Malnourished surgical patients are at greater risk for postoperative morbidity and mortality than well-nourished patients undergoing similar operations for similar indications.¹ Studies attempting to define the effect of preoperative nutritional support, ...

THE pathogenesis of lung disease induced by cystic fibrosis reflects in part the effects of mutations in the cystic fibrosis transmembrane regulator protein on electrolyte transport by airway epithelia.¹ Both the defective regulation of the secretory ...

SPIROCHETES are among the most common bacteria found in subgingival plaque associated with periodontal diseases, but many species that have been observed directly have not been isolated, cultivated, or characterized.¹ Patients with acute necrotizing ...

RENAL transplantation corrects many of the disturbances of calcium and phosphorus metabolism that lead to renal osteodystrophy in patients with chronic renal insufficiency. The increase in glomerular filtration corrects the retention of phosphorus and ...

INFECTIONS with acyclovir-resistant herpes simplex virus in patients with human immunodeficiency virus (HIV) infection may progress inexorably if untreated, becoming a source of severe pain, disfigurement, and bacterial superinfection.^{1 2 3 4 5 6 7 8 9} In ...

OVER the past two decades, percutaneous transluminal angioplasty has emerged as a popular alternative to peripheral bypass surgery for many patients with peripheral vascular disease of the lower extremities.^{1 2 3 4} Advocates of angioplasty contend that, ...

Presentation of Case

A 51-year-old man was admitted to the hospital because of severe hypertension and increasing renal failure.

There was a five-year history of mild, labile hypertension that was treated for three months with hydrochlorothiazide—...

The belief that hospitalized patients will benefit from parenteral nutritional support is based on a body of indirect evidence. Malnutrition is common among hospitalized patients, particularly those whose ability to digest and absorb oral or enterally ...

The highest goal of biomedical bench research is to translate test-tube discoveries into real-world benefits for patients. The extraordinary advances in research on cystic fibrosis in the past 10 years have provided a wealth of opportunities for ...

Severe peripheral vascular disease is a common disorder that frequently creates substantial morbidity in our aging population. A nonsurgical approach to the treatment of intermittent claudication, one of the chief manifestations of the disease, was widely ...

Disposal of medical waste has emerged as a major problem in the United States. The problem was brought to public attention by recent episodes of medical waste washing ashore in some coastal states and the perceived threat of contracting the acquired ...

To the Editor: During the recent Persian Gulf war, there were 18 missile attacks from western Iraq on scattered areas in Israel. The fear of chemical warheads resulted in the preventive use of gas masks by the Israeli population for variable periods ...

To the Editor: Dr. Kern's report (March 28 issue)* of an elderly man with normal cholesterol levels who eats more than two dozen eggs a day is interesting, especially to those of us with an interest in cholesterol metabolism. I do, however, note that the ...

To the Editor: The investigators of the Cardiac Arrhythmia Suppression Trial (CAST) (March 21 issue)¹ found an excess of deaths due to arrhythmia and deaths due to shock after acute myocardial infarction in patients treated with encainide or flecainide. ...

To the Editor: Chapman et al. (March 21 issue)¹ have performed a well-controlled study validating the current practice of outpatient steroid use after emergency room treatment of exacerbations of asthma. However, given a relatively convincing previous ...

To the Editor: Oxygen-derived free radicals are highly chemically reactive species capable of widespread indiscriminate tissue injury in biologic systems. Increased systemic production of free radicals is known to be a feature of several inflammatory ...

To the Editor: Anaphylactic reactions have occurred after the administration of many different immunogens, including antiserums, hormones, enzymes, venoms, diagnostic agents, and drugs. We describe a patient who had an acute anaphylactic reaction during ...

To the Editor: The case presented by Hohlfeld et al. (March 28 issue)¹ of a patient with polymyositis is very interesting and unique with regard to the immunopathological findings in the biopsy specimens. The authors were convinced that the γ/δ T cells ...

To the Editor: A 77-year-old woman with chronic renal failure, glaucoma, and a history of mild dementia was hospitalized for evaluation and treatment of volume excess, metabolic acidosis, electrolyte abnormalities, and changes in mental status. Her usual ...

In rescuing this important and delightful manuscript, Dr. D. Lynn Loriaux has done a great service for those of us in the field of endocrinology and clinical investigation, as well as for a broader audience, who will enjoy the manner in which one of the ...

This important book, a collection of essays from a literature symposium held in 1989, is a scholarly effort to deal with the literary treatment of medical themes and the place of literary training in medical education. Fifteen authors, all highly ...

Dr. William Carlos Williams said it best:

... and my "medicine" was the thing which gained me entrance to these secret gardens of the self. It lay there, another world, in the self. I was permitted by my medical badge to follow the poor, defeated body ...

Illness just happens. Sure, we can reduce our risks, try to avoid accidents, and think healthy thoughts, but most of us will eventually get sick anyway. For many, the inevitability of illness is difficult to accept. For Arthur Frank, acceptance is the key ...

Take a professor of English who is a prize-winning journalist, give him free rein in one of the foremost pediatric institutions in this country, and what do you get? A welcome and poignant account of the intense human and political dynamics of a major ...

Little is generally known about the phenomenon of medical-malpractice suits in the United States before World War II. This well-written and superbly documented book, written by a professional historian at Rice University, fills the void quite well for the ...

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TECHNOLOGY MANAGEMENT GROUP

The following conferences will take place: "Oral ...