NONSTEROIDAL antiinflammatory drugs (NSAIDs), such as aspirin, indomethacin, piroxicam, and sulindac, inhibit the growth of colon tumors induced by chemical carcinogens in rodents.^{1 2 3 4 5 6 7 8 9 10 11 12 13} The mechanism is unknown, but it may involve ...

THE prevalence of osteoporosis and the incidence of vertebral fractures are both substantially lower in black than in white women, a finding generally attributed to racial differences in adult bone mass.^{1 2 3} Although bone density is greater in black than ...

CYTOMEGALOVIRUS (CMV) infection remains a formidable barrier to allogeneic bone marrow transplantation and continues to cause morbidity and mortality among recipients who are immunocompromised for other reasons.^{1 2 3} Patients who excrete CMV after ...

MULTIDRUG resistance in chemotherapy for cancer is characterized by increased expression of P-glycoprotein, a conserved 170-kd plasma membrane protein homologous to bacterial-transport proteins.^{1 , 2} P-glycoprotein is thought to cause cross-resistance to ...

CYSTIC fibrosis is the most common fatal recessive disease in whites. In the past the diagnosis has been based on the presence of lung disease, pancreatic exocrine insufficiency, and increased sweat electrolyte concentrations.¹ Patients with cystic ...

BY any measure, firearms — especially handguns — are a leading instrument of violent injury. In 1987, firearms accounted for 32,919 fatalities in the United States: 18,144 suicides, 12,665 homicides, and 2110 unintentional fatalities, legal interventions (...

ADENOSINE is an endogenous nucleoside that is capable of causing atrioventricular nodal conduction block in humans.¹ Although the use of intravenous adenosine to terminate supraventricular arrhythmias was first described in 1933,² it is only in the past 8 ...

Presentation of Case

A 46-year-old man was admitted to the hospital because of leg swelling and a mass in the popliteal fossa.

The patient was well until eight months earlier, when he fell while skiing and forced his right knee into a position of full ...

IN the United States, tumors of the colon and rectum account for approximately 15 percent of all visceral cancers and about 12 percent of all deaths from cancer. During the past several decades, the incidence of these cancers has remained relatively ...

A person's maximal bone density — termed the peak bone mass — is usually achieved in the third decade of life; thereafter, bone is inexorably lost. Many of the unanswered questions that currently limit our understanding of osteoporosis concern the gain ...

FIREARMS and their grisly consequences are so pervasive in our society that they seem to be standard fare. Each day newspapers in major cities report injuries and deaths from guns, frequently among teenagers, and show photographs of their bereaved ...

WE live at a time when consumers and patients want to know more about the food they consume and the drugs they take, and their appetite for information is growing. Yet the nation is also facing a communications gap that has serious implications for the ...

DEATHS

Ames — Melvin Francis Ames, M.D., of Newburyport, died on October 24 at the age of 87.

Dr. Ames received his degree from Hahnemann Medical College of Philadelphia in 1931. He was a member of the American Medical Association and the American Academy ...

To the Editor: In their comprehensive review of the differences and similarities between nonsteroidal antiinflammatory drugs (NSAIDs) (June 13 issue),¹ Brooks and Day comment on the renal side effects of NSAIDs. We would like to draw further attention to ...

To the Editor: The article by Odio et al. on dexamethasone in children with bacterial meningitis (May 30 issue)* suggests, if I read it correctly, that 16 patients in the group presented in coma and that at least some of them had papilledema, pupil ...

To the Editor: Abnormal genital bleeding has a myriad of potential causes. However, the recent review article by Cowan and Morrison (June 13 issue)¹ on this topic did not mention the contribution of sexually transmitted infections, including cervicitis ...

To the Editor: The Veterans Affairs Laryngeal Cancer Study Group has shown beyond question that chemotherapy has a role in the primary treatment of head and neck carcinoma (June 13 issue).¹ Skeptics will argue that until a study definitively compares ...

To the Editor: The recent study of prophylactic sclerotherapy by Gregory et al. (June 20 issue) ¹ showed an unexpectedly high mortality rate in the treated group (32.2 percent, as compared with 17.4 percent in the control group). Child's score and ...

To the Editor: Corticosteroids are an important part of immunosuppressive maintenance therapy after orthotopic liver transplantation,^{1 2 3 4 5} despite their many side effects. Alternate-day administration is effective and decreases the frequency of side ...

To the Editor: Outbreaks of hepatitis E (enterically transmitted non-A, non-B hepatitis) have been reported from Burma, Somalia, the Soviet Union, Africa, Algeria, and Mexico,¹ and travelers to these parts of the world are at risk of acquiring hepatitis ...

To the Editor: In the course of a statistical review by the Food and Drug Administration of our study of GM-1 ganglioside for spinal-cord injury (June 27 issue),* Jonathan Levine identified an error in the presentation of American Spinal Injury ...

To the Editor: We wish to call attention to a needless environmental hazard from a commercial source. In his review of glucose-6-phosphate dehydrogenase deficiency (Jan. 17 issue),¹ Beutler pointed out that infection is a more common precipitating factor ...

The 1989 German textbook Interventionelle Computertomographie, now available in English, is unique in concept and content. While there are many books on computed tomography (CT) and interventional radiology, to my knowledge only Interventional Computed ...

It is generally acknowledged that the majority of radiologists and residents in radiology do not study physics out of any great interest or desire, but because the American College of Radiology requires them to pass an examination in this subject. It is ...

This sizable book, containing more than 800 pages, lives up to its title; it offers in its two major sections a comprehensive description of the available methods of in vivo cardiac imaging and their practical application to clinical medicine. The ...

This is the second edition of a book originally entitled The Heart: Physiology, Metabolism, Pharmacology and Therapy, which was published by Grune and Stratton in 1984, with a "revised reprint" appearing in 1986. In this edition, the material on ...

Grant's Atlas of Anatomy has enjoyed nearly 50 years of success as one of the most valuable student resources for anatomical dissection and study. The latest edition (the ninth) by Dr. Agur should continue this tradition, since it retains the basic ...

The second edition of Malignant Skin Tumours, edited by Drs. Emmett and O'Rourke, is a multifaceted examination of skin cancers, with sections on their clinical and pathological features, biologic basis, and therapy. This multiauthored textbook relies ...

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SOUTH-EASTERN ORGAN PROCUREMENT FOUNDATION

The tri-annual meeting will take ...

Effect of Strict Glycemic Control on Renal Hemodynamic Response to Amino Acids and Renal Enlargement in Insulin-Dependent Diabetes Mellitus (June 6, 1991;324:1626–32). On page 1629, in Table 1, the units for the plasma amino acid concentrations should ...

Book Review of Introduction to Medical Procedures: Venous and Arterial Punctures (September 5, 1991;325:745). The names of two of the three authors of the review were omitted: Jonathan Bogan and Camilo Martinez.

What Drives Neonatal Screening Programs? (September 12, 1991;325:802–4). On page 803, in the left-hand column, beginning in the fourth line, the text should have read "... and the absence of public pressure are responsible," not negotiable, as printed. We ...

Breast-Feeding in 1991 (October 3, 1991;325:1036–8). On page 1037, in the left-hand column, next to last line, the word "sucrose" should have been "lactose."

ON December 1, 1991, the Patient Self-Determination Act of 1990 (PSDA)¹ went into effect. This is the first federal statute to focus on advance directives and the right of adults to refuse life-sustaining treatment. The law applies to all health care ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...