DILATED cardiomyopathy is a disease of unknown cause characterized by dilation and impaired function of one or both ventricles.¹ The prevalence of dilated cardiomyopathy has been estimated to be 36.5 per 100,000 in a population-based study.²

Most cases ...

CRYPTOCOCCAL meningitis, the most common life-threatening opportunistic fungal disease in patients infected with the human immunodeficiency virus (HIV) type 1, occurs in 5 to 8 percent of patients with the acquired immunodeficiency syndrome (AIDS).^{1 2 3} ...

IMPOTENCE is a major clinical problem of adult men. In the United States alone, approximately 10 million men suffer from dysfunction of penile erection. Annually, erectile dysfunction results in more than 400,000 outpatient visits and 30,000 hospital ...

IRON overload in the absence of hyperplastic refractory anemia or blood transfusions is found in two epidemiologically important conditions: hereditary hemochromatosis and African dietary iron overload.¹ In hereditary hemochromatosis, an inborn error of ...

ALMOST all states have developed policies for the notification of sex partners of persons infected with the human immunodeficiency virus (HIV) and persons who share needles with them (needle-sharing partners), in order to target counseling, risk-reduction ...

ALMOST as soon as a therapeutically useful concentrated immune globulin product became available for intramuscular use, it was obvious that a preparation that could be administered intravenously would be advantageous.^{1 , 2} However, many years of ...

Presentation of Case

An 88-year-old woman was seen at this hospital because of a question of Huntington's disease.

The patient was well until 28 years earlier, around the time that her husband had a stroke, when she became less interested in her usual ...

IN people of Northern European descent, hereditary hemochromatosis is a common cause of iron overload. In the United States, Australia, and Europe, the frequency of the gene is approximately 5 percent, with 0.2 to 0.7 percent of the population being ...

THE trends toward empowering patients and questioning scientific expertise antedated the epidemic of the acquired immunodeficiency syndrome (AIDS). As early as the late 1960s, observers noted an increase in the involvement of patients and their advocates ...

To the Editor: In my 20-year experience working with the pharmaceutical industry, I have never been subjected to the pressures, censorship, or constraints described by Dr. Kessler (July 18 issue)* and have been given the freedom to organize symposiums, ...

To the Editor: Drs. Ransohoff and Lang (July 4 issue)¹ conclude that screening of asymptomatic persons for colorectal cancer is not justified because it has not been shown to reduce mortality. The benefit of breast-cancer screening required several ...

To the Editor: In a study of birth defects among the offspring of survivors of cancer in childhood and adolescence, Green et al. (July 18 issue) found congenital heart disease in 2 of 20 children born to eight women who received dactinomycin as part of ...

To the Editor: As the level of tolerance for lead exposure in childhood is reduced, low-dose sources of lead are being reexamined, including lead in drinking water.^{1 2 3} Despite the recent attention to water from elementary-school fountains, the largest ...

To the Editor: In recognition of data indicating that exposure to lead may have adverse effects at blood lead concentrations well below 25 μg per deciliter (1.2 μmol per liter), new guidelines from the Centers for Disease Control (CDC) lower the level ...

To the Editor: In their article on predictors of event-free survival after balloon aortic valvuloplasty (July 4 issue),¹ Kuntz et al. report their follow-up of 205 patients. They are cautiously negative in their final assessment of this procedure. We ...

To the Editor: Cost-effectiveness studies have become important in our clinical decisions because of the rising cost of medical care. The increase in cost is due in part to a marked increase in the price of new pharmaceutical agents. However, the cost-...

To the Editor: Can it be assumed from the article by Localio et al. (July 25 issue)* that in the 3570 malpractice cases filed in 1984 in New York only 280 patients were identified who had adverse events caused by medical negligence? For the other 3290 ...

This excellent translation of Santiago Ramón y Cajal's brilliant work could not have been published at a better time. One hundred years ago Cajal led a revolution in the study of the nervous system, and in this congressionally declared "decade of the ...

The elderly make up an increasingly large proportion of the population and are increasingly the focus of specialized attention in all medical disciplines. Professor Duckett has edited a multi-authored monograph (the authors are predominantly American and ...

Aesthetically, this is a beautiful, profusely illustrated atlas with approximately 750 photographs, photomicrographs, line drawings, and image reproductions. Almost all the illustrations are in color, and they are almost without exception sharply focused, ...

This is a challenging book. Let's immediately discard the obligatory review chapters (chapters 1, 2, 3, and 6), which contain basic material on stroke better presented in standard textbooks. Then let's overlook the fact that many classic neurobehavioral ...

The husband drinks steadily at the kitchen table, his blood alcohol level rising as steadily. When his wife returns, he questions her about her whereabouts, but without waiting for an answer, he strikes her to the floor with his fist. This all-too-...

As concern with exercise and personal fitness has burgeoned in contemporary America, so has the syndrome of compulsive exercise. This timely new book is a wide-ranging examination of pathologic forms of exercise and their relation to the eating disorders. ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

CALL FOR INFORMATION/HUMAN COLOSTRUM

The International Union of nutritional ...

Phenobarbital for Febrile Seizures — Effects on Intelligence and on Seizure Recurrence (February 8, 1990;322:364–9). In Table 2, the Horvitz–Thompson average should have been 97.69 for the phenobarbital group and 104.73 for the placebo group. The ...