HUMAN herpesvirus 6 (HHV-6) was first isolated from the peripheral-blood mononuclear cells of six adult patients from the United States and Jamaica who had lymphoproliferative diseases.¹ Subsequent isolations from patients in a number of additional ...

The clinical importance of shifts in ST segments of the electrocardiogram that are unaccompanied by angina pectoris or anginal equivalents (silent myocardial ischemia) is a topic of considerable interest and debate.^{1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16} ...

HEMANGIOMA of infancy is an angiomatous disorder characterized by the proliferation of capillary endothelium, with multilamination of the basement membrane^{1 , 2} and the accumulation of mast cells, fibroblasts, and macrophages.^{3 , 4} In this angiogenic ...

AMYOTROPHIC lateral sclerosis (ALS) is a chronic progressive disease of unknown pathogenesis that is characterized by the selective degeneration of upper and lower motor neurons. It is the cause of death in 1 in 1000 people. As a result of recent reports ...

IN recent years, analysts in both the academic and policy-making communities have come to believe that the supply of primary care physicians in the United States is inadequate to meet the needs of the population.^{1 , 2} In the light of this perception, the ...

ALTHOUGH osteonecrosis, the in situ death of a segment of bone, has been recognized since the early part of this century, it still presents challenges to the biologist, the physician in the applied sciences, and especially the clinician. Since the first ...

Presentation of Case

A 6 1/2-year-old girl was admitted to the hospital because of status epilepticus.

The patient was the only child of a mother 30 years old at delivery and a father 35 years old. The child was delivered by cesarean section, reportedly ...

SUDDEN death from cardiac causes continues to be a major clinical problem, with more than 300,000 victims a year in the United States alone. Improvements in the emergency management of out-of-hospital cardiac arrest have permitted the resuscitation of ...

Just over a decade ago, interferon alfa-2 produced by recombinant-DNA technology was introduced into clinical trials. An American Cancer Society initiative, which had confirmed the antitumor activity of leukocyte interferon laboriously produced from units ...

The dicarboxylic amino acid glutamate is not only an essential amino acid but also a signaling substance, serving as a workhorse neurotransmitter at many excitatory synapses in the central nervous system. Glutamate is present in millimolar concentrations ...

To the Editor: The study by Gray et al. (Nov. 14 issue)¹ adds to the considerable information accumulated to date about the futility of in-hospital resuscitation after advanced cardiac life-support measures used before the victim's arrival at the ...

To the Editor: In their article on medical problems associated with underwater diving (Jan. 2 issue),¹ Melamed et al. state, "In principle, diving is absolutely contraindicated in persons subject to spontaneous pneumothorax, as well as in those with air-...

To the Editor: Donated blood has been screened for antibody to the human immunodeficiency virus (HIV) at U.S. blood-collection centers since March 1985, which should virtually eliminate the risk of acquiring infection with HIV by this route. Nonetheless, ...

To the Editor: Both ultraviolet and visible radiation can damage ocular tissues, especially the lens and the retina.¹ Recent developments have drawn attention to both sunlight and artificial light sources. Increased outdoor levels of ultraviolet ...

To the Editor: The Patient Self-Determination Act, discussed by Wolf et al. (Dec. 5 issue),* makes it likely that health care providers will have knowledge of the existence of an advance directive for care, but it does not ensure knowledge of its ...

To the Editor: Drs. Murray and Rubel (Jan. 2 issue)* provide a thought-provoking but, I fear, overly tolerant look at alternative health care practices. I am curious about what, if any, indication the authors have that alternative health care providers ...

To the Editor: Estimates of birth weight made during labor in pregnancies at term are often inaccurate. Clinical assessment by the physician using Leopold's maneuvers or fundal-height measurement has a high error rate because of maternal obesity, uterine ...

The evaluation and treatment of patients with peripheral neuropathies are among the more difficult and less rewarding aspects of neurology and medicine. However, over the past decade the number of potentially treatable forms of peripheral neuropathy has ...

This is the fourth edition of a popular textbook that introduces the reader to vascular diseases of the central nervous system. This single-authored book by a well-known clinician and educator is well written. It is divided into 27 chapters dealing with ...

Although it is not described as such, this book seems to be the proceedings of a symposium. The fact that its publication was supported by an educational grant from Glaxo is mentioned. The book contains 49 relatively short papers, most of them research ...

This book belongs in every serious library on headache. With the recent death of John Graham, Ottar Sjaastad, the author of this book, is thought by many to be the most knowledgeable specialist on cluster headache. This book illustrates why. It contains ...

What is neuro-ophthalmology? Kestenbaum, in the preface to the first edition of Clinical Methods of the Neuro-ophthalmologic Examination (New York: Grune and Stratton, 1946), wrote that neuro-ophthalmologists use ophthalmologic tools and techniques to ...

A continuing observation by physiology instructors is that medical students prefer Guyton's textbook to others. This is understandable; it has the consistent style of a traditional, single-author textbook that maintains students' interest through clinical ...

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AIDS

A conference, entitled "A World United Against AIDS: 8th International ...