AS early as 1987, the acquired immunodeficiency syndrome (AIDS) was the ninth leading cause of death in U.S. children from one through four years of age.^{1 , 2} Children with human immunodeficiency virus (HIV) infection may have profound dysfunction in ...

IN a recent double-blind study, the Cooperative Group for the Study of Immunoglobulin in Chronic Lymphocytic Leukemia randomly assigned patients with chronic lymphocytic leukemia who were at high risk for infection to receive intravenous immune globulin ...

OSTEOARTHRITIS is the most common joint disease; as much as 80 percent of the population has radiographic evidence of osteoarthritis by the age of 65.¹ Although only about 60 percent of patients with radiographically detectable osteoarthritis have ...

RECENT outbreaks of acute rheumatic fever^{1 2 3} and b. increases in the frequency of severe streptococcal infections^{4 5 6 7 8} are reminders of the severe morbidity that Streptococcus pyogenes may produce. Many of the S. pyogenes isolates described in ...

THE genome of the hepatitis C virus (HCV), the etiologic agent of post-transfusion non-A, non-B hepatitis, was recently identified, and the products of viral genes were expressed in prokaryotic and eukaryotic systems.¹ Infection with HCV is routinely ...

THE epidemic of human immunodeficiency virus type 1 (HIV-1) infection in areas of the tropics where Plasmodium falciparum is endemic has generated serious concern about potential interactions between the two infections.^{1 , 2} Since the cellular immune ...

WITH the discovery of agammaglobulinemia in 1952,¹ a pressing need emerged for antibody-replacement therapy to prevent serious bacterial infections. Intramuscularly administered immune serum globulin resulted in a remarkable decrease in the incidence of ...

Presentation of Case

A 41-year-old woman was admitted to the hospital because of pain in the right lower abdominal quadrant.

The patient was well until 36 hours earlier, when she experienced the onset of an insidious, throbbing "ache" in the right lower ...

The Physicians' Desk Reference and the package inserts state that intravenous immune globulin is indicated for patients who have primary antibody immunodeficiency or immune thrombocytopenic purpura, both fairly rare disorders. Why, then, will the ...

An estimated 15.8 million adults, or 12.1 percent of the U.S. population 25 to 74 years old, have signs and symptoms of osteoarthritis,¹ making this group of conditions one of the most important public health problems among the musculoskeletal diseases. ...

The report by Gray et al. in this issue of the Journal adds another chapter to the amazing saga of the return of virulence of the group A streptococcus (Streptococcus pyogenes).¹ Recent reports of the resurgence of acute rheumatic fever and the occurrence ...

DEATHS

Biller — Albert L. Biller, M.D., of Worcester, died on May 12. He was 86.

Dr. Biller received his degree from Middlesex University School of Medicine in 1930. He was a 50-year member of the Massachusetts Medical Society.

Decker — Briant LeRay ...

To the Editor: The Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) demonstrates that treatment With "low dose" warfarin reduces strokes and mortality in patients with non-rheumatic atrial fibrillation.¹ This report and the two other ...

To the Editor: Interferon treatment of chronic myelogenous leukemia can lead to hematologic as well as cytogenetic remissions.^{1 2 3 4 5} We report cytogenetic data for 44 patients with chronic myelogenous leukemia who were treated with interferon alfa-2b. ...

To the Editor: Sullivan and colleagues (Sept. 13 issue)¹ reported that patients receiving intravenous polyvalent immune globulin after bone marrow transplantation had a significantly reduced risk of septicemia, local infection, interstitial pneumonia, ...

To the Editor: Streptococcus pneumoniae is a common pathogen in children, in whom it causes a variety of infectious and noninfectious syndromes. One of the less well recognized syndromes is the hemolytic uremic syndrome occurring as a complication of a ...

To the Editor: The current increase in the numbers of cases of measles and congenital rubella has prompted a reevaluation of immunization strategies because of the increasing numbers of adults and children who are susceptible to these potentially ...

To the Editor: A number of factors, such as fatigue, sleep deprivation, and menstruation, may aggravate epileptic seizures. In about 5 percent of patients the seizures are triggered by specific sensory stimuli.¹ A case of photosensitive epilepsy induced ...

To the Editor: Dr. Klumpp indicates in the November 1 issue of the Journal ¹ that he felt forced to abandon a research fellowship because of the payback provisions of the National Research Service Award (NRSA). He says "the contract states that the ...

To the Editor: In my editorial on amyotrophic lateral sclerosis (May 16 issue),* the statement that a lod score of 5 represents odds of 10,000 to 1 in favor of linkage should have said odds of 100,000 to 1.

To the Editor: The rise of street gangs and the increase in urban violence have led to obvious effects on the health status of the inner city through drug abuse, physical violence, broken families, and neglected children, to name a few. It appears that ...

By size the Marine was engulfed by his bed.

Swallowed up behind tubes and machines, The brief experience of his 20 years hidden behind the science necessary to keep him alive.

Memories of the prom, his sister, and piano lessons oozing slowly into the ...

Patient-controlled analgesia (PCA) has achieved acceptance with remarkable rapidity. This book comprises 23 chapters by a variety of authors from several disciplines. And rightly so, since in most clinical settings PCA is the responsibility of a variety ...

Treatment of Chronic Pain: Possibilities, limitations and long-term follow-up Edited by M. Mumenthaler, P.A. Van Zwieten, and J.M. Farcot. 337 pp., illustrated. New York, Harwood, 1990. $95 (cloth); $63 (paper).

Several new books on the diagnosis and ...

I highly recommend this book to orthopedic surgeons, residents in training, school physicians, and other practitioners involved in the training and treatment of athletes at all levels of ability. It covers the upper extremity comprehensively and is well ...

The first edition of this textbook, entitled Complications of Urologic Surgery, has been a very useful reference for the practicing urologist. The surgical management of urologic diseases has changed markedly since its publication in 1976. Therefore, the ...

This second edition provides readers with a comprehensive textbook that considers all aspects of enteral nutrition from Abbott-Rawson tubes to zinc supplementation. In between are chapters on the requirements for and surgical and endoscopic approaches to ...

Biomedical Science

Anti-Idiotypic Vaccines. (Progress in Vaccinology. Vol. 3.) Edited by P.-A. Cazenave. 139 pp., illustrated. New York, Springer-Verlag, 1991. $79.

Blueprint for a Cell: The nature and origin of life. By Christian de Duve. 275 pp., ...

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OHIO STATE UNIVERSITY HOSPITALS

The following conferences will be held in ...