ALTHOUGH non-A, non-B hepatitis was first recognized in 1974,^{1 , 2} identification of the responsible etiologic agent or agents proved difficult. Prospective studies conducted in the United States during the 1970s demonstrated that hepatitis developed as a ...

THE ability to cure acute lymphoblastic leukemia (ALL) occurring in childhood is regarded as one of the landmark developments of the past 30 years in cancer therapy.^{1 , 2} Current therapy can be expected to produce remission in over 95 percent of children ...

THE proportion of isolates of Neisseria gonorrhoeae in the United States that had absolute or relative resistance to the penicillins or tetracyclines rose greatly in the 1980s, especially in the second half of the decade.¹ By 1989, ≥5 percent of cases of ...

METASTATIC breast cancer is an incurable disease. Although endocrine therapy, chemotherapy, or both may produce an objective response, almost all patients subsequently have progressive disease and die of their illness. Objective responses to combination ...

BONE marrow transplantation is the only therapy that has been reported to cure patients with sickle cell disease.^{1 2 3} However, when performed for currently accepted indications, this procedure is associated with a 10 to 50 percent risk of mortality and ...

PHYSICIANS often regard Gaucher's disease as a rare, esoteric, untreatable disorder. Fortunately, the more severe forms of the disease are indeed quite uncommon, but milder forms of Gaucher's disease are encountered frequently, particularly in the Jewish ...

Presentation of Case

An 84-year-old man was admitted to the hospital because of a mass in the left leg.

The patient was in stable health until three years earlier, when he became aware of a mass in the left popliteal space. A physician aspirated the mass ...

DURING the 20th century, our efforts to control sexually transmitted diseases (STDs) have been guided by both the magnitude of the problem and the availability of diagnostic and therapeutic measures. We began the 1900s focusing on one dominant STD —...

WITHIN the young discipline of medical oncology, the systemic therapy of metastatic breast cancer has a long history. Bilateral oophorectomy, which was noted in the 19th century to cause the regression of advanced disease, was the first effective ...

THE Journal has long had a policy, known as the Ingelfinger Rule, of considering a manuscript for publication only if its substance has not been submitted or reported elsewhere. This policy was promulgated in 1969 by the editor, Franz J. Ingelfinger,¹ to ...

PREVENTION of premature births is the most important challenge in obstetrics. Recently a device for monitoring uterine activity at home (the Genesis Home Uterine Activity Monitor [HUAM] system, Tokos Medical Group), coupled with daily contact between ...

SACHS et al., in discussing the Food and Drug Administration's approval of marketing of the Genesis Home Uterine Activity Monitor (HUAM), raise issues that require clarification.

The authors contend that because the Genesis HUAM has not been shown to ...

SACHS et al. highlight the important and difficult challenge of preventing preterm births. The evaluation of HUAM, however, was made without access to all the data and misrepresents the results of the Physiologic Diagnostic Service study¹ that formed the ...

To the Editor: Wiersma and coworkers (March 21 issue)¹ found that expression of myeloid antigens (CD14 [My4], CD13 [My7], and CD33 [My9]) was an independent predictor of a poor outcome among 236 children with acute lymphoblastic leukemia (ALL) treated ...

To the Editor: Conneally has presented an informative discussion of the implications of the detection of markers for a major gene (May 16 issue).¹ The immediate stimulus was the report by Siddique et al. in the same issue of four DNA markers on the long ...

To the Editor: In the recent review of rhabdomyolysis, Odeh (May 16 issue)¹ stated that a "protective effect of mannitol on the kidneys in rhabdomyolysis is well recognized." The study by Eneas and colleagues² cited by Odeh was a retrospective review of ...

To the Editor: I am writing in regard to a statement in Case 22–1991 (May 30 issue).¹ Dr. Podolsky asserts that "thrombosis as a reflection of an underlying coagulopathy, including antithrombin III deficiency,... deficiency of protein S... can be ...

To the Editor: Hillman et al. concentrate on the roles of investigators, their institutions, and manufacturers in their discussion of bias in cost-effectiveness research (May 9 issue).¹ We wish to extend this discussion by describing how one regulatory ...

To the Editor: A recent experience with a motorized water ski may provide physicians with a reminder of the four physical factors involved in the formation of pressure sores.

A 36-year-old physician, without a history of pressure sores, was a passenger ...

Today, when social planners and medical economists are ascendant and "bottom line" thinking is rampant, this compact history of medicine gone awry is a welcome and needed reminder that our society and our profession must choose our goals carefully because ...

Medical decisions today are apt to involve many people besides the physician and the patient: members of review boards and ethics committees, lawyers, bioethicists, regulators, and representatives of the courts. Before the mid-1960s, however, physicians' ...

This book is a valuable contribution to the history of medicine and to literary history. It is delightfully written, with scholarly depth, and the author has an excellent sense of humor and a genuine interest both in the history of medicine and in ...

"He taught us how to find antibiotics." With those words Howard Florey summed up René Dubos' monumental contribution to the fledgling field of antibiotics research. Focusing especially on the discovery of gramicidin in 1940, this collection of essays ...

There is a small, well-worn book in my library entitled Manual of Tropical Medicine, written by Thomas T. Mackie, George W. Hunter, and C. Brooke Worth. It was published in 1945 by Saunders under the auspices of the National Research Council. My copy ...

The publication of Fluid and Electrolytes enlarges the list of textbooks that set forth the basic principles of water and electrolyte metabolism and provide an approach to the pathophysiology and treatment of electrolyte disturbances. This textbook, like ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits. The Journal does not publish unsolicited ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

CARDIOPULMONARY URGENCIES AND EMERGENCIES

The 7th international symposium ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...