POLYVALENT pneumococcal polysaccharide vaccine was licensed for use in the United States in late 1977.¹ The licensure was based on the results of randomized clinical trials of the vaccine's protective efficacy in young male African gold miners.^{2 , 3} In ...

GASTROINTESTINAL involvement is common in patients with scleroderma.^{1 2 3} Although abnormalities of esophageal and anorectal function predominate,^{4 5 6 7} approximately one half of those with scleroderma have small-bowel dysfunction.^{8 , 9} In such patients, ...

BECAUSE cardiac contractility is impaired in patients with chronic heart failure, many drugs have been developed to enhance the inotropic state of the failing heart.¹ Some drugs increase the concentration of intracellular sodium, either by stimulating the ...

IN the 1930s Diggs, Pulliam, and King¹ drew attention to the pathologic effects of sickle cell disease on the skeleton, and Grinnan² described the roentgenographic appearance of the bone lesions. There followed many reports in the radiologic and ...

THE detection of monoclonal proteins in the serum of a patient with peripheral neuropathy may lead to the diagnosis of amyloidosis,^{1 2 3} myeloma (multiple^{4 , 5} or osteosclerotic^{6 7 8 9}), Waldenström's macroglobulinemia,^{10 11 12} cryoglobulinemia,^{11 , 12} ...

THE polymyositis and dermatomyositis complex encompasses a heterogeneous group of acquired muscle diseases called inflammatory myopathies because muscle weakness and inflammatory infiltrates within the skeletal muscles are the principal clinical and ...

Presentation of Case

A 68-year-old man was admitted to the hospital because of headache, nausea, vomiting, and abdominal pain.

The patient was in stable health until the day of admission, when he failed to appear for breakfast and lunch at a nursing home ...

IN this issue of the Journal, Shapiro and colleagues present the results of a case–control study of the efficacy of pneumococcal polysaccharide vaccine.¹ In their carefully designed and implemented study, the vaccine had an efficacy of 61 percent (95 ...

MOTILITY disturbances of the gastrointestinal tract will develop in approximately half of all patients with scleroderma,¹ regardless of whether they have the complete CREST syndrome (calcinosis, Raynaud's disease, esophageal involvement, sclerodactyly, ...

MOST reports on clinical trials published in the Journal carry an optimistic message. The new treatment assessed in the trial is usually found to be superior to, or at least as good as, conventional therapy for the condition. In this issue of the Journal, ...

LARGE clinical trials from multiple institutions now involve dozens and sometimes hundreds of people in their conception, design, implementation, analysis, and preparation of reports for publication. Increasingly, we have become concerned about two ...

DEATHS

Bordenca — Morris Joseph Bordenca, M.D., of Waltham, died on October 6 at the age of 71.

Dr. Bordenca graduated from Tufts College Medical School in 1945. He was a member of the American Medical Association.

Borno — Raymond P. Borno, M.D., of ...

To the Editor: Data suggesting that people with AIDS or AIDS-related conditions may have an antibody against a 25-kd platelet protein that is not present in those without this diagnosis were reported by our laboratories (Stricker RB, Abrams DI, Corash L, ...

To the Editor: In their Sounding Board article on problems of the randomized clinical trial (May 30 issue),¹ Hellman and Hellman begin with a dichotomy: a physician must act in the patient's best interest, and a scientist must act to promote knowledge. ...

To the Editor: The International Chronic Granulomatous Disease Cooperative Study Group recently reported (Feb. 21 issue)¹ on the efficacy of interferon gamma in preventing serious infections in patients with chronic granulomatous disease. The clinical ...

To the Editor: Poynard et al. (May 30 issue)* reported the beneficial effect of beta-adrenergic—antagonist drugs in the prevention of first episodes of gastrointestinal bleeding and in the reduction of the mortality rate associated with gastrointestinal ...

To the Editor: We write to bring to your attention a possible discrepancy in the report by the Southern Surgeons Club (April 18 issue).* The paper states that seven bile-duct injuries occurred. All three of the injuries that were not recognized at the ...

To the Editor: Endothelin is a novel endothelium-derived peptide with a potent vasoconstrictor effect.¹ To elucidate the role of vascular endothelial cells after major trauma, we studied concentrations of endothelin-1 and big endothelin in 11 severely ...

To the Editor: Chemical keratitis from air-bag discharge of alkali was reported by Ingraham et al. (May 30 issue).¹ We have seen two cases of a previously unreported but equally worrisome condition, contusion to the eyes of drivers during air-bag ...

In its second edition this authoritative book remains a classic and should be regarded as the gold standard with which all other textbooks on trauma are compared. The editors are internationally recognized experts in the field, as are many of the more ...

The first edition of Surgical Management, published in 1984, was aimed principally at the practicing surgeon. This second edition has been revised extensively, with the intention of providing a book that is "absolutely up-to-date, easy to read and well ...

The Atlas of Abdominal Surgery is designed to illustrate for the practicing surgeon "the most up-to-date, safe and effective" techniques. Diagnostic considerations as well as preoperative and postoperative care are intentionally not included. The ...

This book can accurately be described as providing a basic introduction to laparoscopic surgery of the gallbladder, primarily cholecystectomy, but also Cholecystotomy. It details not only the surgical techniques but also the related instrumentation and ...

Surgical Laparoscopy is one of the first textbooks on laparoscopy for the general surgeon. Because the field of laparoscopic general surgery is new and developments are occurring rapidly, some statements in the book are already outdated.

The book has two ...

Thanks to the efforts of Marvin E. Steinberg, an experienced hip surgeon, his 5 section editors, and 72 authors and coauthors, this textbook is truly comprehensive. The Hip and Its Disorders is divided into six logical sections that overlap only slightly, ...

When originally published in 1973, Otolaryngology was the first modern multivolume textbook in this specialty area. The second edition varied only slightly from the original, but the third edition is a major revision; the number of pages has increased ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits. The Journal does not publish unsolicited ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

CALL FOR ABSTRACTS

Abstracts for papers and posters are now being accepted ...