BONE marrow transplantation is commonly used to treat cancer and aplastic anemia and is gaining a role in the treatment of genetic disorders.¹ Although many bacterial and viral infections can now be prevented, superficial and systemic fungal infections ...

TAMOXIFEN is a synthetic antiestrogen that, since its introduction for the treatment of patients with breast cancer in the early 1970s, has come to have a major role in the management of all stages of the disease.¹ More recently, tamoxifen has been proved ...

THE information available about the effects of zidovudine therapy during pregnancy on the mother and fetus is limited.^{1 , 2} As the number of women infected with the human immunodeficiency virus (HIV) increases³ and as the indications for treatment with ...

RED-CELL A and B antigens are primarily intrinsic membrane glycoproteins that become attached during erythropoiesis by specific A and B transferase enzymes.¹ A and B antigens may also be acquired by red-cell adsorption of A and B substances present in the ...

The most common of the complement deficiencies in populations of European origin is a genetic deficiency of the second component of complement (C2).¹ Rheumatologic disorders such as systemic lupus erythematosus, Henoch—Schönlein purpura, and polymyositis ...

ASTHMA is a common illness estimated to affect between 9 and 12 million persons in the United States.¹ Most patients with asthma have mild symptoms, easily controlled with outpatient care. Recent increases in morbidity and mortality associated with this ...

Presentation of Case

A newborn boy was admitted to the hospital because of respiratory distress and a "ground-glass" appearance on an x-ray film of the chest.

The child was born at 38 1/2 weeks of the first pregnancy of a mother 26 years of age whose ...

TAMOXIFEN, a nonsteroidal compound that has both antiestrogen and estrogen-agonist activity, has been used to treat women with breast cancer for nearly 20 years, and many clinical trials have documented its efficacy in the palliative care of patients with ...

WHEN the acquired immunodeficiency syndrome (AIDS) first appeared in 1981, it was considered a disease of homosexual and drug-using men. Only later did it become evident that AIDS could also strike children and women.^{1 , 2} But attention to infection with ...

CHANGES in blood type have been described in a variety of illnesses, usually acute infections or neoplasms.¹ With the advent of transplantation of bone marrow and solid organs, a growing number of unexpected immunohematologic findings have been noted, ...

To the Editor: Because Conwell and Caine quote me appositely in their Sounding Board article "Rational Suicide and the Right to Die" (Oct. 10 issue),¹ I am emboldened to comment on their remarks. They write:

The concept of rational suicide is elusive and ...

To the Editor: In the October 31 issue of the Journal, Wingard et al.* reported the results of their retrospective study of the incidence and types of fungal infections in patients who had leukemia or who had undergone bone marrow transplantation. Some ...

To the Editor: The patient described by Yamamoto et al. (Oct. 10 issue)¹ seemed to have recurrent lymphocytic meningitis rather than Mollaret's meningitis. The main characteristic of the disease described by Mollaret² in 1944 is close mimicry of a ...

To the Editor: We were intrigued by the assertions of Stein et al. (Oct. 17 issue)* regarding a peripheral site of antinociception by morphine in patients undergoing knee surgery. We are concerned, however, about whether the study's design supports its ...

To the Editor: One issue barely considered by La Puma et al. (Oct. 31 issue)* in their study of physicians who treat members of their own families is that a financial motive may prompt such an arrangement. When a physician treats family members, the ...

To the Editor: At least five hypotheses that were not discussed in the article of Phillips et al. (Oct. 17 issue)¹ could explain their results. To address the first three of them would require little or no new data collection.

(1) The "slow months" ...

To the Editor: The three branches of our federal government, acting in concert, have enacted what has become known as the "gag" rule.¹ This law and the Rust v. Sullivan decision present an ethical quandary for physicians involved in reproductive ...

The approach to the medical care of refugees has grown in sophistication during the past five years. Other books reviewed here in recent years were based on the experiences of those working with displaced persons, discussing the physical, sanitary, and ...

If violence is both immoral and impractical, as Martin Luther King once declared, then why is it so openly tolerated in American society? Adolescents, as if endowed with a skill for seizing such societal carelessness, pay an extraordinary price for our ...

The recent literature on pregnancy among adolescents documents the need for comprehensive preventive services, culturally sensitive professionals and institutions, and increased options for poor and minority teenagers. Adolescent Pregnancy in an Urban ...

The 22nd edition of the Report of the Committee on Infectious Diseases is the 6th published by the American Academy of Pediatrics since 1971; the 21st edition appeared in 1988. This comprehensive 670-page report is presented in a large, easy-to-use ...

This book gives a fascinating glimpse into the real world to scientists in the hospital or laboratory, and is perhaps even more revealing to those studying and practicing public health in developed countries. What is one to make of a world where maternal ...

These two books are bound together by the topic of human immunodeficiency virus (HIV) infection, but they have little else in common. The book edited by Sorensen et al. is a compendium of reviews by an extended network of collaborators working directly ...

The importance and complexity of AIDS have sparked considerable research at both the bench and the bedside. This, in turn, has precipitated an avalanche of publications that can easily overwhelm both casual and committed medical readers. This book is a ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits. The Journal does not publish unsolicited ...

Notices submitted jor publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

UNIVERSITY OF LIMBURG

The following courses will be offered in Maastricht, ...

Hazard of Lead in Infant Formula (January 9, 1992;326:137). In the second paragraph, at the end of the first sentence, a sixth reference should have been cited. The missing reference should have read:

6. Shannon MW. Graef JW. Lead intoxication in infancy. ...

GM-CSF and Accelerated Hemolysis (February 6, 1992;326:417). The nextto-last sentence in the second paragraph should have read, "Because of lymphomatous infiltration of the bone marrow, we decided to give her full-dose chemotherapy followed by GM-CSF (250 ...