HEREDITARY mutations of tumor-suppressor genes have been correlated with a genetic predisposition to cancer, and several such genes have been linked to distinct familial cancer syndromes.¹ The best-studied example is retinoblastoma; about 40 percent of ...

THE p53 tumor-suppressor gene, located on the short arm of human chromosome 17,^{1 , 2} encodes a 53-kd nuclear phosphoprotein involved in the control of cellular proliferation.^{3 4 5 6 7} Acquired mutations in p53 are the most common tumor-specific genetic ...

THE existence of a chemical excitant of the endocrine pancreas was suggested as early as 1906.¹ This idea gained support in 1930, when it was demonstrated that the intravenous injection of crude secretin caused hypoglycemia in dogs by stimulating the ...

ONE of the strongest predictors of a woman's risk of breast cancer is the presence of the disease in her immediate family, especially if the relative had bilateral breast cancer^{1 2 3} or had the disease early in life.^{3 4 5 6 7 8 9} The association of family ...

WITH the final implementation of the Medicare fee schedule in January of this year, the renegotiation of a political bargain first struck more than 25 years ago was successfully concluded. To secure a reluctant profession's cooperation with Medicare, ...

ACTIN is the most abundant protein in mammalian cells. Cell motility and change in the size and shape of cells depend on the ability of monomers of actin to polymerize to actin filaments. When actin is released from cells, however, its strong tendency to ...

Presentation of Case

A 24-year-old man was admitted to the hospital because of nausea and epigastric pain that were unrelieved after a posterior gastropexy for a hiatal hernia.

There was a history of adrenocorticosteroid-dependent asthma since childhood, ...

OVER the past 15 years an examination of cancerous tissues has led to the identification of alterations in a number of genes that regulate cell growth and proliferation.¹ These mutations have been identified in two distinct categories of genes, oncogenes ...

THE connection between the gastrointestinal tract and pancreatic islets has been described as the enteroinsular axis.¹ It comprises a network including nutrients, enteric hormones, and neural signals that together mediate or modulate the release of islet-...

ADVERTISING by health maintenance organizations (HMOs) has become increasingly common in the United States. But unlike advertising by private physicians, which has generated considerable controversy,^{1 2 3 4 5 6} advertising by HMOs has been virtually ...

To the Editor: The report by Swift et al. (Dec. 26 issue)¹ of an elevated risk of breast cancer in a prospective study of patients who were heterozygous for ataxia—telangiectasia (relative risk, 5.1) is consistent with their own retrospective study and ...

To the Editor: The recent letter from Shannon and Graef (Jan. 9 issue)¹ regarding the hazard posed by lead in infant formula prepared with tap water undermines previous findings about the hazard of chronic exposure to lead in this age group and presents ...

To the Editor: Baud et al. (Dec. 19 issue)¹ concluded from their study of victims of smoke inhalation that an elevated plasma lactate concentration is a useful indicator of cyanide toxicity. The data do not adequately support this interpretation.

In Baud ...

To the Editor: Immunosuppression with cyclosporine in recipients of solid-organ transplants is associated with the development of Epstein–Barr virus (EBV)—related malignant lymphomas.^{1 , 2} We describe a patient in whom a similar lymphoma developed after ...

To the Editor: We recently encountered in two patients a rare systemic complication of the topical administration of cyclopentolate hydrochloride (Cyclogyl) drops, a mydriatic and cycloplegic drug used commonly in pediatric and ophthalmic practice.¹ The ...

To the Editor: Dr. Misbin (Oct. 31 issue)* refers to the assisted death of a patient with terminal illness as an intentional killing, and to the termination of dialysis in a patient with renal failure or the removal of a respirator from a patient who ...

To the Editor: In their reviews of Anne Sexton: A Biography by Diane Middlebrook¹ that appeared under the heading "Confidentiality in Psychotherapy — The Case of Anne Sexton" (Nov. 14 issue), both Stone² and Eisenberg³ hail the "ingenious,"² "imaginative,...

THESE four books, representative of many contemporary books on psychiatry, range from a simplified, very basic introductory textbook to one that presents a highly specialized and sophisticated nosologie system for the grouping of depressions. Each book ...

Perhaps more than any other medical therapy, the effective treatment of abnormal human behavior has excited controversy and disagreement. As is well known, even the categorization of abnormal behavior varies from culture to culture, despite intensive ...

Following their own advice on the power of metaphor, the authors of Expanding Therapeutic Possibilities begin by recounting the story of Anna and Kata, sisters and eventual therapists who have contrasting views of life and, hence, diametrically opposed ...

The tragedy of suicide, some 30,000 cases of which are certified annually in the United States, can best be understood through the words of survivors. Their experiences serve as oral histories both of the unique phenomenology of survivorhood and of the ...

Perversions, or paraphilias, as they are more commonly termed now in psychiatric literature, are among the most intriguing and disturbing of psychiatric phenomena. This book, edited by two psychoanalysts at the Columbia University Center for ...

This is a book that should be read by anyone who treats substance abusers, whether for their physical or psychological ills. The book is described on the book jacket as courageous, and it is. In the field of substance abuse, beliefs have so often been ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits. The Journal does not publish unsolicited ...

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NEUROSCIENCE OF HIV INFECTION

The 4th annual conference, subtitled "Basic and ...