SIGMOIDOSCOPY in asymptomatic persons appears to be a highly sensitive method for the early detection of both cancer and adenomatous polyps of the distal colon and rectum. Sigmoidoscopy is also relatively costly and uncomfortable, however, and there are ...

THERE is controversy about the correct care for patients after the removal of adenomas found at sigmoidoscopy, particularly the need for regular follow-up colonoscopic examinations.^{1 , 2} Some specialists recommend that colonoscopy be performed every three ...

CONGENITAL cytomegalovirus (CMV) infection is the most common intrauterine infection, affecting from 0.4 to 2.3 percent of live-born infants.^{1 , 2} In the United States it has been estimated that 1 percent of newborns are infected prenatally with CMV; this ...

INFECTION with Mycobacterium tuberculosis is a common complication of human immunodeficiency virus (HIV) infection among groups with a high prevalence of tuberculosis.^{1 , 2} The clinical presentation of tuberculosis in HIV-infected patients differs from ...

RENAL disease develops in only a subgroup of patients with insulin-dependent diabetes mellitus.^{1 , 2} Familial factors appear to have an important role in the predisposition of these patients, as well as some patients with non-insulin-dependent diabetes, ...

IN 1992, approximately 75 percent of all patients who present with Hodgkin's disease should be cured of their disease. This result will be achieved only with the careful application of appropriate staging techniques and treatment methods.

Cell of Origin

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The step-by-step process of clinical problem-solving is the subject of this new Journal feature. Information about a real patient is presented to an expert clinician in stages (boldface type), to simulate the way such information emerges in everyday ...

Presentation of Case

A 41-year-old woman was admitted to the hospital because of a pelvic mass and bilateral hydronephrosis.

The patient was well until 19 days earlier, when she twisted her left ankle while on a cruise to the Bahamas. Immediately ...

There is controversy about the value of screening for colorectal cancers. These cancers are thought to develop by progression through a series of premalignant and early malignant phases that culminate in invasive cancer. Theoretically, screening ...

Despite numerous reports in the medical literature, physicians do not seem to recognize the enormousness of the problems caused by congenital cytomegalovirus (CMV) disease. In 1971, Weller published a landmark article in the Journal that outlined the ...

Events during the past decade have dramatically changed the nature and magnitude of the problem of tuberculosis. Much of what many physicians learned in training about this disease is no longer true. In many respects, tuberculosis has become a new entity.

To the Editor: As the benefits of antiestrogen therapy in preventing or delaying the recurrence of breast cancer continue to be documented, as Stampfer et al. (Sept. 12 issue)* have done, more and more women will receive tamoxifen or other antiestrogen ...

To the Editor: We applaud Lockwood et al. (Sept. 5 issue)¹ for their multicenter study aimed at identifying a biochemical marker for preterm labor and delivery. However, it seems that the authors may have done themselves and the readers a disservice by ...

To the Editor: The possibility of a circadian variation in the incidence of stroke, myocardial infarction, and sudden death has intrigued investigators in recent years.^{1 2 3} Although some workers have implicated the sympathetic nervous system in this ...

To the Editor: Thrombotic thrombocytopenic purpura (TTP) is a relatively rare disorder of unknown cause that is characterized by microangiopathic hemolytic anemia, thrombocytopenia with normal plasma coagulation, transient and fluctuating neurologic ...

To the Editor: In their interesting paper, Similowski and his colleagues (Sept. 26 issue)* use the change that occurs in transdiaphragmatic pressure after a maximal stimulus while the airway is blocked as a measure of the strength of the diaphragm.

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To the Editor: Rosenstock et al. are to be commended for the excellent article on the shortage of specialists in occupational and environmental medicine (Sept. 26 issue).* However, we find one of their six solutions to be troubling — namely, the ...

To the Editor: Recently, there have been several disruptions in the supply of antimycobacterial drugs, affecting stocks of capreomycin (Lilly), cycloserine (Lilly), ethionamide (Wyeth), aminosalicylate sodium (Lannett), streptomycin (Lilly and Roerig), ...

Breast Diseases is the second edition of a textbook devoted to one of medicine's most emotionally charged and intellectually challenging problems: the patient with disease in her (or rarely his) breast. Whether benign or malignant, breast disorders are ...

The Institute of Medicine has prepared an interesting publication of value to students of the controversy about the safety of oral contraceptives and those who desire a concise summary of existing epidemiologic data. The book includes an introduction, ...

The large number of variables involved in an accidental injury of the eye and the multitude of available treatments make the choice of optimal therapy difficult. Anecdotal experience plays an important part in determining how traumatic eye and orbital ...

This small color atlas reviews the preoperative assessment of patients with cataracts and the anesthetic and operative care of patients undergoing cataract surgery. It also reviews the techniques of phacoemulsification, planned extracapsular extraction of ...

The Atlas of Bronchoscopy is an illustrative synopsis of conditions diagnosed with the use of the fiberoptic bronchoscope. It is more than an atlas of bronchoscopy, however, in that correlative radiologic and pathological material is also shown for the ...

This new textbook should be welcomed by gynecologists and urologists alike. Its publication led me to wonder whether urogynecologists and urologists who treat girls and women actually represent a single specialty spontaneously evolved from separate ...

Despite its subtitle, this multiauthored book is not a soup-to-nuts treatment guide but a collection of 29 chapters on a variety of topics related to patients with spinal-cord injury. The book is graphically well executed, uniformly well written, and easy ...

The field of spinal surgery has undergone a rapid evolution and expansion in the past 10 years, particularly as a result of the development of new instruments and techniques for reducing deformity and stabilizing the spine. Aside from a better ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

INTERNATIONAL INTRADISCAL THERAPY SOCIETY

The 5th annual meeting will be held ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...