THE fragile X syndrome is the most common cause of inherited mental retardation and one of the most frequent genetic diseases. It is estimated to cause one case of mental retardation in every 1000 to 1500 males and one case of generally milder mental ...

ETOPOSIDE and teniposide, two semisynthetic derivatives of podophyllotoxin, have a broad range of antineoplastic activity and have been used widely in the treatment of children and adults with malignant diseases.^{1 , 2} Reports appearing over the past four ...

THE McCune–Albright syndrome, a disease of unknown cause, is characterized by polyostotic fibrous dysplasia, café au lait pigmentation of the skin, and multiple endocrinopathies, including sexual precocity, hyperthyroidism, pituitary adenomas secreting ...

AN increasing body of data from large, multicenter, randomized trials now indicates that in small premature infants both prophylactic and therapeutic ("rescue") administration of surfactant saves lives.^{1 2 3 4 5 6 7} The effects of surfactant replacement ...

WHAT happens when there is a profound change in the traditional diet of a culture, from a customary low-fat diet of largely unprocessed plant foods to an "affluent" diet containing the high-fat and low-fiber foods produced by modern food technology? This ...

FRAGILE X syndrome is the most common form of familial mental retardation.¹ Its prenatal diagnosis has relied on cytogenetic detection of the fragile X chromosome in cultured amniotic fluid, chorionic-villus cells, or fetal blood obtained by ...

OVER a century ago, in a classic paper, Samuel Gee¹ provided a thorough description of the clinical features of childhood celiac sprue. However, subsequent truly seminal observations regarding celiac sprue awaited the 15 years that followed World War II. ...

Presentation of Case

A 71-year-old woman was admitted to the hospital because of gradual progression of marked weakness of the lower extremities.

The patient was well and vigorously active until eight months earlier, when she experienced the onset of ...

The clinical picture of the X-linked form of mental retardation associated with a fragile X chromosome was first elucidated in 1980. The affected males are retarded and have long, thin faces with prominent jaws, large and protuberant ears, macroorchidism, ...

In 1937, McCune and Bruch¹ and Albright and associates² separately described an unusual syndrome characterized by polyostotic fibrous dysplasia, café au lait pigmentation, and in female patients, endocrine dysfunction with precocious puberty. Subsequent ...

In the report by McMurry et al. in this issue of the Journal,¹ native Mexicans who traditionally consume little fat were given a diet that, even by U.S. standards, was high in animal fat. Serum total cholesterol levels rose, but so did those of high-...

To the Editor: The article by Greenblatt et al. (June 13 issue)¹ describes memory impairment induced by triazolam in both young and elderly subjects. The accompanying editorial by Gillin² cautions about the potential hazards of benzodiazepine use in the ...

To the Editor: The report by Lissner et al. (June 27 issue)¹ on the variability of body weight and health outcomes in the Framingham population is an important contribution to the debate about the health consequences of the cycle of weight loss and ...

To the Editor: In the evaluation of blood donations for the presence of human immunodeficiency virus type 1 (HIV-1) by Busch et al. (July 4 issue),¹ the conclusion appears to be at odds with the data. The concluding sentence of the abstract states that "...

To the Editor: We agree with the basic message of Platt et al. (July 4 issue)¹ that longitudinal follow-up of painful episodes in patients with sickle cell syndromes generates new insights into certain aspects of these disorders. We wish, however, to ...

To the Editor: The news report of an ABO-incompatible heart transplantation¹ should be added to those of eight previous transplantations with similar fates. Since there have been about 10,000 heart transplantations performed in the United States to date, ...

To the Editor: The use of microwave ovens for cooking is now universal. However, cooking certain foods can be hazardous. We report two cases of ocular injury caused by cooking eggs in a microwave oven.

A 21-year-old woman cracked an egg into a dish and ...

The most notable changes in this new edition of Current Obstetric and Gynecologic Diagnosis and Treatment are in its organization. It now consists of seven sections covering the basic science of reproduction, normal obstetrics, high-risk obstetrics, ...

This book, now in its third edition in 12 years, has become something of a classic in its field. Almost all the contributors and editors are on the faculty of the University of Southern California School of Medicine, and the book reflects a productive ...

Dr. Taymor has succeeded in meeting the challenge of writing a textbook on the evaluation of male and female infertility. With the exception of one chapter — "Infertility Counseling" — that he coauthored with Ellen Bresnick, M.S.W., Dr. Taymor has written ...

The first edition of this book was published five years ago, when the subspecialty of gynecologic oncology was being established in the United Kingdom. There are now five recognized units approved in that country for the training of fellows in gynecologic ...

Blackledge and Jordan (both from the United Kingdom) and Shingleton (from the United States) have attempted to "give a balanced view of gynecological cancer across the western world," and they have succeeded royally. Although their book is directed at ...

The maturation of any medical specialty is often reflected in the number of textbooks devoted to its explication. The maturation of critical care medicine has been accompanied by the publication and revision of numerous books. The earlier (and larger) ...

This is the first edition of a uniquely formatted textbook on emergency medicine, which is organized and nicely cross-referenced for the practicing emergency physician. It should be an especially welcome addition to a field as broad and sometimes as ...

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UNIVERSITY OF CHICAGO SCHOOL OF MEDICINE

The following courses will be ...