HIGH-dose ablative therapy with rescue of bone marrow function by autologous bone marrow transplantation has become widely used in patients with hematologic and solid tumors.^{1 2 3 4 5 6 7 8 9 10} Although the infusion of autologous marrow provides ...

THE investigational hydroxynaphthoquinone compound 566C80 is active against Toxoplasma gondii, plasmodium species, and Pneumocystis carinii in vitro and in animal models.^{1 2 3} In corticosteroid-treated rats with acute pneumocystis pneumonia, 566C80 is at ...

CHICKENPOX, the primary infection caused by varicella–zoster virus, usually occurs in early childhood and is characterized by an acute illness of papulovesicular rash, fever, malaise, anorexia, and lethargy. Approximately 3.5 million cases of chickenpox ...

THE Oka strain of live attenuated varicella vaccine has been under evaluation for licensure in the United States for more than 10 years. Numerous studies have indicated that the vaccine is safe, immunogenic, and highly protective against severe varicella ...

MENTAL stress is known to precipitate angina and myocardial ischemia in patients with coronary artery disease both during laboratory testing and in daily life.^{1 2 3} The mechanisms underlying the cardiovascular reactions to acute mental stress are ...

PROTEIN C is a vitamin K—dependent glycoprotein circulating in plasma as an inactive zymogen.¹ It is converted to the serine protease—activated protein C, a natural anticoagulant that inactivates factors V and VIII after they are activated by thrombin ...

Jeffrey S. Flier, M.D., Editor Lisa H. Underhill, Assistant Editor So that the coming together depends on the going apart; the systole depends on the diastole; the flow depends on the ebb. — D.H. Lawrence

The terms "heart failure" and "congestive heart ...

Presentation of Case

A 75-year-old man was admitted to the hospital because of the recent onset of congestive heart failure and the finding of a left atrial mass. The patient was well until three or four weeks earlier, when he began to experience ...

CHICKENPOX (varicella) is a much less serious illness than poliomyelitis, diphtheria, or pertussis. Thus, one would not expect a chickenpox vaccine to reduce morbidity and mortality to the same extent as immunization against these other diseases. ...

RESEARCH often proceeds in waves produced by observations that open new avenues for investigation. Over the past decade the finding that vascular tone can be modulated by vasoactive substances released by endothelium¹ has influenced biologic, physiologic, ...

To the Editor: In their article "Physicians and the Animal-Rights Movement" (June 6 issue), Pardes et al. vigorously and uncritically defend experimentation in animals.¹ Such blanket approval of this research method is unjustified. Data from ...

To the Editor: Black observes that most radiation oncologists use craniospinal-axis irradiation to treat ependymomas of the posterior fossa (May 23 and 30 issues).¹ Although this has traditionally been the most common therapeutic approach, we have ...

To the Editor: Dr. Hirsh is to be warmly congratulated on his authoritative review (May 30 issue)1 of heparin therapy. However, I would like to make two observations.

First, there is a minor error in the section on the treatment of thromboembolism. In ...

To the Editor: In a study examining the relation of smoking to mortality among older men and women, LaCroix et al. (June 6 issue)¹ presented data on the risk of death from cardiovascular disease, coronary heart disease, and smoking-related cancer, based ...

To the Editor: The likelihood of injury related to a car crash, a leading cause of disability, death, and health care expenditures,¹ can be greatly reduced by the use of seat belts.² To assess the prevalence of seat-belt use after the implementation of ...

To the Editor: The most common mechanism of injury to the brachial plexus in infants is traction. Compression injuries are far less commonly reported. The causes of such compression injuries to the brachial plexus include the use of knapsack or backpack ...

In 1938 Cushing (with Eisenhardt) wrote a book entitled The Meningiomas (Springfield, Ill.: Charles C Thomas), the name he had given these tumors in 1922. This masterly capstone of his brilliant career was so comprehensive that no group of neurosurgeons, ...

Neuroanatomy presents a unique challenge to the beginning student. The wealth of seemingly unrelated detail to be mastered in the brief time the curriculum allows often leads students to accept on faith the instructor's assurances that "it will all come ...

Adolescent suicide frustrates primary care providers, therapists, researchers, and communities. Suicide is a leading cause of mortality in youth. Although there is only one completed suicide for every 8000 adolescents, from 1 in 15 to 1 in 7 teenagers ...

Panic disorder, a disabling and painful type of anxiety, affects between 1 and 2 percent of patients in primary care settings. Despite the frequency of panic disorder, its diagnosis is problematic because the presenting symptoms often masquerade as those ...

Ongoing upheavals in cellular biology and immunology potentially render a textbook on bronchoalveolar lavage outdated before the ink of the first edition is dry — in effect, the authors have undertaken to capture medical lightning in a bottle. Nonetheless,...

This timely book is a collection of 16 review papers from a symposium held in honor of Dr. D.H. Solomon in late 1988 in Long Beach, California. With a few exceptions the contributors are his colleagues and former students. Their corpus of research into ...

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NEUROIMAGING IN PSYCHIATRY

The international symposium will take place in ...