INOSITOL is a component of membrane phospholipids,¹ and compounds containing inositol are important in signal transduction.² A deficiency of inositol^{3 4 5 6 7 8} can result from a deficiency in the diet,⁵ in intracellular uptake,^{3 4 5 , 8 , 9} or in ...

PULMONARY embolism is a potentially fatal disorder for which anticoagulation therapy improves the outcome. Untreated, clinically apparent pulmonary embolism has been associated with a 30 percent hospital mortality rate, whereas the mortality rate for ...

SINCE the first description of Kawasaki disease by one of us in 1967,¹ case reports from more than 50 countries have appeared. This febrile disease, the cause of which is unknown, primarily affects infants and toddlers, in whom it causes widespread ...

AMITRIPTYLINE reduces pain in patients with painful diabetic neuropathy or other neuropathic pain syndromes,^{1 2 3} but treatment is often compromised by the sedation, urinary retention, or orthostatic hypotension caused by the drug. It has a wide range of ...

PERIPHERAL neuropathy is an often disabling long-term complication of diabetes mellitus¹ and the most common cause of neuropathy in industrialized countries.² Its manifestations range from subclinical alteration of nerve conduction, affecting practically ...

THE treatment of atrial fibrillation and the prevention of its complications are primarily pharmacologic problems. Treatment has two principal objectives. One is to use antiarrhythmic therapy to relieve symptoms; the other is to use prophylactic therapy ...

A 43-year-old man with a long but poorly characterized psychiatric history presented to the emergency room complaining of nausea, vomiting, shortness of breath, and hearing things.

The age of the patient, the available history, and the major symptoms lead ...

Presentation of Case

A 56-year-old man with Waldenström's macroglobulinemia and severe immunodeficiency was admitted to the hospital because of multiple cutaneous vesicles and oral ulcers.

There was a two-year history of Waldenström's macroglobulinemia, ...

IN this issue of the Journal, Hallman and colleagues¹ report that inositol supplementation in premature infants with respiratory distress syndrome who were receiving parenteral nutrition improved survival without bronchopulmonary dysplasia and decreased ...

IN this issue of the Journal, two specific problems in diabetic neuropathy are addressed. Said and coworkers describe the pathologic changes in sural-nerve biopsy specimens in five atypical cases of diabetic polyneuropathy.¹ They find evidence in these ...

To the Editor: The Dutch TIA Trial Study Group (Oct. 31 issue)¹ has presented the results of a randomized, controlled study comparing the effects of two different doses of aspirin in patients with transient ischemic attacks or minor ischemic stroke. ...

To the Editor: Before beginning prophylaxis in an attempt to lower the risk of a specific threat to life and health, one should make sure that one is not increasing the risk of another such threat. It would therefore be of great interest to learn the ...

To the Editor: In their study of the feasibility of diagnosing nasopharyngeal carcinoma through the detection of Epstein–Barr virus (EBV) in tissues by means of the polymerase chain reaction (PCR), Feinmesser et al. (Jan. 2 issue)¹ found no detectable ...

To the Editor: The report by Yankner and Mesulam (Dec. 26 issue)¹ on β-amyloid and the pathogenesis of Alzheimer's disease is a timely and comprehensive presentation of the fascinating genetics and protein biochemistry of this common, devastating ...

To the Editor: In his excellent review (Nov. 21 issue),¹ Dr. Dalakas referred to a case of polymyositis that we described² as one that was "mediated by T cells expressing the γ/δ receptor, which have cytotoxic activity restricted to the MHC-I [major-...

To the Editor: We estimate that the natural blood lead concentration of humans is about 0.8 nmol per liter (0.016 μg per deciliter). This estimate is 50- to 200-fold lower than the lowest reported blood lead levels of contemporary humans in remote ...

To the Editor: Several clinical trials using recombinant human granulocyte colony-stimulating factor (G-CSF) have demonstrated that patients with severe aplastic anemia are responsive to this agent and that neutrophil counts can be increased in the ...

To the Editor: In the article on strategies for the eradication of poliomyelitis (Dec. 19 issue),* Wright et al. failed to mention Rotary International, a crucial participant in the program of eradication. Since 1985, Rotary has contributed more than $38 ...

To the Editor: Folklore has it that cutting children's nails before they are a year old turns them into thieves. Many parents who have never heard this old wives' tale bite their babies' nails because it is convenient, or because they want to avoid ...

Given the rate at which information has increased in recent years, as well as the large number of major textbooks on cancer medicine, it is a formidable task to produce a book that will be of value to "specialists and subspecialists alike in medicine, ...

There has been an explosion of scientific information in the past decade, and its impact on clinical research (and subsequently on clinical practice) has been profound. Never before have basic-science concepts been as applicable or as relevant to the ...

Like the field it describes, Biologic Therapy of Cancer demonstrates breathtaking scope and promise within a conventional paradigm of the development of antineoplastic agents, but it would have benefited from more attention to basic immunologic concepts. ...

Dr. Alan Aisenberg, the author of this concise, well-written book about lymphoma, has spent most of his career studying and caring for patients with the diseases that make up this group of cancers. This is not, as he says in the foreword, an encyclopedic ...

The editor states in the preface that this book is for practicing oncologists and that it is designed to give them answers to frequent, simple questions rather than make them consult multiple sources. The idea is a good one, and the book in general ...

This short but authoritative book is divided into a section on hematology and one on oncology; it contains 91 chapters by 136 authors. Most chapters succinctly outline therapeutic options for a given disorder encountered in the practice of hematology or ...

A challenge to all investigators dealing with cancer is to determine the factors responsible for the development of the wide variety of cancers to which humans are prone. Environmental factors such as smoking and sunlight have been strongly linked to the ...

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TREATMENT OF THE SEXUAL PROBLEMS OF ADULTS MOLESTED AS CHILDREN

The 3rd ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...