality in the United States.^{1 2 3 4 5 6} Although infant mortality rates have declined dramatically during this century, the gap between the mortality rates of black and white infants born in the ...

ENDOSCOPIC sclerotherapy is an accepted treatment for both acute and definitive management of bleeding esophageal varices. Most studies indicate that sclerotherapy is superior to medical management when results are measured by the control of active ...

SEVERAL studies have described the clinical signs and symptoms of persons who present to referral or research clinics with classic genital herpes simplex virus (HSV) infection.^{1 2 3 4} The full clinical spectrum of genital herpes in sexually active adults ...

DURING the past two decades, important insights have been gained into the pathogenesis of asthma. Despite our greater knowledge, national statistics reveal increasing morbidity and mortality due to this disease.^{1 , 2} This paradox has led to a reevaluation ...

The step-by-step process of clinical problem-solving is the subject of this Journal feature. The authors present information about a real patient (boldface type) to an expert clinician in stages to simulate the way such information emerges in everyday ...

Presentation of Case

A 55-year-old man was admitted to the hospital because of recurrent pericardial and pleural effusions after aortic-valve replacement.

The patient was in stable health until eight months earlier, when a murmur of aortic regurgitation ...

Over the past three decades, the infant mortality rate has declined dramatically for all racial groups in the United States. Yet despite this impressive decline, powerful racial disparities persist. Over the past decade, the mortality rate among white ...

"Futility" is one of the newest additions to the lexicon of bioethics. Physicians, ethicists, and members of the media are increasingly concerned about patients and families who insist on receiving life-sustaining treatment that others judge to be futile. ...

To the Editor: Packer et al. (Nov. 21 issue)¹ reported that the unfavorable effect of milrinone on the survival of patients with severe congestive heart failure contrasted with the results of previous studies in laboratory animals. The authors suggested ...

To the Editor: Saag et al. (Jan. 9 issue)¹ compared intravenous amphotericin B with oral fluconazole in the treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome (AIDS). The data reported indicate that patients ...

To the Editor: Although Steinhoff et al. (Dec. 26 issue)¹ provide important insights into the immunologic responses of patients with human immunodeficiency virus (HIV) infection to Haemophilus influenzae type b vaccines, I am concerned that their finding ...

To the Editor: In a letter in the April 4, 1991, issue of the Journal,* we provided data on a relation between the mean plasma concentration of zidovudine and the occurrence of opportunistic infections. We have discovered a computational error in the ...

To the Editor: Carbon monoxide poisoning is a leading cause of accidental death and suicide, accounting for approximately 3500 deaths per year in the United States.¹ Because of the shortage of organs available for transplantation, the routine rejection ...

To the Editor: We agree with the statement of Cohen and Cohen in their Sounding Board article on do-not-resuscitate (DNR) orders in the operating room (Dec. 26 issue)* that a policy of "required reconsideration" and a negotiated suspension of the DNR ...

To the Editor: Thousands of athletes will gather in Barcelona this summer for the next Olympiad. Many people will travel to Spain to attend the Olympics, and many more will go to Seville for the world's fair, held from April 20 to October 12, 1992. ...

Laboratory Medicine: Test Selection and Interpretation is a new multiauthored comprehensive textbook, with sections devoted to each of the major subspecialties of laboratory medicine, including chemistry, hematology, immunology, microbiology, and blood ...

The author's stated aim in writing this book is to help clinicians and physicians in training understand traditional and newer techniques used in electrophoresis. The 15 relatively short chapters are essentially divided into four groups: physiopathologic ...

Today's cytopathologist is challenged by clinicians to do more with less on behalf of patients. "Doing more" includes providing more specific diagnoses than were previously possible, as well as novel ancillary information of therapeutic or prognostic ...

The second edition of this book, intended primarily as a practical guide to the pathologic processes of muscle for histopathologists, generally fulfills its goals. It is well organized and well written, and it contains some very useful tables and usually ...

In 15 chapters by 21 authors representing many of the world's authorities, Singer and Wallach have brought together papers from a conference supported by the Paget's Disease Foundation in New York in October 1989. The first three chapters of Paget's ...

Mountain medicine, a subdiscipline under the rubric of wilderness medicine, originated in response to the medical dramas enacted by intrepid explorers and alpine wanderers who were consumed by avalanches, succumbed to hypothermia, lost digits to frostbite,...

Insect Sting Allergy is the most complete and detailed treatise on the subject in the medical literature. Its target audience is the allergist or immunologist who diagnoses and treats allergic reactions caused by insects, but all physicians, regardless ...

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CALL FOR ABSTRACTS

Abstracts are now being accepted for the "1st ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...