CARDIOGENIC pulmonary edema is a common clinical problem in most hospitals. Despite the use of supplemental oxygen and the administration of drugs to decrease lung water and improve myocardial performance, many patients have severe respiratory failure. ...

THE ataxia—telangiectasia gene predisposes those carrying it to cancer; homozygotes, who have a distinctive neurologic disorder and oculocutaneous telangiectasia, have a risk of cancer 61 to 184 times higher than that in the general population.¹ ...

PERSONS with human immunodeficiency virus (HIV) infection have elevated rates of disease caused by the encapsulated bacteria Streptococcus pneumonias and Haemophilus influenzae} ^{1 2 3 4 5 6 7 8 9 10 11 12 13 14} The annual incidence rate for H. influenzae ...

X-LINKED hypophosphatemic rickets involves two defects, impaired proximal tubular reabsorption of phosphate and a relative deficiency of 1,25-dihydroxyvitamin D production.¹ The clinical manifestations include growth failure, bowing of the legs, ...

THE term "hibernating myocardium" was coined by Rahimtoola¹ to describe persistent cardiac dysfunction due to chronic ischemia that is at least partially reversible if the severity of ischemia is reduced. Myocardial hibernation has most often been ...

IN adults, deficiency of carnitine palmitoyltransferase (CPT) II is a genetic disorder characterized by exercise intolerance and myoglobinuria.^{1 , 2} In newborns, it is a generalized, lethal disease with reduced CPT II activity in multiple organs, reduced ...

SIXTY to 80 percent of cases of dementia among persons over the age of 65 are caused by Alzheimer's disease. Most of the remainder are caused by cerebrovascular disease with multiple infarcts, and a smaller proportion are due to tumors, infections (e.g., ...

Presentation of Case

An eight-year-old girl with Hirschsprung's disease was admitted to the hospital because of recurrent abdominal pain, with abdominal distention and diarrhea.

The patient was born of a full-term first pregnancy to a mother 24 years of ...

Appropriate environmental measures and the wide use of vitamin D have led to the nearly complete disappearance of common rickets in most developed countries (with the exception of those few that have yet to begin fortifying milk). In other parts of the ...

Less than 20 years ago, contractile dysfunction of the myocardium in patients with coronary-artery narrowing was thought to be caused by either irreversible damage to myocytes (that is, myocardial infarction or scarring) or reversible ischemia (such as ...

Do-not-resuscitate (DNR) orders have been implemented in every setting in the hospital during the past two decades. Because of ethical concern about the inappropriate application of cardiopulmonary resuscitation (CPR),^{1 , 2} their use has spread from the ...

To the Editor: In their excellent article on tuberculosis in patients with human immunodeficiency virus (HIV) infection (June 6 issue), Barnes et al.¹ mention but do not emphasize a point that adds greatly to the urgency of controlling the spread of ...

To the Editor: The article by Smith and colleagues (July 4 issue)¹ on their trial of ribavirin in infants receiving mechanical ventilation for severe respiratory syncytial virus (RSV) infection has a major problem in study design that many readers may ...

To the Editor: We conclude from the article by Szer et al. (July 18 issue)* that antibiotics play little part in what are presumed to be late manifestations of Lyme disease. This raises a question about a pattern of practice in Westchester County, New ...

To the Editor: The most commonly used serologic test for diagnosing Lyme disease is the enzyme-linked immunosorbent assay (ELISA), which can detect IgM and IgG antibodies to Borrelia burgdorferi. ¹ False positive results with ELISA may occur as a ...

To the Editor: Helmrich et al. (July 18 issue)¹ suggested that non-insulin-dependent diabetes mellitus (NIDDM) can be prevented by increased physical activity. Although interesting, we believe this conclusion is premature. Even though the reported ...

To the Editor: In the June 14, 1990, issue of the Journal, Takasu et al. described three patients who had thyroid dysfunction after unilateral adrenalectomy for Cushing's syndrome due to an adrenal adenoma.¹ We wish to call your attention to the fact ...

To the Editor: Dr. Begue et al., in discussing the association between infections caused by Streptococcus pneumoniae and the hemolytic uremic syndrome (July 11 issue),* state that during the past 10 years, 21 cases of hemolytic uremic syndrome were ...

To the Editor: Patients with the Chiari type I malformation may have severe episodic headaches associated with increases in intraabdominal or intrathoracic pressure.¹ We report the occurrence of these headaches in a 15-year-old high school student. He ...

One would expect Comprehensive Neurology, a textbook designed and priced for the advanced user, to have special features that would separate it from other, less expensive products. It contains detailed, scholarly accounts that provide a sophisticated ...

The editors of this lengthy textbook of neurology intended it to concentrate on clinical problems and to describe syndromes and disorders in depth, rather than to emphasize recent advances. The result is an extremely useful clinical compendium.

The ...

Although many of the basic principles of child neurology have remained the same over the past few decades, there have been numerous recent clinically important advances in the diagnosis and management of neurologic disorders in children. Essentials of ...

The second edition of Developmental Neurobiology was published in 1978. Since then, the field of developmental neuroscience has expanded enormously. Molecular biologic techniques have accelerated the discovery of trophic factors that have key roles in the ...

Considering its scope, Inpatient Psychiatry provides a remarkably up-to-date review of the hospital practice of psychiatry. Nowadays, the appropriate care of hospitalized psychiatric patients is exceedingly complex. This book reflects the depth and ...

Evaluation of the Psychiatric Patient is a pragmatic, clear, and readable book in which author Seymour L. Halleck brings his wisdom born of experience to the beginner. His approach is skillful and sensitive and should be enormously helpful to psychiatric ...

In many ways the treatment of depression parallels that of infectious disease. An array of broad-spectrum medications are available, and a positive clinical response is usually predictable, though relapse may occur if the drug of choice is not continued ...

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TRANSFUSION MEDICINE 1992

The program will take place in Arlington, Va., and ...