THE efficacy of zidovudine in prolonging the survival of patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex was first reported in 1987.¹ Subsequent clinical trials examined the efficacy of zidovudine in early human ...

JUVENILE rheumatoid arthritis is the most common rheumatic condition of childhood, with an annual incidence of about 1.4 cases per 10,000 children under the age of 16 years in the United States, and a prevalence of roughly 1 per 1000.^{1 , 2} Three types of ...

RETINOPATHY of prematurity is a disease affecting the blood vessels of the developing retina that occurs primarily in premature infants. It results in the formation of vascular shunts, the development of neovascular membranes, and in its more severe forms ...

CHRONIC graft-versus-host disease (GVHD) is the main late complication of allogeneic bone marrow transplantation, occurring in approximately 40 percent of patients who survive for 100 days after transplantation. If extensive chronic GVHD is not treated, ...

This endoscopic photograph was obtained in an elderly patient who had severe diarrhea after a course of perioperative antibiotic therapy. The appearance of the rectosigmoid is characteristic of this disorder, with erythematous mucosa and discrete, ...

ALTHOUGH there is debate about its geographic origin, syphilis has been clearly described since the 15th century, as has its sexual mode of transmission.¹ In the early 20th century, syphilis was a leading cause of neurologic and cardiovascular disease and ...

Presentation of Case

A 27-year-old woman was admitted to the hospital because of cervical pain that radiated to the left shoulder.

The patient was well until six weeks earlier, when she fell while skiing and landed on her back; she experienced no symptoms ...

Juvenile rheumatoid arthritis, an idiopathic inflammatory disorder, is the most common of the rheumatic diseases in children and is an important cause of disability. The diagnosis is made when a child less than 16 years of age has arthritis for at least ...

Retinopathy of prematurity was first described in 1942,¹ and during the ensuing decade it occurred predominantly in the most modern nurseries, raising the suspicion that it might be an iatrogenic disease.² By 1956 one of the first randomized, multicenter ...

Depression is one of the most common and most debilitating psychiatric disorders. It is usually recognized when patients present with clear-cut psychiatric symptoms, but many depressed patients have only physical symptoms for which no biologic cause can ...

To the Editor: I agree that some guidelines are needed on the authorship of reports of clinical trials from multiple institutions. I also am dismayed by the committee or ex officio authorship of some of these papers. I would like to comment on the ...

To the Editor: In his letter (Oct. 3 issue),¹ Dr. Sugar describes his unsubstantiated concern about letting children observe the birth of a sibling. We agree that there may be "emotional difficulties" when children are exposed to "the spectacle of events"...

To the Editor: In the study on multiple myeloma by the European Group for Bone Marrow Transplantation (Oct. 31 issue)¹ the principal component of treatment (in 81 of 90 patients) was total-body irradiation. Those involved in transplantation tend to ...

To the Editor: The clinicopathologic features of the patient described by Burg et al. (Oct. 10 issue)¹ who had a subcutaneous T-cell lymphoma simulating panniculitis are similar to those of a series of eight patients we recently described.²

A notable ...

To the Editor: Evidence is accumulating that supports a broader role for plasmapheresis in treating acute and chronic inflammatory demyelinating polyneuropathies. Dyck et al. (Nov. 21 issue)¹ have reported that plasmapheresis is efficacious in treating ...

To the Editor: The correspondence entitled "Air Bags: Trade-offs" (Nov. 21 issue)¹ calls attention to the relatively few air bag—induced injuries that have been reported. The positive benefits of air bags should also be highlighted. Recent research ...

If found in a sanitized room In a twilight zone Away from home and loved ones Amongst kindly strangers Uniformed and devoted With my heart fluttering And my breath gasping Nearly over the bridge Having been sent for And all far beyond I wish I could say ...

As scientists, we often believe that biomedical policy making follows the same rational rules that govern our research. While this may have been true in the past, contemporary decision making is no longer based solely on scientific facts. Instead, either ...

This is a book about "susceptibility policies," genetic techniques for identifying workers at high risk of disease and screening them out of hazardous employment. Professor Draper argues that such policies have become more prominent, shifting attention ...

The excitement generated by the Human Genome Project (HGP) has quickly been extended to the public domain. Part of the public-relations effort by the leaders of the project is to stimulate support for the first truly "big science" project in biology: to ...

The Aspirin Wars is an epic of Michenerian proportions. Parts I and II describe the discovery of the analgesic properties of salicylic acid, the active ingredient in an extract of white-willow bark antedating Hippocrates; the demonstration of the greater ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits. The Journal does not publish unsolicited ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

WHAT'S NEW IN GASTROINTESTINAL PATHOLOGY

The course will be offered in ...