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March 12, 1992  Vol. 326 No. 11

Original Articles
721-725

NOSOCOMIAL transmission of hepatitis B virus (HBV), though an unusual event, has been well documented. Patient-to-patient transmission of HBV through the contamination by blood of medical equipment that was not adequately sterilized or disinfected has ...

726-732

THE transmission of human immunodeficiency virus type 1 (HIV-1) by the transplantation of organs and tissues has been reported infrequently, and in most cases has involved donors whose serum had not been tested for HIV-1 antibody.1 2 3 4 5 6 7 8 9 10 11 ...

733-736
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INTRACEREBRAL and subarachnoid hemorrhages account for nearly half of all early deaths from stroke in population-based studies.1 2 3 Several community studies have included data on intracerebral and subarachnoid hemorrhages,2 3 4 5 6 7 8 9 but information ...

737-740
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MONOCLONALITY is a fundamental characteristic of neoplasia.1 2 3 4 One transformed cell gives rise to daughter cells, all of which exhibit the same genetic change that initially provided the growth advantage to the parent cell. The accumulation of further ...

741-744

DURING the past five decades, the treatment of the various forms of leishmaniasis has depended on pentavalent antimonial compounds. These compounds have considerable toxicity, are difficult to administer, and are expensive. The alternative agents, ...

Review Article
745-749

SPASTIC diplegia is a form of cerebral palsy characterized by spastic weakness exclusively or primarily of the lower extremities.1 , 2 This disorder of movement and posture is particularly important because it afflicts the majority of patients with ...

Case Records of the Massachusetts General Hospital
750-758

Presentation of Case

A 77-year-old man was admitted to the hospital because of progressive exertional dyspnea and worsening cough.

There was a history of 35 years of smoking two to three packs of cigarettes daily, a habit that he discontinued 20 years ...

Editorials
759-761

THE paper in this issue of the Journal by Sidransky and his colleagues on the clonal origin of multiple tumors of the bladder1 augments our understanding of genetic changes in the bladder during early neoplasia and has implications for other common ...

761-762

THE survival of intracellular pathogens in the host depends on their ability to avoid being killed before or after they invade mononuclear phagocytes; these cells are critical in this respect. In some circumstances the organisms are able to replicate ...

Correspondence
762-765

To the Editor: The study population of the North American Symptomatic Carotid Endarterectomy Trial (NASCET) consisted of three groups: patients with retinal transient ischemic attack or stroke (28 percent), hemispheric transient ischemic attack (38 ...

765-766

To the Editor: The study by Bouwes Bavinck and colleagues on the relation between skin cancers and HLA antigens in renal-transplant recipients (Sept. 19 issue)1 offers further support to the notion that genetic background, immunologic responses, and ...

766-768

To the Editor: The paper by Mennella and Beauchamp (Oct. 3 issue)1 entitled "The Transfer of Alcohol to Human Milk — Effects on Flavor and the Infant's Behavior" failed to consider blood ethanol concentrations in the mothers and their infants. Moreover, ...

768

To the Editor: Previous authors have described injuries to the heart resulting from penetrating wounds to the chest caused by pins or sewing needles.1 2 3 4 5 6 7 The case reported below serves as a reminder that penetrating injury due to a sewing needle ...

768-769

To the Editor: The crisis in the delivery of health care is readily apparent in the national failure to provide preventive immunizations to children in the United States. In 1990, the incidence of vaccine-preventable diseases such as measles, mumps, ...

769-770

To the Editor: As the son of two physicians and a fairly recent student (age 15) of nursery literature, I have been following with interest the correspondence regarding the nomenclature of distal appendages (Feb. 14 and Aug. 1, 1991, issues).1 , 2 The ...

770
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Weary are we, we end At the starting gates, Our refuse spread on agar plates, Arms confined... unspeaking mind, Legs... like leaden weights.

Bones resorb in disintegrating integument. Who's running this meticulously monitored experiment? Lights off and ...

Legal Issues in Medicine
770-773

SHORTLY before the beginning of Operation Desert Storm, during Desert Shield, the U.S. military sought a waiver of requirements for informed consent for the use of investigational drugs and vaccines on our troops in the Persian Gulf. The danger of ...

Occasional Notes
773-777

ONE hundred years ago, diphtheria was predicted to be "the scourge of America in the future."1 Although this prediction was realized, diphtheria has since become only a chapter in the history of American public health, and the acquired immunodeficiency ...

Book Reviews
777
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The advent of total hip arthroplasty as conceived and executed by Sir John Charnley in the 1960s marked a revolution in the management of end-stage arthritis of the hip. As evidenced by the recent publication of books devoted to the surgical management of ...

777-778

In the past 20 years, orthopedics has moved from being a medical—surgical discipline in which operative intervention was at best an alternative approach to problems of the musculoskeletal system, often viewed as the last resort, toward being a technical-...

778

Prevention of Athletic Injuries focuses on the comprehensive medical and health team responsible for providing care to athletes and athletic teams. It contains considerable information on the epidemiologic aspects of sports-related injuries, in ...

778-779

Under the editorship of Jesse B. Jupiter, 93 authors from four continents have contributed to this high-quality textbook. Its 63 chapters are grouped into sections: the introduction; wounds of the upper extremity; tendon injuries and tendon transfers; ...

779

Clinical Musculoskeletal Anatomy is a correlative textbook for health professionals in the fields of orthopedics, neurology, and sports medicine. Its organization is similar to that of many popular gross-anatomy textbooks. Thus, it opens with an ...

779-780

Although not so entitled, this 2-volume, 65-chapter book is obviously an atlas. As the author states in his introduction, the purpose of the book is "to delineate the gross and microscopic morphologic abnormalities of the nonneoplastic disease states ...

Notices
780

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

INTERNATIONAL NEUROFIBROMATOSIS SYMPOSIUM

The symposium will be held in ...

Correction
780
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Book Review of Sexually Transmitted Diseases (October 24, 1991;325:1259–60). The academic affiliation of the reviewer, David Schlossberg, was given incorrectly. Dr. Schlossberg is affiliated with the Medical College of Pennsylvania. We regret the error.