CAROTID endarterectomy was introduced in 1954 as a logical procedure for the prevention of ischemic stroke distal to carotid-artery stenosis.¹ Although the first randomized trials of its effectiveness had negative results,^{2 3 4} surgeons continued to ...

LIVER disease is an important cause of morbidity J and mortality in renal-transplant recipients, with abnormalities of liver function occurring in 7 to 24 percent of patients early in follow-up^{1 , 2} and death due to liver failure in 8 to 28 percent of the ...

SUSTAINED weight loss in moderately overweight men, whether induced by caloric restriction (with no change in dietary composition) without increased physical activity, or by increased physical activity without dietary change, results in an increase in ...

MULTIPLE sclerosis, an inflammatory and demyelinating disease of the central nervous system, is regarded as a major cause of neurologic disability among young adults.¹ The disease follows a chronic, recurrent course and is associated with well-established ...

Increased activity of the γ-aminobutyric acid [GABA] neurotransmitter (GABA-ergic) system may have a fundamental role in the pathogenesis of hepatic encephalopathy,^{1 , 2} a complex neuropsychiatrie disorder that complicates acute or chronic liver failure.³ ...

TRENDS in adoption have changed remarkably since the Journal last reviewed this issue more than 30 years ago.¹ Because numerous social and demographic circumstances have limited the availability of U.S.-born babies for adoption, an increasing number of ...

DANGEROUS aquatic animals can be divided into four groups: those that bite, those that sting (envenom), those that are poisonous if eaten, and those that can deliver an electric shock. This discussion focuses on the treatment of victims of marine ...

Presentation of Case

A 74-year-old man was admitted to the hospital because of a question of acute ischemic optic neuropathy.

There was a history of atherosclerotic peripheral vascular disease of many years' duration. A myocardial infarct occurred more ...

Atherosclerotic narrowing at the bifurcation of the common carotid artery is by far the most common cause of large-vessel atherothrombotic stroke. Atherosclerotic plaque tends to form in the posterior part of the bifurcation, at the origin of the internal ...

Pereira et al.¹ report in this issue of the Journal on the high morbidity associated with the transplantation of organs from 13 cadaver donors who were positive for antibodies against the hepatitis C virus (HCV). This study of 716 donors from the New ...

The report of Basile and his colleagues in this issue of the Journal illustrates some recent trends in research on hepatic encephalopathy.¹ First, more work is being performed with collaboration by several disciplines. This paper, for instance, features ...

Helga Wanglie, an 86-year-old Minneapolis woman, died of sepsis on July 4 after being in a persistent vegetative state for over a year. She was the focus of an extremely important controversy over the right to die that culminated in a court decision just ...

An 85-year-old woman was taken from a nursing home to Hennepin County Medical Center on January 1, 1990, for emergency treatment of dyspnea from chronic bronchiectasis. The patient, Mrs. Helga Wanglie, required emergency intubation and was placed on a ...

To the Editor: As one of the victims of the outbreak of scombroid-fish poisoning reported by Morrow et al. (March 14 issue),* and with pride in the extremely high level of histamine excretion I was able to achieve, I would like to provide some additional ...

To the Editor: I came across the interesting article by Williamson et al. (March 4 issue)* because I work for a health maintenance organization that subscribes to the Journal.

I am a perfect example of the findings of this research. I have quit smoking ...

To the Editor: In reference to Drs. Baldessarini and Frankenburg's review article (March 14 issue),¹ we are writing to inform you of a potentially lethal side effect of clozapine.

A 47-year-old woman with a diagnosis of chronic paranoid schizophrenia, ...

To the Editor: Krook et al. (March 14 issue)¹ report the effects of postoperative radiation combined with fluorouracil and semustine for rectal carcinoma. The rate of recurrence was strikingly high in both arms of their study: 61 percent in patients ...

To the Editor: We were disappointed to observe an omission from the article by Conn and Crowley (Jan. 10 issue) on analogues of gonadotropin-releasing hormone (GnRH). Despite having the largest clinical-trial data base of any of the analogues, goserelin (...

To the Editor: Ciprofloxacin, a fluoroquinolone, is widely used for a broad range of infections.¹ Although it has had some success in treating respiratory tract infections, delayed clinical responses and the failure to eradicate pathogens from sputum ...

To the Editor: Etretinate is a retinoid that is used to manage recalcitrant psoriasis. We recently cared for a patient in whom a curious symptom developed while he was taking 75 mg of etretinate daily to control severe psoriasis. He noted an annoying ...

To the Editor: We recently treated a "two-fathom hickey," an entity not previously described in the medical literature.

A 37-year-old woman scuba diving in 12 feet of water near the Cayman Islands was hand-feeding stingrays that were 3 to 5 feet long. ...

Early applications of magnetic resonance imaging (MRI) were predominantly centered around disease processes and anatomical regions that had previously been imaged successfully with CT. In the late 1980s it became increasingly clear that MRI was capable of ...

Although of recent vintage as a diagnostic device, magnetic resonance imaging (MRI) has already become the preferred method of imaging for several organ systems, including the pelvis and joints. Far and away the most useful applications have been in ...

This book consists of 44 chapters devoted to the use of diagnostic sonography in obstetrics and gynecology. Most of the book (31 chapters) concerns obstetrics, with the primary emphasis being placed on gynecology in 7 chapters, on breast sonography in 1, ...

This book, one in a three-volume set that encompasses most of the organ systems evaluated by sonography, is concerned with the expanding field of sonography in obstetrics and gynecology. Fifty-eight authors, including primarily sonographers (nonphysicians ...

There is clear need for a textbook updating the use of sonography in children. In part, this book fulfills that need.

The references at the end of each chapter and the quality of the sonograms are the book's strongest aspects. The figures, notations, and ...

This book is widely known and has become one of the standard skeletal-radiology textbooks since the first edition appeared in 1967. Additions and revisions dictated by medical advances led to new editions in 1973 and 1981, and to the current fourth ...

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CALL FOR PARTICIPANTS

Patients between the ages of 12 and 65 with idiopathic or ...

Linkage of a Gene Causing Familial Amyotrophic Lateral Sclerosis to Chromosome 21 and Evidence of Genetic-Locus Heterogeneity (May 16, 1991; 324:1381–4). On page 1381, in the opening paragraph of the article, third line, "Charcot's syndrome" should have ...