PATIENTS who have a transient ischemic attack or nondisabling ischemic stroke have an annual risk of death from all vascular causes, nonfatal stroke, or nonfatal myocardial infarction of 7 to 12 percent.^{1 2 3 4} An overview by the Antiplatelet Trialists' ...

MULTIPLE myeloma is a fatal disorder with a median survival of about 36 months after conventional chemotherapy.^{1 2 3} Even so, more than 50 percent of patients with multiple myeloma respond to first-line therapy, and some patients may even have a complete ...

ALTHOUGH advances in antimicrobial therapy have markedly reduced the mortality associated with infection after chemotherapy-induced neutropenia, fungal infections, especially candidiasis, remain a leading cause of morbidity and mortality during ...

PANCREAS transplantation offers a means of normalizing plasma glucose concentrations in patients with insulin-dependent diabetes mellitus (IDDM) and therefore the possibility of delaying or preventing the long-term complications of the disease. However, ...

HIGH-ALTITUDE pulmonary edema is a form of noncardiogenic pulmonary edema that develops within the first days after rapid ascent to altitudes above 2500 to 3000 m.^{1 , 2} The frequency of high-altitude pulmonary edema depends on the elevation, gain in ...

STORIES have been told about physicians who treat their own family members, but to the best of our knowledge, this practice has not been studied. Family members may benefit; they may avoid the inconvenience and expense of an office visit and gain an ...

Presentation of Case

First admission. A 17-year-old girl was admitted to the hospital because of recurrent abdominal pain and a mass in the right lower abdominal quadrant.

The patient was well until three months earlier, when she experienced the onset of ...

I have no other motives for publishing this valuable specific than that it may have a fair and full trial in all its variety of circumstances and situations, and that the world may reap the benefits accruing from it.

In 1763 the Reverend Edward Stone of ...

THERE has been little progress in the treatment of multiple myeloma since the introduction of the melphalan—prednisone regimen about 25 years ago (for review, see Barlogie et al.¹). The lack of benefit from the addition of alkylating agents and ...

ON August 10, 1894, Pietro Ramella, a young Italian soldier taking part in physiological experiments, ascended rapidly to the Capanna Regina Margherita hut on Monte Rosa (4559 m), an Alpine peak bordering Italy and Switzerland. Within a day he had severe ...

PROPONENTS of Initiative 119 in the state of Washington have gathered more than the 150,000 signatures required to put the initiative on the ballot in November 1991.¹ The measure would amend the state's natural-death act to permit "physician aid in dying,"...

To the Editor: Although the benefits of zidovudine therapy with regard to the clinical status of patients with the acquired immunodeficiency syndrome (AIDS) are well documented,¹ the effect of this therapy on survival is as yet unknown. In their ...

To the Editor: Jacobs et al. report cases of Pneumocystis carinii pneumonia occurring over a 10-week period in five adults without predisposing illnesses (Jan. 24 issue)¹; four of the cases occurred over a 4-week period. In a few of the patients, the ...

To the Editor: Fluconazole, a bis-triazole antifungal agent, has excellent activity in vitro and in vivo against various candida species and is effective in the treatment of oropharyngeal candidiasis in patients with cancer and in patients infected with ...

To the Editor: Ondansetron, a serotonin-receptor antagonist, was approved by the Food and Drug Administration in January 1991 for use in the prevention of nausea and vomiting associated with chemotherapy. Most of the premarketing studies of ondansetron ...

To the Editor: A 58-year-old woman was hospitalized with a two-month history of pain in the right hypochondrium. Ultrasonography demonstrated a contracted gallbladder containing a stone. Endoscopic retrograde cholangiography showed no stones in the ...

To the Editor: Woolhandler and Himmelstein (May 2 issue)* suggest that an excessive and inefficient administrative structure is the villain behind this nation's health care crisis. They arrive at this conclusion by comparing health care expenses in ...

Heart disease in young patients often creates anxiety in physicians during their training and later in practice. Part of this fear is based on the mystique of the heart, part is due to the possibility of a life-threatening situation, and part is related ...

Intrapartum electronic monitoring of the fetal heart rate was introduced with great enthusiasm in the early 1970s. It was hoped that with the ability to recognize intrapartum fetal asphyxia and to intervene in a timely fashion, the incidence of neurologic ...

For many of us trained in a cardiology fellowship oriented toward adult patients, Joseph Perloff's classic textbook Clinical Recognition of Congenital Heart Disease (3rd ed. Philadelphia: W.B. Saunders, 1987) was the framework around which we structured ...

According to the preface, this book is directed toward noncardiologists and is intended to provide an overview of current clinical cardiology. An accessible source of information for physicians not involved in the practice of cardiology is desperately ...

This book is intended to be a comprehensive outline of radiographic findings useful in differential diagnosis. Its illustrations should be particularly useful to physicians with some experience in radiology who wish to strengthen their diagnostic skills. ...

Radiology of Chest Diseases is an ambitious attempt to cover the field of thoracic radiology in 293 pages. Because of its size, it cannot cover individual subjects in great depth or detail.

The book is divided into three sections: the first is devoted to ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits. The Journal does not publish unsolicited ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

CRITICAL CARE MEDICINE REVIEW

The program, a "refresher course for internal ...

Measurement of Prostate-Specific Antigen in Serum as a Screening Test for Prostate Cancer (April 25,1991;324:1156–61). On page 1156, in the right-hand column, the paragraph under the subheading "PSA Assay," the second sentence should have read, "We used ...

A Clinical Trial of Beta Carotene to Prevent Basal-Cell and Squamous-Cell Cancers of the Skin (September 20, 1990;323:789–95). On page 792, the first line of text in the left-hand column, and on page 793, the second heading in Table 5, state that the ...